Effects of alcohol on folate metabolism: implications for carcinogenesis

Mason, Joel B.; Choi, Sang‐Woon

doi:10.1016/j.alcohol.2005.03.012

Cited by 168 publications

(142 citation statements)

References 42 publications

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“…Alcohol consumption is also associated with altered levels of methyltransferase activity and DNA methylation (71,109). In both animal and in vitro studies, alcohol has been shown to impede the bioavailability of dietary folate and inhibit folate-dependent biochemical reactions (114,115).…”

Section: Other Lifestyle Factorsmentioning

confidence: 99%

Prospects for Epigenetic Epidemiology

Foley¹,

Craig²,

Morley³

et al. 2008

American Journal of Epidemiology

218

162

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Section: Other Lifestyle Factorsmentioning

confidence: 99%

Prospects for Epigenetic Epidemiology

Foley¹,

Craig²,

Morley³

et al. 2008

American Journal of Epidemiology

218

162

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“…consumidores crônicos de álcool 39,40 . As ingestões baixas a moderadas apresentadas pela amostra do presente estudo podem explicar parcialmente porque não foi encontrado prejuízo do estado nutricional referente às vitaminas entre as participantes que referiram consumo habitual de bebida alcoólica.…”

Section: Discussionunclassified

Preditores sócio-demográficos, de estilo de vida e gineco-obstétricos das concentrações séricas ou plasmáticas de homocisteína, ácido fólico e vitaminas B12 e B6 em mulheres de baixa renda de São Paulo, Brasil

et al. 2008

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O presente estudo investigou fatores sócio-demográficos, de estilo de vida e gineco-obstétricos associados às concentrações séricas ou plasmáticas de homocisteína, ácido fólico, vitaminas B12 e B6 em mulheres de baixa renda de São Paulo, Brasil. Concentrações séricas de ácido fólico e vitamina B12 foram analisadas por fluoroimunoensaio; concentrações plasmáticas de homocisteína e vitamina B6, por cromatografia líquida de alta performance em fase reversa. Variáveis independentes foram inicialmente selecionadas segundo pressupostos teóricos, correlação de Pearson ou teste Kruskal-Wallis (p < 0,20). Concentrações alteradas segundo pontos de corte para homocisteína, ácido fólico, vitaminas B12 e B6 foram observadas em 20%, 6%, 11% e 67% das participantes, respectivamente. Idade foi positivamente correlacionada à vitamina B6 e homocisteína plasmáticas (p < 0,001). Índice de massa corporal foi positivamente correlacionado à vitamina B6 plasmática (p < 0,001). Modelos de regressão linear múltiplos explicaram 10,2%, 5,8%, 14,4% e 9,4% das concentrações de ácido fólico, vitamina B12, vitamina B6 e homocisteína, respectivamente. No presente estudo, variáveis sócio-demográficas, de estilo de vida e gineco-obstétricas apresentaram contribuição importante na variação das concentrações dos indicadores bioquímicos avaliados.

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“…It is well known that a strict interaction exists between host and environmental factor and MTHFR C677T SNP. Alcohol may interact with folate metabolism in several ways, i.e., reducing folate absorption, increasing folate excretion, and inhibiting methionine synthase (Mason and Choi, 2005). Accordingly, alcohol drinkers carrying the MTHFR TT genotype have about a fivefold increased risk of gastric cancer compared with drinkers carrying the wild homozygous variant (Graziano et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

MTHFR C677T Polymorphism and Risk of HCC in Patients With Liver Cirrhosis: Role of Male Gender and Alcohol Consumption

Fabris

Toniutto

Falleti

et al. 2008

Alcoholism Clin & Exp Res

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Background: A single nucleotide polymorphism (SNP) C677T in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified. The TT or CT genotypes show a marked reduction of the enzyme activity; this causes higher homocysteine levels and alterations of folate metabolism. Folate metabolism is essential for DNA synthesis and methylation, crucial steps in carcinogenesis. In this paper, we investigated whether the MTHFR C677T SNP could influence the occurrence of hepatocellular carcinoma (HCC) in a cohort of patients transplanted for end stage liver disease of different etiologies.Methods: Two hundred and twelve consecutive patients who underwent liver transplantation for end stage liver disease due to hepatitis B or C, alcoholic liver disease, and other causes were studied. Two hundred and thirty-six blood donors served as controls. Focal hepatic lesions were searched in the sectioned explanted livers. The presence of the MTHFR C677T SNP was determined via polymerase chain reaction amplification.Results: Among the 65 patients with HCC, 22 had the CC genotype, 30 the CT, and 13 the TT genotype. Only in patients with alcoholic liver disease was a significant association detected between the TT genotype and the presence of liver cancer (6 ⁄ 17 vs. 5 ⁄ 46, p < 0.05). At stepwise logistic regression analysis the independent selected predictors of HCC were found: age at transplantation >55 years (p < 0.001) and the association among male gender, alcoholic liver disease, and MTHFR TT genotype (p = 0.002).Conclusions: The present study suggests that male TT carriers with alcoholic cirrhosis bear an increased risk of developing HCC.

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Effects of alcohol on folate metabolism: implications for carcinogenesis

Cited by 168 publications

References 42 publications

Prospects for Epigenetic Epidemiology

Prospects for Epigenetic Epidemiology

Preditores sócio-demográficos, de estilo de vida e gineco-obstétricos das concentrações séricas ou plasmáticas de homocisteína, ácido fólico e vitaminas B12 e B6 em mulheres de baixa renda de São Paulo, Brasil

MTHFR C677T Polymorphism and Risk of HCC in Patients With Liver Cirrhosis: Role of Male Gender and Alcohol Consumption

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