Effects of aging on the circadian rhythm  of wheel-running activity in C57BL/6 mice

Valentinuzzi, Verónica Sandra; Scarbrough, Kathryn; Takahashi, Joseph S.; Turek, Fred W.

doi:10.1152/ajpregu.1997.273.6.r1957

Cited by 185 publications

(217 citation statements)

References 20 publications

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“…These studies extended over several months such that the younger and older cohorts had reached the ages of 8-9 and 28-29 months, respectively, upon completion of the evaluation. Consistent with published observations (Valentinuzzi et al 1997), the nocturnally active older animals initiated wheel-running activity significantly later than their younger controls following the onset of the lights out period. Furthermore, in contrast to the younger cohort, the older animals continued their wheel running after the lights were turned on.…”

Section: Statistical Methods Values Are Presented As the Mean ± Resultssupporting

confidence: 91%

Biological aging alters circadian mechanisms in murine adipose tissue depots

Sutton

Ptitsyn

Floyd

et al. 2012

AGE

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Biological aging alters the metabolism and volume of adipose tissue depots. Recent evidence suggests that circadian mechanisms play a role in promoting adipogenesis, obesity, and lipodystrophy.The current study compared cohorts of younger (5-9 months) and older (24-28 months) C57BL/6 mice as a function of biological age and circadian time. Advanced age significantly reduced the weight of the AGE (2013) 35:533-547 DOI 10.1007 Electronic supplementary material The online version of this article (doi:10.1007/s11357-012-9389-7) contains supplementary material, which is available to authorized users. brown, epididymal, inguinal, and retroperitoneal adipose depots but not total body weight. The older mice reduced their physical activity by >50% and delayed their activity initiation after light offset. The expressed transcriptome in brown and white adipose depots and liver of both cohorts displayed evidence of circadian rhythmicity; however, the oscillating mRNAs differed significantly between age groups and across tissues. The amplitude of Cry1, a component of the negative arm of the circadian apparatus, and downstream regulators such as Rev-erbα were elevated in the older relative to the younger cohorts as a function of circadian time. Overall, transcript levels differed significantly for 557 (inguinal adipose), 1,016 (liver), and 1,021 (brown adipose) expressed sequences between the cohorts as a function of age. These included transcripts encoding proteins within the canonical and non-canonical Wnt pathways. Since the Wnt pathway regulates adipose stem cell differentiation and shares a critical enzyme, glycogen synthase kinase 3β, with the circadian mechanism, the intersection between these two fundamental regulatory mechanisms merits further investigation with respect to biological aging of adipose tissues.

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Section: Statistical Methods Values Are Presented As the Mean ± Resultssupporting

confidence: 91%

Biological aging alters circadian mechanisms in murine adipose tissue depots

Sutton

Ptitsyn

Floyd

et al. 2012

AGE

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“…Earlier work has show disruption to a number of circadian parameters in C57BL/6 mice with senescence in vivo (Valentinuzzi et al 1997). This is the first report of changes to the phase shifting ability of neurotransmitters within the mouse SCN in vitro with age.…”

Section: Discussionmentioning

confidence: 49%

Circadian clock resetting in the mouse changes with age

Biello

2009

AGE

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The most widely recognised consequence of normal age-related changes in biological timing is the sleep disruption that appears in old age and diminishes the quality of life. These sleep disorders are part of the normal ageing process and consist primarily of increased amounts of wakefulness and reduced amounts of deep sleep. Changes in the amplitude and timing of the sleep-wake cycle appear to represent, at least in part, a loss of effective circadian regulation of sleep. Understanding alterations in the characteristics of stimuli that help to consolidate internal rhythms will lead to recommendations to improve synchronisation in old age. Converging evidence from both human and animal studies indicate that senescence is associated with alterations in the neural structure thought to be primarily responsible for the generation of the circadian oscillation, the suprachiasmatic nuclei (SCN). Work has shown that there are changes in the anatomy, physiology and ability of the clock to reset in response to stimuli with age. Therefore it is possible that at least some of the observed age-related changes in sleep and circadian timing could be mediated at the level of the SCN. The SCN contain a circadian clock whose activity can be recorded in vitro for several days. We have tested the response of the circadian clock to a number of neurochemicals that reset the clock in a manner similar to light, including glutamate, N-methyl-D-aspartate (NMDA), gastrin-releasing peptide (GRP) and histamine (HA). In addition, we have also tested agents which phase shift in a pattern similar to behavioural 'non-photic' signals, including neuropeptide Y (NPY), serotonin (5HT) and gamma-aminobutyric acid (GABA). These were tested on the circadian clock in young and older mice (approximately 4 and 15 months old). We found deficits in the response to specific neurochemicals but not to others in our older mice. These results indicate that some changes seen in the responsiveness of the circadian clock to light with age may be mediated at the level of the SCN. Further, the responsiveness of the circadian clock with age is attenuated to some, but not all stimuli. This suggests that not all clock stimuli loose their effectiveness with age, and that it may be possible to compensate for deficits in clock performance by enhancing the strength of those stimulus pathways which are intact.

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“…(Zee et al, 1992;Penev et al, 1997;Valentinuzzi et al, 1997;Mailloux et al, 1999;Zhang et al, 2000)), confirming rhythm disturbances such as an increased fragmentation and decreased amplitude of the daily locomotor activity rhythm, as well as a decreased precision in the onset of activity phase. Previous work in rodents and primates indicates that the sensitivity of the circadian timing system to short-term manipulation of light…”

Section: Introductionmentioning

confidence: 73%

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

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To cite this version:Fabienne Aujard, Florence Cayetanot, Jérémy Terrien, Eus J.W. Van Someren. Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate. Experimental Gerontology, Elsevier, 2007, 42 (11) ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ABSTRACTAdaptation of physiological and behavioral functions to seasonal changes in daylength is of major relevance for optimal fitness and survival. Because aging is characterized by changes in biological rhythms, it may be hypothesized that old animals fall short of showing a full adaptation to prolonged changes in the duration of daily light exposure, as naturally occurring in relation to season in younger individuals. To test this hypothesis, we analyzed changes in the patterns of daily locomotor activity and body temperature rhythms of young and old mouse lemurs (Microcebus murinus, Primates) exposed to short and long daylengths. The effect of an increase in the duration of daily light exposure was attenuated in old animals, as compared to younger lemurs. Although some age-related differences in the locomotor activity rhythm could be seen under exposure to short daylength, they were predominant under long daylength. Some mechanisms allowing adaptation to changing day length thus seem to be impaired at old age. Changes in coupling of circadian oscillators to the light-dark cycle and disturbances in the physiological responses to change in light duration should be further investigated.

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Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice

Cited by 185 publications

References 20 publications

Biological aging alters circadian mechanisms in murine adipose tissue depots

Biological aging alters circadian mechanisms in murine adipose tissue depots

Circadian clock resetting in the mouse changes with age

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

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