Effects of albendazole treatment on neurocysticercosis: a randomised controlled trial

Carpio, Arturo; Kelvin, Elizabeth A.; Bagiella, Emilia; Leslie, Denise; Leon, Pietro; Andrews, Howard; Hauser, W. Allen

doi:10.1136/jnnp.2008.144899

Cited by 139 publications

(143 citation statements)

References 27 publications

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“…Some of them were included in clinical trials to evaluate efficacy of anthelminthic treatment in individuals with active NCC 27. No individuals included in this phase had been included in phase 1.…”

Section: Methodsmentioning

confidence: 99%

New diagnostic criteria for neurocysticercosis: Reliability and validity

Carpio

Fleury

Romo

et al. 2016

Annals of Neurology

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ObjectiveThe diagnosis of neurocysticercosis (NCC) remains problematic because of the heterogeneity of its clinical, immunological, and imaging characteristics. Our aim was to develop and assess a new set of diagnostic criteria for NCC, which might allow for the accurate detection of, and differentiation between, parenchymal and extraparenchymal disease.MethodsA group of Latin American NCC experts developed by consensus a new set of diagnostic criteria for NCC. A multicenter, retrospective study was then conducted to validate it. The reference standard for diagnosis of active NCC was the disappearance or reduction of cysts after anthelmintic treatment. In total, three pairs of independent neurologists blinded to the diagnosis evaluated 93 cases (with NCC) and 93 controls (without NCC) using the new diagnostic criteria. Mixed‐effects logistic regression models were used to estimate sensitivity and specificity.ResultsInter‐rater reliability (kappa) of diagnosis among evaluators was 0.60. For diagnosis of NCC versus no NCC, the new criteria had a sensitivity of 93.2% and specificity of 81.4%. For parenchymal NCC, the new criteria had a sensitivity of 89.8% and specificity of 80.7% and for extraparenchymal NCC, the new criteria had a sensitivity of 65.9% and specificity of 94.9%.InterpretationThese criteria have acceptable reliability and validity and could be a new tool for clinicians and researchers. An advantage of the new criteria is that they consider parasite location (ie, parenchymal or extraparenchymal), which is an important factor determining the clinical, immunological, and radiological presentation of the disease, and importantly, its treatment and prognosis. Ann Neurol 2016;80:434–442

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Section: Methodsmentioning

confidence: 99%

New diagnostic criteria for neurocysticercosis: Reliability and validity

Carpio

Fleury

Romo

et al. 2016

Annals of Neurology

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“…12 However, ABZ only kills approximately 70% of cysts and clears all living parasites in only 30% to 40% of treated patients after a course of treatment. 7,13,14 On the basis of previous successful studies of pig treatment with oxfendazole (OFZ), this controlled study was developed to explore the efficacy of combined therapy (ABZ plus PZQ) versus ABZ or PZQ alone. Nitazoxanide (NZX), a broad-spectrum drug with activity against a wide variety of intestinal parasites in animals and humans 15,16 was also evaluated.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Diverse Antiparasitic Treatments for Cysticercosis in the Pig Model

González

Bustos

Jimenez

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Taenia solium cysticercosis infects pigs and humans. Because antiparasitic treatment for human cysticercosis has sub-optimal efficacy, alternative regimes are needed. Seven antiparasitic regimens were tested in 42 naturally infected pigs with cysticercosis, and compared with prednisone alone (n = 6) or no treatment (n = 6). The numbers of viable cysts in muscles and in the brain were examined after necropsy and were significantly decreased in pigs receiving combined albendazole plus praziquantel, albendazole alone, or oxfendazole. Pigs receiving praziquantel alone and nitazoxanide had numerous surviving cysts. Control (untreated) pigs and prednisone-treated pigs had many more viable cysts, suggesting no effect. Combined albendazole plus praziquantel, and oxfendazole, showed a strong cysticidal effect and provide suitable alternative treatments to be further explored for their use for treatment of human neurocysticercosis.

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“…In two studies [25,26] which provided definitions of clinical manifestations, depression was reported about 53% and 15%, respectively. Differences on gender have also been identified.…”

Section: Parenchymal Neurocysticercosismentioning

confidence: 99%

Clinical Diagnoses of Neurocysticercosis

Carpio¹

2013

Novel Aspects on Cysticercosis and Neurocysticercosis

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Effects of albendazole treatment on neurocysticercosis: a randomised controlled trial

Cited by 139 publications

References 27 publications

New diagnostic criteria for neurocysticercosis: Reliability and validity

New diagnostic criteria for neurocysticercosis: Reliability and validity

Efficacy of Diverse Antiparasitic Treatments for Cysticercosis in the Pig Model

Clinical Diagnoses of Neurocysticercosis

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