Effects of Agents, Used to Treat Bleeding Disorders, on Bleeding Time Prolonged by a Very High Dose of a Direct Thrombin Inhibitor in Anesthesized Rats and Rabbits

Elg, Margareta; Carlsson, Stefan; Gustafsson, David

doi:10.1016/s0049-3848(00)00398-4

Cited by 66 publications

(55 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An in vivo anticoagulant effect of CPUFL was investigated as previously described by Elg et al, 15 with modifications. In this determination, rabbits were put into six groups (n=5) and pre-treated orally with either CPUFL (4, 8, or 12 mg/kg; p.o.…”

Section: Effect Of Cpufl On the Bleeding Timementioning

confidence: 99%

Anticoagulant and antiplatelet properties of the latex of unripe fruits of Carica papaya L. (Caricaceae)

Asare

Koffuor

Nyansah

et al. 2015

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Section: Effect Of Cpufl On the Bleeding Timementioning

confidence: 99%

Anticoagulant and antiplatelet properties of the latex of unripe fruits of Carica papaya L. (Caricaceae)

Asare

Koffuor

Nyansah

et al. 2015

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

“…and 300 mg/kg of TXA were used. Again, similar doses have demonstrated antifibrinolytic activity in rats [23,25,26]. In the liver injury model (n=15/group), doses used were 450 mg/kg and 300 mg/kg of EACA and TXA, respectively.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of FDA-approved hemostatic drugs to improve survival and reduce bleeding in rat models of uncontrolled hemorrhage

et al. 2006

View full text Add to dashboard Cite

“…At day 7 blood samples were collected from each animal of all groups and were used for the determination of prothrombin time, activated partial thromboplastin time and platelet count by following standard methods (Jagtap et al, 2012). In addition to this clotting time and bleeding time was also measured by capillary tube and filter paper method respectively (Elg et al, 2001). …”

Section: Effect On Different Coagulation Parameters After Seven Days mentioning

confidence: 99%

Antithrombotic potential of <i>Berberis calliobotrys</i> extract

Alamgeer

Asif

Rasool

2016

Bangladesh J Pharmacol

View full text Add to dashboard Cite

This study was focused with the aim to investigate the antithrombotic potential of Berberis calliobotrys. Aqueous-methanolic extract and various fractions showed significant (p<0.05-0.001) increase in prothrombin, activated partial thromboplastin and clotting time while only aqueous methanolic extract caused clot lysis when added to the blood samples of rabbit and human. In vivo study in rabbits, butanolic fraction (100 mg/kg) produced more significant prolongation in bleeding, prothrombin, activated partial thromboplastin and clotting time. Interestingly butanolic fraction had shown more pronounced effects among all tested extracts both in vivo and in vitro studies. Hence, it was subjected to antilipid peroxidation and phytochemical studies (total falvonoid contents, HPLC-DAD profile, FTIR). In conclusion, B. calliobotrys induce transient changes in the coagulation parameters, may it possess active constituents responsible for its antithrombotic potential. Article Info

show abstract

Effects of Agents, Used to Treat Bleeding Disorders, on Bleeding Time Prolonged by a Very High Dose of a Direct Thrombin Inhibitor in Anesthesized Rats and Rabbits

Cited by 66 publications

References 27 publications

Anticoagulant and antiplatelet properties of the latex of unripe fruits of Carica papaya L. (Caricaceae)

Anticoagulant and antiplatelet properties of the latex of unripe fruits of Carica papaya L. (Caricaceae)

Efficacy of FDA-approved hemostatic drugs to improve survival and reduce bleeding in rat models of uncontrolled hemorrhage

Antithrombotic potential of <i>Berberis calliobotrys</i> extract

Contact Info

Product

Resources

About