Effects of Alendronate on Rate of Distraction in Rabbit Mandibles

Tekin, Umut; Tüz, Hakan H.; Önder, M. Ercüment; Özkaynak, Özkan; Korkusuz, Petek

doi:10.1016/j.joms.2008.06.023

Cited by 25 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results showed that fast rates of distraction diminish the quality of new bone formation, and the distraction gap may be adversely affected. At slow rates, there is a risk of premature union and the lengthening aim is not successful 14,24 . It has been asserted that the optimal rate of distraction is between 0.7 and 1.3 mm/day, twice daily lengthening, for cell proliferation and histological characteristics 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, biphosphonates appear to have the potential to stimulate osteoblast proliferation and differentiation, which cause enhanced bone formation 11,27 . Alendronate also exhibits positive effects on osteoblast maturation and bone-forming activities 24 .…”

Section: Discussionmentioning

confidence: 99%

“…Distraction osteogenesis (DO), which is used widely to treat oral and maxillofacial deformities or deficiencies, is a biologic procedure that produces new bone formation via gradually separated bone segments, using an external lengthener 4,6,24 . The main advantage of this technique is that bone formation occurs in parallel with elongation of the surrounding soft tissue envelope 14 .…”

mentioning

confidence: 99%

“…For that reason, in the present study, numerous approaches were researched to accelerate the maturation of the regenerate bone including growth factors 15 , hormones 12,23 , calcium sulphate 2 , and electronic 10 and ultrasonic 22 stimulation. In recent studies, bisphosphonates 8,20,24 were indicated to be efficient in hastening bone regeneration.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Comparison of local and systemic alendronate on distraction osteogenesis

Küçük

Kara

et al. 2011

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Comparison of local and systemic alendronate on distraction osteogenesis

Küçük

Kara

et al. 2011

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…At least one study have investigated the effect of various sex hormones on bladder urodynamics (Celayir & Ilce 2005). A further one examined the effects of administration of biphosphonates on bone healing (Tekin et al 2008). The histomorphology of the oviduct has also been the subject of study (Ozen et al 2010) as has the anatomy of the carotid body (Eken et al 2008).…”

Section: Use As An Animal Modelmentioning

confidence: 99%

The domestic livestock resources of Turkey: Notes on rabbits and a review of the literature

Wilson

Yılmaz

2013

Arch. Anim. Breed.

View full text Add to dashboard Cite

The Turkish wild rabbit is known from ancient times. As a minor component of Turkey's array of livestock and poultry there is no official information on numbers or production. The iconic Angora is the only native breed. Imported breeds include New Zealand White, California, Chinchilla, Line V and French Angora. The Angora is a registered breed and is being conserved ex situ in vivo. Official data give Angora weight as 3.5-4.0 kg in males and 4.0-4.5 kg in females, fibre production as 700-800 g from bucks and 1 000 g from does from four clips per year, first breeding age as 6 months, litter size 1-6 kits and production of four litters per year. Production research is limited but generally shows lower fibre output than official data. A comparative study with California and Line V rabbits showed the latter was heavier at birth and grew faster to 10 weeks. The rabbit has been used as an animal model in several studies. There is little information on meat and fibre marketing as there is on international trade but there have been sporadic imports of meat. Pathologies include coccidiosis, mange and myiasis. Constraints include lack of producer knowledge, poor quality feed, inadequate housing and lack of breeding stock. Opportunities lie in public and private support, genetic improvement for fibre for product diversification and increased incomes, improved marketing and niche markets for low cholesterol and low fat meat.

show abstract