Effects of aging on food-entrained circadian rhythms in the rat

Mistlberger, Ralph E.; Houpt, Thomas A.; Moore‐Ede, Martin C.

doi:10.1016/0197-4580(90)90027-w

Cited by 21 publications

(6 citation statements)

References 24 publications

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“…In older mice, there was no difference between the sexes for induction or maintenance of FAA, but it would be interesting to examine much older mice (1.5–2 years). Prior work in rats has shown some deterioration of food rhythms in aged male rats [ 22 ]. Taken together, our experiments suggest that combinatorial effects of developmental, hormonal, sex-chromosome related, or other unidentified factor(s) are responsible for the sex difference in circadian entrainment to scheduled feeding.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in circadian food anticipatory activity are not altered by individual manipulations of sex hormones or sex chromosome copy number in mice

et al. 2018

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Recent studies in mice have demonstrated a sexual dimorphism in circadian entrainment to scheduled feeding. On a time restricted diet, males tend to develop food anticipatory activity (FAA) sooner than females and with a higher amplitude of activity. The underlying cause of this sex difference remains unknown. One study suggests that sex hormones, both androgens and estrogens, modulate food anticipatory activity in mice. Here we present results suggesting that the sex difference in FAA is unrelated to gonadal sex hormones. While a sex difference between males and females in FAA on a timed, calorie restricted diet was observed there were no differences between intact and gonadectomized mice in the onset or magnitude of FAA. To test other sources of the sex difference in circadian entrainment to scheduled feeding, we used sex chromosome copy number mutants, but there was no difference in FAA when comparing XX, XY-, XY-;Sry Tg, and XX;Sry Tg mice, demonstrating that gene dosage of sex chromosomes does not mediate the sex difference in FAA. Next, we masculinized female mice by treating them with 17-beta estradiol during the neonatal period; yet again, we saw no difference in FAA between control and masculinized females. Finally, we observed that there was no longer a sex difference in FAA for older mice, suggesting that the sex difference in FAA is age-dependent. Thus, our study demonstrates that singular manipulations of gonadal hormones, sex chromosomes, or developmental patterning are not able to explain the difference in FAA between young male and female mice.

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Section: Discussionmentioning

confidence: 99%

Sex differences in circadian food anticipatory activity are not altered by individual manipulations of sex hormones or sex chromosome copy number in mice

et al. 2018

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“…However, the mechanisms of this phenomenon remain to be fully elucidated. A few studies on the food entrainment in aged rodents produced conflicting results, some suggesting that this rhythm deteriorates with age [21], [22]. However, others did not confirm this conclusion [23].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Aging in Zebrafish

et al. 2006

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BackgroundAge-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and environmental factors that determine the deterioration or preservation of cognitive abilities throughout life.Methodology/Principal FindingsBehavior of wild-type, mutant and gamma-irradiated zebrafish (Danio rerio) was documented using image-analysis technique. Conditioned responses to spatial, visual and temporal cues were investigated in young, middle-aged and old animals. The results demonstrate that zebrafish aging is associated with changes in cognitive responses to emotionally positive and negative experiences, reduced generalization of adaptive associations, increased stereotypic and reduced exploratory behavior and altered temporal entrainment. Genetic upregulation of cholinergic transmission attenuates cognitive decline in middle-aged achesb55/+ mutants, compared to wild-type siblings. In contrast, the genotoxic stress of gamma-irradiation accelerates the onset of cognitive impairment in young zebrafish.Conclusions/SignificanceThese findings would allow the use of powerful molecular biological resources accumulated in the zebrafish field to address the mechanisms of cognitive senescence, and promote the search for therapeutic strategies which may attenuate age-related cognitive decline.

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“…Research examining the potency of restricted food delivery as a zeitgeber across the lifespan suggests that responsiveness to this nonphotic time cue may only be modestly affected by age. For example, similarly to young rats, older rats (approximately 24 months) will still develop anticipatory bouts of activity for food presentation on a restricted schedule (146,147).…”

Section: Sensitivity To Zeitgebersmentioning

confidence: 99%