Effects of alcohol on TMS-evoked N100 responses

Kähkönen, Seppo; Wilenius, Juha

doi:10.1016/j.jneumeth.2007.06.030

Cited by 53 publications

(41 citation statements)

References 24 publications

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“…A reduction of the N100 amplitude has also been observed when the delivery of a TMS pulse over the M1 hand area is shortly (25 ms) preceded by a somatosensory stimulus applied to the contralateral hand (Bikmullina et al, 2009), in accord to short-latency afferent inhibition in MEP recordings (Tokimura et al, 2000). The N100 was almost abolished when the TMS coil is rotated by 90°relative to the optimal orientation (Bonato et al, 2006) and after alcohol ingestion (Kähkönen and Wilenius, 2007). Furthermore, the N100 amplitude was significantly increased after 1 Hz rTMS applied over M1 (Casula et al, 2014), and significantly correlated with the duration of the cortical silent period (Farzan et al, 2013), which is thought to reflect cortical inhibitory processes (see Section 2.2.3.…”

Section: Late Components Of Motor Cortex Tepsmentioning

confidence: 80%

TMS and drugs revisited 2014

Ziemann

Reis

Schwenkreis

et al. 2015

Clinical Neurophysiology

558

583

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Section: Late Components Of Motor Cortex Tepsmentioning

confidence: 80%

TMS and drugs revisited 2014

Ziemann

Reis

Schwenkreis

et al. 2015

Clinical Neurophysiology

558

583

View full text Add to dashboard Cite

“…N100, which is the dominant r nTMS-EEG Reproducibility r r 1393 r peak in TMS-evoked EEG, is very sensitive to small changes in cortical excitability. It may represent cortical inhibition elicited by TMS [Bender et al, 2005;Kähkö nen and Wilenius, 2007;Kičić et al, 2008;Nikulin et al, 2003]. The N100-P180 complex may contain an auditory response to the TMS coil click; part of this response is due to boneconducted sound [Nikouline et al, 1999].…”

Section: Reproducibility Of Eeg Deflectionsmentioning

confidence: 99%

Reproducibility of TMS—Evoked EEG responses

Lioumis

Kičić²,

Savolainen

et al. 2008

Human Brain Mapping

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264

239

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Navigated transcranial magnetic stimulation combined with electroencephalography (nTMS-EEG), allows noninvasive studies of cortical excitability and connectivity in humans. We investigated the reproducibility of nTMS-EEG in seven healthy subjects by repeating left motor and prefrontal cortical stimulation with a 1-week interval. TMS was applied at three intensities: 90, 100, and 110% of subjects' motor threshold (MT). The TMS-compatible neuronavigation system guaranteed precise repositioning of the stimulation coil. The responses were recorded by a 60-channel whole head TMS-compatible EEG amplifier. A high overall reproducibility (r > 0.80) was evident in nTMS-EEG responses over both hemispheres for both motor and prefrontal cortical stimulation. The results suggest that nTMS-EEG is a reliable tool for studies investigating cortical excitability changes in the test-retest designs.

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“…The temporal evolution of TEPs over the scalp is thought to reflect the spread of activation from the stimulation site to other cortical areas through corticocortical fibers or subcortical structures. It provides information on the reactivity and connectivity of different cerebral cortex areas (Massimini et al, 2007;Paus et al, 2001;Taylor et al, 2008) and on how this reactivity might be modulated by extrinsic factors such as sleep deprivation or alcohol intake (Del Felice et al, 2011;Kähkönen and Wilenius, 2007). In the early stages of brain damage (e.g., ischemic lesions), this "perturbational approach" may be a powerful tool for exploring how affected brain areas might causally interact and how intra-cortical connections might be modu-lated.…”

Section: Introductionmentioning

confidence: 99%

TMS-evoked N100 responses as a prognostic factor in acute stroke

Manganotti

Acler²,

Masiero

et al. 2015

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SummaryRehabilitation programs, to be efficiently tailored, need clear prognostic markers. In acute stroke, neurophysiological measures, such as motor evoked potentials (MEPs), have been proposed, although with discordant results. The aim of this study was to identify a reliable neurophysiological measure of recovery in acute poststroke individuals by combining MEPs and the N100 component of transcranial magnetic stimulationevoked potentials (TEPs). Nine acute post-stroke subjects were included. Clinical evaluation performed in the first week after the event included administration of the European Stroke Scale and Barthel Index and recording of MEPs and TEPs; administration of the clinical scales was repeated after one and three months. The presence/absence of MEPs and TEPs showed correlations with motor outcome. Individuals with a poorer outcome showed absence of both MEPs and TEPs; absence of MEPs alone was related to a partial recovery. Given the results of this exploratory study, further investigation is needed to define the accuracy of combined use of MEPs and TEPs as an approach for predicting motor recovery after acute stroke.

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Effects of alcohol on TMS-evoked N100 responses

Cited by 53 publications

References 24 publications

TMS and drugs revisited 2014

TMS and drugs revisited 2014

Reproducibility of TMS—Evoked EEG responses

TMS-evoked N100 responses as a prognostic factor in acute stroke

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