Effects of Aging on Angiogenesis

Lähteenvuo, Johanna; Rosenzweig, Anthony

doi:10.1161/circresaha.111.246116

Cited by 235 publications

(186 citation statements)

References 173 publications

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“…Furthermore, mesothelin levels were previously found to be higher in patients with impaired renal function, which is in accordance with our results [29]. Angiogenin and VEGFR1, which had the highest levels in young patients, were linked to angiogenesis and revascularization [30][31][32][33]. Both markers are pathophysiologically involved in vascular repair and cardiac remodeling, both of which are etiological factors for the development of HFrEF.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Acute heart failure in the young: Clinical characteristics and biomarker profiles

Tromp

Meyer

Mentz

et al. 2016

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 92%

“…Both markers are pathophysiologically involved in vascular repair and cardiac remodeling, both of which are etiological factors for the development of HFrEF. Angiogenesis is impaired in the elderly, possibly also contributing to the lower levels of these two biomarkers in the older patients [33].…”

Section: Discussionmentioning

confidence: 99%

Acute heart failure in the young: Clinical characteristics and biomarker profiles

Tromp

Meyer

Mentz

et al. 2016

International Journal of Cardiology

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“…These so-called 'longevity regulatory pathways', include insulin/insulin-like growth factor 1 (IGF-1), the mammalian target of rapamycin (mTOR), AMP-activated kinase (AMPK), and nicotinamide adenine dinucleotide (NAD)+-dependent deacetylases (sirtuins). The CR is extensively-studied longevity intervention and has been shown to increase lifespan in various model organisms, from yeast and the nematode, C. elegans to mice, rats, and rhesus monkeys [54,55].…”

Section: Calorie Restriction and Cr Mimeticsmentioning

confidence: 99%

Aging Heart: Recent Research and Concepts

Nikhra¹

2017

GGS

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Aging, per se, is the most important risk factor for cardiovascular diseases (CVDs). At individual level, it is the most important determinant of cardiovascular (CV) health. There occurs an exponential rise in both the CV risk and the incidence of CV events in older adults parallel with the advancing age. Statically, the older adults (>60 years old) account for more than 80% of coronary heart disease, more than 75% of congestive heart failure, and more than 70% of a trial fibrillation patients [1]. It is estimated that by 2030, approximately 20% of the population will be aged 65 or older, and in this age group, CVDs will amount to over 40% of all deaths [2,3] and rank as the leading cause of disability and sub optimal quality of life during later years.The increased age-dependent exposure time to various risk factors including hypertension, diabetes, hypercholesterolemia and smoking is accompanied by age associated interactions of the intrinsic aging of heart and vasculature with progressive structural changes and functional decline occurring with age. Further, the changes in CV structure and functions due to the intrinsic aging increase susceptibility to oxidative stress related injury and contribute to increased CV morbidity and mortality. These changes alter the substrate on which CVDs are superimposed in several ways, altering the occurrence, presentation, and manifestations of heart disease in older adults and lowering the threshold for clinically significant signs and symptoms. The aging, thus, has an impact on the risk and severity of the clinical manifestations for CVDs; which is true for clinically overt disease as well as subclinical or occult diseases, such as silent coronary atherosclerosis.To prove this point, various studies including the Framingham Heart Study [4] and the Baltimore Longitudinal Study on Aging highlight the changes that occur with age in healthy humans, and their association and relevance to the increased incidence of LVH, chronic heart failure, and AF seen with advancing age [5]. With aging, the declining cardio protective systems and increasing disease processes predispose to the development of heart failure, which is largely a disease of the elderly. About 50% of all heart There occurs an exponential rise in both the CV risk and the incidence of CV events in older adults parallel with the advancing age. The aging process and its impact, in turn, depend on many factors, from individual genetic constitution to his or her patterns of living which include the environment and lifestyle influencing the risk factors variously.Pathophysiology of CV aging: Some individuals may age without much deterioration in body organs and systems, whereas others may be ridden with the extreme age-associated changes. Further, the aging process may affect some body systems more severely whereas others are spared from a serious disability. Thus, aging is associated with a progressive but varying decline in numerous physiological functions, and significantly affects the body organs and various systems i...

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“…Aging is related to dramatic structural and functional alterations in both cardiac chambers and blood vessels, which can explain the age-related increase in cardiovascular risk [163,164].…”

Section: The Roles Of H 2 S and No In Agingmentioning

confidence: 99%

Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

Altaany¹,

Moccia²,

Munaron³

et al. 2014

CMC

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The endothelium is a cellular monolayer that lines the inner surface of blood vessels and plays a central role in the maintenance of cardiovascular homeostasis by controlling platelet aggregation, vascular tone, blood fluidity and fibrinolysis, adhesion and transmigration of inflammatory cells, and angiogenesis. Endothelial dysfunctions are associated with various cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and cardiovascular complications of diabetes. Numerous studies have established the antiinflammatory, anti-apoptotic, and anti-oxidant effects of hydrogen sulfide (H 2 S), the latest member to join the gasotransmitter family along with nitric oxide and carbon monoxide, on vascular endothelium. In addition, H 2 S may prime endothelial cells (ECs) toward angiogenesis and contribute to wound healing, aside to its well-known ability to relax vascular smooth muscle cells (VSMCs), thereby reducing blood pressure. Finally, H 2 S may inhibit VSMC proliferation and platelet aggregation. Consistently, a deficit in H 2 S homeostasis is involved in the pathogenesis of atherosclerosis and of hyperglycaemic endothelial injury. Therefore, the application of H 2 S-releasing drugs or using gene therapy to increase endogenous H 2 S level may help restore endothelial function and antagonize the progression of cardiovascular diseases. The present article reviews recent studies on the role of H 2 S in endothelial homeostasis, under both physiological and pathological conditions, and its putative therapeutic applications. Endothelial structure and functionThe endothelium lines the luminal surface of the entire vascular tree and the cardiac chambers, where it is termed endocardium. As a consequence, the endothelium presents a rather broad extension (300 to 1000 m 2 ) and weight (1.5 kg), achieving sizes comparable to other vital organs of the human body [1,2]. The endothelium can, therefore, be regarded as a real "organ spread across the organism" [3] and, as such, not only it is important for the regulation of local tissue functions, but also for maintaining the whole organism homeostasis [4]. Vascular endothelial cells (ECs) possess a polarized architecture: their luminal membrane is directly exposed to hematic constituents and circulating cells, while the basolateral surface is separated from surrounding tissues by a glycoprotein basement membrane -the sub-endothelial basement -which is formed by fibronectin, laminin, and collagen and is secreted by ECs themselves [2].Heterogeneity is, however, the hallmark of endothelium. ECs differ in morphology, function, and gene expression profile, so that even neighbouring cells from the same organ and blood vessel type exhibit distinct features [4]. For instance, vascular ECs may vary in size, shape, thickness and position of the nucleus. Albeit oriented along direction of blood flow, to attenuate the impact of shear stress forces on the vascular wall, microvascular ECs are rather thin (0.1 µm) and spindle-like, whilst their macrovascul...

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Effects of Aging on Angiogenesis

Cited by 235 publications

References 173 publications

Acute heart failure in the young: Clinical characteristics and biomarker profiles

Acute heart failure in the young: Clinical characteristics and biomarker profiles

Aging Heart: Recent Research and Concepts

Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

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