Effects of ageing on spermatozoal chromatin and its sensitivity to in vivo and in vitro oxidative challenge in the Brown Norway rat

Zubkova, Ekaterina V.; Robaire, Bernard

doi:10.1093/humrep/del193

Cited by 52 publications

(34 citation statements)

References 71 publications

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“…There are very consistent reports of significantly lower sperm motility in the range of 3-37% when comparing men ≥50 years to men ≤30 years of age (Kidd et al 2001;Zubkova and Robaire 2006). Overall, sperm motility can decline 0.7-4.7% per year, depending on whether motility, progressive motility, or total progressive motility is measured (Eskenazi et al 2003).…”

Section: Markers Of Male Gonadal Agingmentioning

confidence: 82%

“…The decrease in overall sperm motility may correlate with the observed decline in plasma testosterone since sperm maturation and induction of motility in the epididymis both require bioactive testosterone (Henkel et al 2005). Similarly, a negative correlation has been found in normal sperm morphology and age (Zubkova and Robaire 2006). In men ≥50 years, morphologically abnormal sperm increased 4-22% compared with men ≤30 years old (Kidd et al 2001).…”

Section: Markers Of Male Gonadal Agingmentioning

confidence: 92%

“…The proportion of infertility that is attributable to male factors ranges from 25% to 50% (Kidd et al 2001;Agarwal and Said 2003;Eskenazi et al 2003;Larson-Cook et al 2003). There are also findings that link paternal aging to reduced number of live births and increased genetic disorders in offspring (Thacker 2004;Buwe et al 2005;Slama et al 2005;Zubkova and Robaire 2006). The question of how paternal age influences fertility and reproductive outcome is not easily defined nor easily answered since there are no longitudinal studies.…”

Section: Components Of Reproductive Declinementioning

confidence: 99%

“…Instead, the alterations of semen parameters in the aging male are almost always described on the basis of crosssectional sampling (Plas et al 2000). Several recent studies, however, have shown that many aspects of male fertility are affected by aging (Kidd et al 2001;Henkel et al 2005;Zubkova and Robaire 2006).…”

Section: Components Of Reproductive Declinementioning

confidence: 99%

“…Spermiograms provide a composite clinical measure of semen quality (Plas et al 2000). A significant inverse relationship was found between semen volume and age, with a clear decrease (3-30%) between men ≤30 years of age and men ≥50 years of age (Kidd et al 2001;Eskenazi et al 2003;Henkel et al 2005;Zubkova and Robaire 2006). In contrast, much of the literature suggests that sperm concentration remains constant or even increases with age (Kidd et al 2001;Henkel et al 2005).…”

Section: Markers Of Male Gonadal Agingmentioning

confidence: 99%

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Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

Sitzmann

Urbanski

Ottinger

2008

AGE

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Although less dramatic than in females, male mammals experience decreasing reproductive function during aging. In primates, multiple facets of the hypothalamic-pituitary-gonadal axis show evidence of gradual age-related decline, including behavioral, neuroendocrine and endocrine alterations such as decreased testosterone levels, reduced circulating dehydroepiandrosterone sulfate (DHEAS) levels, increased numbers of sperm abnormalities, and a general decline in physiological responses. In this review we consider a range of age-related changes in males. These measures, including more subtle aging characteristics, are interesting additional indices for detecting the timing of age-related changes in behavioral, neuroendocrine, and endocrine responses. Evidence of potential effects of calorie restriction as an intervention in reproductive aging is also discussed. A discernable decline occurs in both metabolic and reproductive endocrine processes during male aging. This cascade of events includes neuroendocrine and behavioral changes; biomarkers such as circulating DHEAS also show clear age-related decline. The varied changes that occur during male aging are considered in the context of primate aging in general.

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Section: Markers Of Male Gonadal Agingmentioning

confidence: 82%

Section: Markers Of Male Gonadal Agingmentioning

confidence: 92%

Section: Components Of Reproductive Declinementioning

confidence: 99%

Section: Components Of Reproductive Declinementioning

confidence: 99%

Section: Markers Of Male Gonadal Agingmentioning

confidence: 99%

See 3 more Smart Citations

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

Sitzmann

Urbanski

Ottinger

2008

AGE

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Age‐related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice

Vogel

Perez

Momand

et al. 2011

Molecular Reproduction Devel

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The prevalence of spontaneous mutations increases with age in the male germline; consequently, older men have an increased risk of siring children with genetic disease due to de novo mutations. The lacI transgenic mouse can be used to study paternal age effects, and in this system, the prevalence of de novo mutations increases in the male germline at old ages. Mutagenesis is linked with DNA repair capacity, and base excision repair, which can ameliorate spontaneous DNA damage, decreases in nuclear extracts of spermatogenic cells from old mice. Mice heterozygous for a null allele of the Apex1 gene, which encodes apurinic/apyrimidinic endonuclease I (APEN), an essential base excision repair enzyme, display an accelerated increase in spontaneous germline mutagenesis early in life. Here, the consequences of lifelong reduction of APEN on genetic instability in the male germline were examined, for the first time, at middle and old ages. Mutation frequency increased earlier in spermatogenic cells from Apex1+/− mice (by 6 months of age). Nuclear DNA damage increased with age in the spermatogenic lineage for both wild-type and Apex1+/− mice. By old age, mutation frequencies were similar for wild-type and APEN-deficient mice. Mitochondrial genome repair also depends on APEN, and novel analysis of mitochondrial DNA damage revealed an increase in the Apex1+/− spermatogenic cells by middle age. Thus, Apex1 heterozygosity results in accelerated damage to mitochondrial DNA and spontaneous mutagenesis, consistent with an essential role for APEN in maintaining nuclear and mitochondrial DNA integrity in spermatogenic cells throughout life.

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Spermatogenesis: An Overview

Sharma

Agarwal

2011

Sperm Chromatin

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Effects of ageing on spermatozoal chromatin and its sensitivity to in vivo and in vitro oxidative challenge in the Brown Norway rat

Abstract: Overall, we show that spermatozoa from older rats have altered chromatin packaging and integrity and that spermatozoa from the cauda epididymidis are more responsive to combined in vivo and in vitro oxidative challenge than spermatozoa from young rats.

Cited by 52 publications

References 71 publications

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

Age‐related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice

Spermatogenesis: An Overview

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