Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults

Yamamoto, Hiroyuki; Sohmiya, Motoi; Oka, Nobuyuki; Kato, Yuzuru

doi:10.1530/acta.0.1240497

Cited by 101 publications

(63 citation statements)

References 21 publications

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“…However, in contrast to recently published studies, we found no significant gender differences in IGF1 levels in the middle-aged-and oldest-old subjects (37,38). Gender differences were present for IGFBP3 levels consistent with the findings of previous studies (39).…”

Section: Discussionsupporting

confidence: 73%

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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Objective: In aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged-and oldest-old subjects. Design: Cross-sectional analysis in two different cohorts composed of middle-aged-(nZ672, mean 63.9G6.7 years) and oldest-old subjects (nZ272, all 89 years). Methods: Handgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately. Results: IGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged-and oldest-old women (both, P!0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldestold men (PZ0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (PZ0.002). Conclusion: The significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

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Section: Discussionsupporting

confidence: 73%

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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“…The minimum detectable quantity was 5 IU/l. Plasma IGF-I levels were measured by speci®c RIA after acid± ethanol extraction as previously described (18). Plasma and urinary Cr were measured by an autoanalyzer (TBA50S, Toshiba, Tokyo, Japan).…”

Section: Assaysmentioning

confidence: 99%

Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

Sohmiya

Ishikawa

Kato

1998

European Journal of Endocrinology

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We have investigated the effect of human GH on erythropoietin (EPO) secretion in eight anemic patients with chronic renal failure (CRF) (three males and ®ve females, aged from 46 to 83 years). Recombinant human GH was infused subcutaneously at a¯ow rate of 2 mg/kg body weight per 0.1 ml/h for 72 h using a portable infusion pump. Blood samples were obtained immediately before and 2, 4,6,12,24,36, 48, 60, 72, 84, 96, 108, 120 and 168 h after the start of GH infusion. Storage urine samples were obtained before and 24, 48 and 72 h after the start of the infusion. The mean (6 S.E.M.) basal plasma GH levels increased from 1.9 6 0.3 to 18.8 6 0.7 mg/l during the GH infusion. Plasma IGF-I levels increased 12 h after the start of GH treatment and the mean peak values of 403.6 6 38.5 mg/l were obtained at 72 h. Plasma EPO levels increased 6 h after the start of GH infusion, and the peak values of 38.4 6 11.6 IU/l were obtained at 96 h (P < 0.05 vs basal values 24.5 6 7.2 IU/l). Reticulocyte counts increased from 28.7 6 5.2´10 3 /ml to 40.3 6 8.0´10 3 /ml at 108 h, 43.6 6 9.2´10 3 /ml at 120 h and 41.7 6 7.7´10 3 /ml at 160 h (P < 0.05). Serum urea nitrogen decreased at 72 h (P < 0.05), whereas there was no signi®cant change in urinary excretion of nitrogen. Hemoglobin levels were not signi®cantly changed throughout the experimental period. These ®ndings indicate that human GH has a stimulating effect on EPO secretion in anemic patients with CRF.

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“…Comparison tests of continuous variables were performed using an unpaired t-test or one-way ANOVA followed with Turkey's post hoc test. It is known that total IGF-I concentration declines with increased age in adults [22,23]. In the present study, all analyses regarding serum IGF-I levels were adjusted for age.…”

Section: Statistical Analysesmentioning

confidence: 97%

DNA Methylation Analysis of the Insulin-like Growth Factor-1 (IGF1) Gene in Swedish Men with Normal Glucose Tolerance and Type 2 Diabetes

Gu¹

2014

J Diabetes Metab

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Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults

Cited by 101 publications

References 21 publications

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

DNA Methylation Analysis of the Insulin-like Growth Factor-1 (IGF1) Gene in Swedish Men with Normal Glucose Tolerance and Type 2 Diabetes

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