Effects of aging on executive functioning and mesocorticolimbic dopamine markers in male Fischer 344 × brown Norway rats

Tomm, Ryan J.; Tse, Maric T.; Tobiansky, Daniel J.; Schweitzer, Helen R.; Soma, Kiran K.; Floresco, Stan

doi:10.1016/j.neurobiolaging.2018.08.020

Cited by 16 publications

(27 citation statements)

References 69 publications

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“…For example, it is widely accepted that neuroinflammation can induce cognitive decline, and, as TgF344‐AD rats show a neuroinflammatory response, especially in the hippocampus at 12 months of age, 44 it is possible that it has an impact on the learning capacity of rats. Among the neurotransmission systems which also affect cognitive capacities, it has been shown that an alteration in the dopamine (DA) system can induce memory dysfunctions 45,46 . Moreover, in AD patients as in different animal models, disorders of the DA system are reported 2,4,47,48 .…”

Section: Discussionmentioning

confidence: 99%

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344‐AD rat model of Alzheimer's disease

Tournier

Barca

Fall

et al. 2020

Genes Brain and Behavior

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Alzheimer's disease (AD) is characterized by cognitive disorders and alterations of behavioral traits such as anhedonia and anxiety. Contribution of nonphysiological forms of amyloid and tau peptides to the onset of neurological dysfunctions remains unclear because most preclinical models only present one of those pathological AD‐related biomarkers. A more recently developed model, the TgF344‐AD rat has the advantage of overexpressing amyloid and naturally developing tauopathy, thus making it close to human familial forms of AD. We showed the presence of a learning dysfunction in a reference memory test, without spatial working memory impairment but with an increase in anxiety levels and a decrease in motivation to participate in the test. In the sucrose preference test, TgF344‐AD rats did not show signs of anhedonia but did not increase the volume of liquid consumed when the water was replaced by sucrose solution. These behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are predominant in the hippocampus and the entorhinal cortex. Within the hippocampus itself, amyloid accumulation is heterogenous between the subiculum, the dorsal hippocampus and the ventral hippocampus. Thus, our data demonstrated heterogeneity in the appearance of various behavioral and neurochemical markers in the TgF344‐AD rat. This multivariate analysis will therefore make it possible to define the stage of the pathology, to measure its evolution and the effects of future therapeutic treatments.

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Section: Discussionmentioning

confidence: 99%

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344‐AD rat model of Alzheimer's disease

Tournier

Barca

Fall

et al. 2020

Genes Brain and Behavior

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“…To analyse difference in TH staining, mean greyscale values of the ROIs were compared across groups, similar to previous studies (Mosedale et al 1996, Matkowskyj et al 2000. We also validated this method by comparing it to our previous method, in which we quantified the area of the ROI with colorimetric signal above a threshold based on multiple background measurements (Heimovics et al 2012, Tomm et al 2018. For FOSB-ir quantification, D J Tobiansky et al…”

Section: Immunohistochemistry and Quantification For Th And Fosbmentioning

confidence: 98%

“…A complete series was utilized for each protein of interest, and all subjects were processed together. The immunostaining protocol for TH ((1:1000); clone LNC1, mouse MAB; Millipore; Cat# MAB318) is described previously (Heimovics et al 2012, Tomm et al 2018. Briefly, free-floating sections were incubated in 0.5% H 2 O 2 for 30 min at room temperature (RT), followed by an incubation in blocking solution (2% normal goat serum (NGS) in PBS) for 2 h at RT.…”

Section: Immunohistochemistry and Quantification For Th And Fosbmentioning

confidence: 99%

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

Tobiansky

Kachkovski

Enos

et al. 2020

Journal of Endocrinology

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Sucrose consumption is associated with type 2 diabetes, cardiovascular disease, and cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects on metabolic, endocrine, and neural physiology. It remains unclear how consumption of sucrose affects parous females, especially in brain circuits that mediate food consumption and reward processing. Here, we examine whether a human-relevant level of sucrose before, during, and after pregnancy (17–18 weeks total) influences metabolic and neuroendocrine physiology in female rats. Females were fed either a control diet or a macronutrient-matched, isocaloric sucrose diet (25% of kcal from sucrose). Metabolically, sucrose impairs glucose tolerance, increases liver lipids, and increases a marker of adipose inflammation, but has no effect on body weight or overall visceral adiposity. Sucrose also decreases corticosterone levels in serum but not in the brain. Sucrose increases progesterone levels in serum and in the brain and increases the brain:serum ratio of progesterone in the mesocorticolimbic system and hypothalamus. These data suggest a dysregulation of systemic and local steroid signalling. Moreover, sucrose decreases tyrosine hydroxylase (TH), a catecholamine-synthetic enzyme, in the medial prefrontal cortex. Finally, sucrose consumption alters the expression pattern of FOSB, a marker of phasic dopamine signalling, in the nucleus accumbens. Overall, chronic consumption of sucrose at a human-relevant level alters metabolism, steroid levels, and brain dopamine signalling in a female rat model.

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“…This is in concert with the ability of other palatable tastants (including, but not limited to, fat, sucrose, and select amino acids) to have a positive gustatory effect when presented as a component of both liquid and solid foods [34]. The fact that not only adolescent and adult animals, but also the aged ones, readily consume GM and CM suggests that age-related decline in hedonic processing [22,35,36,37] does not completely abolish a drive to eat milk-based diets. Instead, a slightly depressed intake of GM and CM at an old age parallels that reported for sweet solutions, as shown here and by other authors [38,39,40].…”

Section: Discussionmentioning

confidence: 99%

Palatability of Goat’s versus Cow’s Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models

et al. 2019

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Goat’s (GM) and cow’s milk (CM) are dietary alternatives with select health benefits shown in human and animal studies. Surprisingly, no systematic analysis of palatability or preference for GM vs. CM has been performed to date. Here, we present a comprehensive investigation of short-term intake and palatability profiles of GM and CM in laboratory mice and rats. We studied consumption in no-choice and choice scenarios, including meal microstructure, and by using isocaloric milks and milk-enriched solid diets. Feeding results are accompanied by qPCR data of relevant genes in the energy balance-related hypothalamus and brain stem, and in the nucleus accumbens, which regulates eating for palatability. We found that GM and CM are palatable to juvenile, adult, and aged rodents. Given a choice, animals prefer GM- to CM-based diets. Analysis of meal microstructure using licking patterns points to enhanced palatability of and, possibly, greater motivation toward GM over CM. Most profound changes in gene expression after GM vs. CM were associated with the brain systems driving consumption for reward. We conclude that, while both GM and CM are palatable, GM is preferred over CM by laboratory animals, and this preference is driven by central mechanisms controlling eating for pleasure.

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Effects of aging on executive functioning and mesocorticolimbic dopamine markers in male Fischer 344 × brown Norway rats

Cited by 16 publications

References 69 publications

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344‐AD rat model of Alzheimer's disease

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344‐AD rat model of Alzheimer's disease

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

Palatability of Goat’s versus Cow’s Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models

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