Effects of alcohol on thermoregulation during mild heat exposure in humans

Yoda, Teruhiko; Crawshaw, Larry I.; Nakamura, Mayumi; Saito, Kumiko; Konishi, Aki; Nagashima, Kei; Uchida, Sunao; Kanosue, Kazuyuki

doi:10.1016/j.alcohol.2005.09.002

Cited by 40 publications

(23 citation statements)

References 25 publications

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“…Some well-known substances, such as alcohol [8] and anesthetics [5], may affect the central nervous system and induce anapyrexia. Besides them, some toxic chemicals examined appear to cause anapyrexia in animal studies [9][10][11][12][13].…”

Section: Known Exogenous and Endogenous Cryogensmentioning

confidence: 99%

Possible Human Endogenous Cryogens

Shido¹,

Sugimoto²

2011

CPPS

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Anapyrexia, which is a regulated fall in core temperature, is beneficial for animals and humans when the oxygen supply is limited, e.g., hypoxic, ischemic, or histotoxic hypoxia, since at low body temperature the tissues require less oxygen due to Q(10). Besides hypoxia, anapyrexia can be induced various exogenous and endogenous substances, named cryogens. However, there are only a few reports investigating endogenous cryogens in mammals. We have experienced one patient who suffered from severe hypothermia. The patient seemed to be excessively producing endogenous peptidergic cryogenic substances the molecular weight of which may be greater than 30 kDa. In animal studies, the patient's cryogen appeared to affect metabolic functions, including thermogenic threshold temperatures, and then to produce hypothermia. Since endogenous cryogenic substances may be regarded as useful tool in human activities, e.g., during brain hypothermia therapy or staying in a space station or spaceship, further studies may be needed to identify human endogenous cryogens.

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Section: Known Exogenous and Endogenous Cryogensmentioning

confidence: 99%

Possible Human Endogenous Cryogens

Shido¹,

Sugimoto²

2011

CPPS

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“…Only a few small studies have investigated signs of anxiety and depression in persons with hyperhidrosis, however, no such links have been found . Alcohol affects thermoregulation in the body and sweating through pathways that are yet not completely understood . Alcohol and its potential role in primary hyperhidrosis has not formerly been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Alcohol affects thermoregulation in the body and sweating through pathways that are yet not completely understood. 17,18 Alcohol and its potential role in primary hyperhidrosis has not formerly been investigated.…”

Section: Introductionmentioning

confidence: 99%

Primary hyperhidrosis: Implications on symptoms, daily life, health and alcohol consumption when treated with botulinum toxin

Shayesteh

Boman

Janlert

et al. 2016

The Journal of Dermatology

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Primary hyperhidrosis affects approximately 3% of the population and reduces quality of life in affected persons. Few studies have investigated the symptoms of anxiety, depression and hazardous alcohol consumption among those with hyperhidrosis and the effect of treatment with botulinum toxin. The first aim of this study was to investigate the effect of primary hyperhidrosis on mental and physical health, and alcohol consumption. Our second aim was to study whether and how treatment with botulinum toxin changed these effects. One hundred and fourteen patients answered questionnaires regarding hyperhidrosis and symptoms, including hyperhidrosis disease severity scale (HDSS), visual analog scale (VAS) 10-point scale for hyperhidrosis symptoms, hospital anxiety and depression scale (HADS), alcohol use disorder identification test (AUDIT) and short-form health survey (SF-36) before treatment with botulinum toxin and 2 weeks after. The age of onset of hyperhidrosis was on average 13.4 years and 48% described heredity for hyperhidrosis. Significant improvements were noted in patients with axillary and palmar hyperhidrosis regarding mean HDSS, VAS 10-point scale, HADS, SF-36 and sweat-related health problems 2 weeks after treatment with botulinum toxin. Changes in mean AUDIT for all participants were not significant. Primary hyperhidrosis mainly impairs mental rather than physical aspects of life and also interferes with specific daily activities of the affected individuals. Despite this, our patients did not show signs of anxiety, depression or hazardous alcohol consumption. Treatment with botulinum toxin reduced sweat-related problems and led to significant improvements in HDSS, VAS, HADS and SF-36 in our patients.

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“…In warm environments, moderate doses of alcohol seem to have variable effects on thermoregulatory responses during exercise: varying patterns of thermal response are typically seen, with no consistent effect on the thermoregulatory response, suggesting that the capacity to regulate core temperature is not fundamentally altered by alcohol ingestion (Desruelle et al, 1996). With mild thermal stress in the absence of exercise, there may be a slight increase in skin temperature and in the sensation of warmth after alcohol ingestion, and this is followed by a fall in core temperature (Yoda et al, 2005). Small doses of ethanol, given to human volunteers at rest in the absence of a thermal stress, have very little effect on body temperature but large doses administered before exercise at low ambient temperatures result in increased peripheral vasodilatation and can precipitate a marked fall in core temperature.…”

Section: Hydration and Thermoregulatory Functionmentioning

confidence: 99%