Effects of aging on motor cortex excitability

Oliviero, Antonio; Profice, Paolo; Tonali, P.; Pilato, Fabio; Saturno, E.; Dileone, M.; Ranieri, Federico; Lazzaro, Vincenzo Di

doi:10.1016/j.neures.2006.02.002

Cited by 253 publications

(233 citation statements)

References 18 publications

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“…Within the current study, SICI in resting muscle was not different between young and old adults, suggesting that resting post-synaptic GABAA mediated inhibitory tone in motor cortex is maintained with age [7]. This supports previous investigations from within our lab [20,[34][35][36], and from elsewhere [37][38][39], but is in contrast to reports of reduced [23,40,41] or increased [19,42] SICI with age. The reasons for these inconsistencies are currently unclear, but likely relate to variations in subject characteristics and methodological approach [20].…”

Section: Effects Of Age On Short-interval Intracortical Inhibitionsupporting

confidence: 90%

“…However, the majority of studies reporting age-related changes in the CSP suggest a reduced duration with age [24,38], whereas our observed changes in LICI-SICI interactions in older adults could only be explained by an increased CSP duration with advancing age. It therefore seems unlikely that these changes in LICI-SICI interactions were confounded by CSP duration, but instead reflect an age-related reduction in the activation of pre-synaptic GABAB receptors when performing isolated index finger abductions.…”

Section: And Are Reduced In Individuals Withcontrasting

confidence: 71%

“…One possible reason for these observed changes in LICI-SICI interactions could be due to age-related differences in CSP duration [19,24,38]. However, the majority of studies reporting age-related changes in the CSP suggest a reduced duration with age [24,38], whereas our observed changes in LICI-SICI interactions in older adults could only be explained by an increased CSP duration with advancing age.…”

Section: And Are Reduced In Individuals Withmentioning

confidence: 56%

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Age-related Differences in Pre- and Post-synaptic Motor Cortex Inhibition are Task Dependent

2015

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In all cases accepted manuscripts should: link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Embargo 1935-861X Brain Stimulation 12 May 2017Age-related differences in pre-and post-synaptic motor cortex inhibition are task dependent Age-and task-related changes in intracortical inhibitionPage 2 AbstractBackground: Previous research has shown age-related differences in short-(SICI) and long-

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Section: Effects Of Age On Short-interval Intracortical Inhibitionsupporting

confidence: 90%

Section: And Are Reduced In Individuals Withcontrasting

confidence: 71%

Section: And Are Reduced In Individuals Withmentioning

confidence: 56%

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Age-related Differences in Pre- and Post-synaptic Motor Cortex Inhibition are Task Dependent

2015

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“…This is a significant issue as it relates to the development of translational therapies; with numerous studies having identified that recovery mechanisms in aged are significantly different to those of younger animals. 18,29,30 Despite, the potential implications concerning successful translation, there have been surprisingly few studies that evaluate the efficacy of pharmaceutical interventions in aged animals, particularly in the context of stroke recovery. As we had previously shown the benefits of CX1837 in younger animals we wished to determine whether the compound has the same globally beneficial effects in aged (24 months old) mice.…”

Section: Discussionmentioning

confidence: 99%

Combined Ampakine and BDNF Treatments Enhance Poststroke Functional Recovery in Aged Mice via AKT-CREB Signaling

Clarkson

Parker

Nilsson

et al. 2015

J Cereb Blood Flow Metab

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Cerebral ischemia results in damage to neuronal circuits and lasting impairment in function. We have previously reported that stimulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors with the ampakine, CX1837, increases brainderived neurotrophic factor (BDNF) levels and affords significant motor recovery after stroke in young mice. Here, we investigated whether administration of CX1837 in aged (24 months old) mice was equally effective. In a model of focal ischemia, administration of CX1837 from 5 days after stroke resulted in a small gain of motor function by week 6 after stroke. Mice that received a local delivery of BDNF via hydrogel implanted into the stroke cavity also showed a small gain of function from 4 to 6 weeks after stroke. Combining both treatments, however, resulted in a marked improvement in motor function from 2 weeks after insult. Assessment of peri-infarct tissue 2 weeks after stroke revealed a significant increase in p-AKT and p-CREB after the combined drug treatment. Using the pan-AKT inhibitor, GSK-690693, or deletion of CREB from forebrain neurons using the CREB-flox/CAMKii-cre mice, we were able to block the recovery of motor function. These data suggest that combined CX1837 and local delivery of BDNF are required to achieve maximal functional recovery after stroke in aged mice, and is occurring via the AKT-GSK3-CREB signaling pathway.

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“…Previous literature suggests contradictory effects of age on SICI and LICI during both relaxation [27,29,[49][50][51][52][53][54][55][56][57][58][59][60][61][62] and isometric muscle activation [30,33,63], with variations in methodology and subject characteristics likely contributing to this heterogeneity. Despite this, as the conditioning stimulus intensity was adjusted to produce 50% inhibition of the test MEP during postural contractions, our findings could not have been confounded by any age-related differences in inhibition at baseline.…”

Section: Age-related Differences In Gabaergic Inhibition During Movemmentioning

confidence: 99%

Intracortical Inhibition Assessed with Paired-Pulse Transcranial Magnetic Stimulation is Modulated during Shortening and Lengthening Contractions in Young and Old Adults

Opie

Semmler

2016

Brain Stimulation

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In all cases accepted manuscripts should: link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Embargo 1935-861X Brain Stimulation 129 May 2017 Age-and movement-related changes in intracortical inhibitionPage 2 AbstractBackground: The modulation of intracortical inhibition is thought to be impaired in older

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Effects of aging on motor cortex excitability

Cited by 253 publications

References 18 publications

Age-related Differences in Pre- and Post-synaptic Motor Cortex Inhibition are Task Dependent

Age-related Differences in Pre- and Post-synaptic Motor Cortex Inhibition are Task Dependent

Combined Ampakine and BDNF Treatments Enhance Poststroke Functional Recovery in Aged Mice via AKT-CREB Signaling

Intracortical Inhibition Assessed with Paired-Pulse Transcranial Magnetic Stimulation is Modulated during Shortening and Lengthening Contractions in Young and Old Adults

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