Effects of Akkermansia muciniphila and Faecalibacterium prausnitzii on serotonin transporter expression in intestinal epithelial cells

Yaghoubfar, Rezvan; Behrouzi, Ava; Fateh, Abolfazl; Nojoumi, Seyed Ali; Vaziri, Farzam; Khatami, Shohreh; Siadat, Seyed Davar

doi:10.1007/s40200-020-00539-8

Cited by 23 publications

(26 citation statements)

References 26 publications

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“… 46 So far, several studies have narrowed the path, linking DM with COVID‐19 progression. 47 , 48 The significant association of DM with COVID‐19 severity in our study is similar to the results of a pooled analysis, which demonstrated that patients with DM had significantly higher risks of disease severity and mortality. 47 Across sex disparity, Galbadage and colleagues 49 indicated male sex as an essential risk factor for COVID‐19 progression.…”

Section: Discussionsupporting

confidence: 89%

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

et al. 2021

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Background: We aimed to ascertain risk indicators of in-hospital mortality and severity as well as to provide a comprehensive systematic review and metaanalysis to investigate the prognostic significance of the prognostic nutrition index (PNI) as a predictor of adverse outcomes in hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: In this cross-sectional study, we studied patients with COVID-19 who were referred to our hospital from February 16 to November 1, 2020. Patients with either a real-time reverse-transcriptase polymerase chain reaction test that was positive for COVID-19 or high clinical suspicion based on the World Health Organization (WHO) interim guidance were enrolled. A parallel systematic review/meta-analysis (in PubMed, Embase, and Web of Science) was performed. Results: A total of 504 hospitalized COVID-19 patients were included in this study, among which 101 (20.04%) patients died during hospitalization, and 372

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Section: Discussionsupporting

confidence: 89%

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

et al. 2021

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“…Individuals with comorbidities such as obesity, diabetes, chronic respiratory disease, cardiovascular disease and other immunocompromising conditions are facing higher risks in developing the severe form of SARS‐CoV‐2 infections. 4 , 5 , 6 , 7 , 8 , 9 For the past months, medical therapies to treat Covid‐19 have been growing and evolving rapidly, ranging from supportive care, antivirals, anti‐inflammatory agents and possible supplementations such as vitamin D. 10 , 11 , 12 , 13 Several studies have shown that vitamin D has antiviral properties and potential roles against acute lung injury or ARDS, making large interest on vitamin D has rapidly emanated even in the early beginning of pandemic. 14 , 15 Low vitamin D serum levels is associated with an increase in inflammatory cytokine levels and significant increase of risk to develop pneumonia and viral respiratory tract infections, which both contribute to the development of ARDS.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D supplementation and Covid‐19 outcomes: A systematic review, meta‐analysis and meta‐regression

Hariyanto

Intan

Hananto

et al. 2021

Reviews in Medical Virology

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Summary Vitamin D has many protective properties and potential role against acute lung injury. Low serum vitamin D is associated with high risk of pneumonia and development of acute respiratory distress syndrome. This study sought to analyse the efficacy of vitamin D in improving the outcomes of coronavirus disease 2019 (Covid‐19) patients. Using specific keywords, we comprehensively searched the potential articles on PubMed, Europe PMC and ClinicalTrials.gov database until 8th May 2021. All published studies on Covid‐19 and vitamin D were retrieved. Statistical analysis was conducted using Review Manager 5.4 software. A total of 11 studies with 22,265 Covid‐19 patients were included in the meta‐analysis. Our data suggested that vitamin D supplementation was associated with reduction in intensive care unit admission rate (OR 0.27; 95% CI: 0.09–0.76, p = 0.010, I 2 = 70%, random‐effect modelling); reduction of the need for mechanical ventilation (OR 0.34; 95% CI: 0.16–0.72, p = 0.005, I 2 = 61%, random‐effect modelling) and reduction of mortality from Covid‐19 (OR 0.37; 95% CI: 0.21–0.66, p < 0.001, I 2 = 50%, random‐effect modelling). Further analysis showed that the associations were influenced by age ( p = 0.020). Our study suggests that vitamin D supplementation may offer beneficial effects on Covid‐19 outcomes. However, more randomized clinical trials are required to confirm this conclusion.

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“…Of note, according to the reports of the International Diabetes Federation (IDF), the Middle East and North Africa (MENA) region has the highest world age-standardized DM prevalence [ 20 ]. Among countries in the MENA, Iran has faced essential challenges for controlling the imposed burden of DM during the COVID-19 pandemic [ 21 ]. In fact, it has been demonstrated that COVID-19 and DM could have reciprocal interactions [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among countries in the MENA, Iran has faced essential challenges for controlling the imposed burden of DM during the COVID-19 pandemic [ 21 ]. In fact, it has been demonstrated that COVID-19 and DM could have reciprocal interactions [ 21 , 22 ]. The COVID-19 pandemic could restrict the resources for those with DM [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Dissection of non-pharmaceutical interventions implemented by Iran, South Korea, and Turkey in the fight against COVID-19 pandemic

Keykhaei

Koolaji

Mohammadi

et al. 2021

J Diabetes Metab Disord

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Purpose The novel coronavirus disease 2019 (COVID-19) has imposed a great global burden on public health. As one of the most affected countries, Iran has tackled emerging challenges in the path to overcoming the epidemic, with three peaks of the disease propagation as of February 19, 2020. To flatten the curve of the COVID-19 pandemic, most countries have implemented bundles of intrusive, sometimes extremely stringent non-pharmaceutical interventions (NPIs). In this communication, we have dissected the effectiveness of NPIs and compared the strategies implemented by Iran, Turkey, and South Korea to mitigate the disease’s spread. Methods We searched online databases via PubMed, Web of Knowledge, and Scopus. Titles/abstracts and full-texts were screened by two reviewers and discrepancies were resolved upon discussion. Results Our results provide insights into five domains: prevention, screening, in-patient and out-patient facilities, governance, and management of diabetes mellitus. Analysis of previous efforts put in place illustrates that by fostering efficient social distancing measures, increasing the capability to perform prompt polymerase chain reaction tests, applying smart contact tracing, and supplying adequate personal protective equipment, Turkey and South Korea have brought the epidemic sub-optimally under control. Conclusion From the perspective of policymakers, these achievements are of utmost importance given that attaining the aspirational goals in the management of the COVID-19 necessities a suitable adjustment of previous successful strategies. Hence, policymakers should be noticed that a suitable combination of NPIs is necessary to stem the disease’s propagation.

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Effects of Akkermansia muciniphila and Faecalibacterium prausnitzii on serotonin transporter expression in intestinal epithelial cells

Cited by 23 publications

References 26 publications

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

Vitamin D supplementation and Covid‐19 outcomes: A systematic review, meta‐analysis and meta‐regression

Dissection of non-pharmaceutical interventions implemented by Iran, South Korea, and Turkey in the fight against COVID-19 pandemic

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