Effects of alcohol ingestion on growth hormone levels: Their relation to 11-hydroxycorticoid levels and serum FFA

Effects of prolonged ethanol administration on the hepatic estrogen receptor in the rat

“…Alcoholics with gynecomastia and cirrhosis have elevated basal prolactin levels in blood [20], and ethanol administration to human volunteers has been reported to cause an elevation of growth hormone levels. [21 ]. Acute ethanol administration causes an increase in blood glucocorticoids, and chronic administration might attenuate this response and change the diurnal rhythm of the glucocorticoids [22].…”

The Metabolic Response to Exercise in Chronic Alcoholics

“…This suggests that acute intake of alcohol stimulates adrenocorticotrophic hormone (ACTH) release. Further evidence for an effect of alcohol on the pituitary comes from the observation that a single oral dose of alcohol (15 ml.kg body wt) can lead to increased secretion of HGH [Bellet, et al, 1971]. In some chronic alcoholics, however, Merry and Marks [1969] reported that plasma cortisol concentrations were paradoxically depressed after alcohol administration.…”

“…Alcoholics had lower levels of growth hormone during exercise compared with the controls suggesting that chronic alcohol consumption has a depressor effect on pathways regulating the release of growth hormone.Moderate exercise produces increased levels of human growth hormone in the blood [Hunter, Fonseka and Passmore, 1965a] and the changes in certain metabolites with exercise give an indication of carbohydrate and fat metabolism. Acute ingestion of ethanol can also lead to increased secretion of human growth hormone [Bellet, Yoshmine, Decastro, Roman, Parma and Sandberg, 1971] and affects carbohydrate metabolism [Hawkins and Kalant, 1972]. Patients with a history of chronically high alcohol intake have a greater decrease in muscle glycogen during exercise than normal subjects [Suominen, Forsberg, Heikkinen and Osterback, 1974].…”

Effect of different times of administration of a single ethanol dose on insulin action, insulin secretion and redox state

“…Ethanol (EtOH) can affect glucose metabolism in several ways. It alters the redox state[1], fatty acid[2] and amino acid metabolism[3], opposes insulin‐mediated glucose uptake[4–6] and affects insulin[7], glucagon[8] growth hormone (GH)[9] and catecholamine secretion[10]. Moreover, EtOH disrupts the physiological response of insulin secretion to glucose, particularly through the action of its metabolites, acetaldehyde and acetate[8, 11].…”