Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in ewes during anestrus and the reproductive season

Forcada, F.; Abecia, J.A.; Casao, A.; Cebrián‐Pérez, J. A.; Muiño‐Blanco, T.; Palacín, I.

doi:10.1016/j.theriogenology.2006.11.002

Cited by 22 publications

(13 citation statements)

References 40 publications

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“…Furthermore, chronically available melatonin negates the antigonadotrophic capability of acute melatonin injections. Forcada et al reported that melatonin can restore the functionality of the neuroendocrine system, after it has been reduced by senescence [25]. One of the most frequently experienced challenges in IVF patients is the oocyte quality.…”

Section: Discussionmentioning

confidence: 99%

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Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Eryılmaz

Devran

Sarıkaya

et al. 2011

J Assist Reprod Genet

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Purpose We aimed to analyse the in vitro fertilizationembryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin. Methods A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups. Results Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively. Conclusion IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

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Section: Discussionmentioning

confidence: 99%

“…The positive effect of melatonin on the reproductive system is well documented [17][18][19][20][21][22][23][24][25].…”

mentioning

confidence: 99%

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Eryılmaz

Devran

Sarıkaya

et al. 2011

J Assist Reprod Genet

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“…Forcada et al (2007) [11] had previously recorded from their studies in sheep that melatonin implant treatments had a positive effect on reproductive parameters (including conception) of nonpregnant ewes at the second or third mating during the breeding season.…”

Section: Discussionmentioning

confidence: 99%

“…A valid use of the understanding of these physiological rythyms could be phase shifting of reproductive activity in camel by the administration of melatonin implants as has been shown for sheep [10,11], goats [12e14] and mares [15]. Because of a longer gestation period in camels [16] camels conceiving during peak breeding season (March) [8] would parturate at a time when the breeding season is approaching an end.…”

Section: Introductionmentioning

confidence: 99%

Sonographic monitoring of early follicle growth induced by melatonin implants in camels and the subsequent fertility

Dholpuria¹,

Vyas

Purohit

et al. 2012

Journal of Ultrasound

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The present study examined the effect of melatonin implants on follicle growth in dromedary camels two months ahead of their natural breeding season (December to March). Female camels (n Z 6) were treated with melatonin implants at the dose rate of 1 implant per 28 kg body weight sc. Control camels (n Z 6) were administered an SC placebo implant of 8 ml vitamin A. Ovarian ultrasonography was performed at weekly interval upto 7 weeks. Camels were mated with virile stud when a follicle (!10 mm) was visible on either of the ovaries. Blood was collected on day 7, 9, 15, 20, 25 and 30 for assay of plasma progesterone and sonography performed at the same time. Small follicles (2-3 mm) appeared around the periphery of ovaries in 83.3% of camels by day 7 and in 100% camels by day 14. By the end of 7th week an ovulatory size follicle (!1.0 cm) could be observed in 83.3% of treated camels, and these camels were mated with virile studs. In control group, small follicles appeared at the periphery of ovaries only in 66.6% camels but did not progress in growth except in one camel (16.6%) however, ovulating size (!10 mm) follicle was not observed in any camel by the end of 7th week. All treated camels ovulated and one treated camel became pregnant while early embryonic death occurred in one camel. Nonepregnant camels of both groups were mated during the breeding season. All camels of treatment group and 33.33% camels of control group became pregnant by the end of breeding season (April 2010). It was concluded that melatonin implants can augment the follicle growth in lactating camels ahead of the breeding season and pregnancy can occur on mating. Fertility of treated camels during the breeding season is improved.Sommario Nel presente studio viene esaminato l'effetto di impianti di melatonina sulla crescita del follicolo in dromedari -cammelli, nei due mesi precedenti il loro periodo di * Corresponding author.E-mail address: gnpobs@gmail.com (G.N. Purohit). , 25 e 30 giorno, per il dosaggio del progesterone plasmatico e l'ecografia eseguita allo stesso tempo. Follicoli piccoli (2-3 mm) sono apparsi nella periferia delle ovaie nel 83,3% dei cammelli al 7 giorno e nel 100% dei cammelli al 14 giorno. Entro la fine della VII settimana un follicolo ovulatorio di una certa dimensione (! 1,0 cm) è stato osservato nel 83,3% dei cammelli trattati, e questi cammelli sono stati fatti accoppiare. Nel gruppo di controllo, sono apparsi piccoli follicoli alla periferia delle ovaie solo nel 66,6% dei cammelli, ma senza progresso nella crescita, fatta eccezione per un cammello (16,6%), tuttavia, la dimensione di un follicolo ovulatorio (! 10 mm) non è stata osservata in nessun cammello, entro la fine della VII settimana. Tutti i cammelli trattati hanno avuto un'ovulazione e un cammello è rimasto incinta, mentre è avvenuta la morte precoce di un embrione in un altro cammello. I cammelli non gravidi di entrambi i gruppi sono stati accoppiati durante la stagione riproduttiva. Tutti i cammelli del gruppo di trattamento e 33,33% dei cammell...

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“…Ewe age groups were chosen on the basis of previous studies on reproductive aging in this species (De Souza et al 1998, Gonzalez-Bulnes et al 2004b, Forcada et al 2007). …”

Section: Animals and Treatmentsmentioning

confidence: 99%

Effect of aging on follicular function may be relieved by exogenous gonadotropin treatment in a sheep model

Berlinguer

González-Bulnes²,

Spezzigu³

et al. 2012

Reproduction

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The current study investigated hormonal and ovarian changes during physiological reproductive aging in Sarda ewes. In a first experiment, follicular and corpus luteum dynamics were compared during an induced oestrus cycle in aged (12-14 years) and young adult ewes (4-5 years). Oestrus cycle characteristics did not differ between the two experimental groups. However, follicular function during the follicular phase showed significant alterations in aged ewes, as determined by a lack of dominance effect and by lower mean values of circulating oestradiol (E 2 ) and inhibin levels, compared with young adult ewes. In a second experiment, differences in follicle growth, hormonal milieu and oocyte quality in response to exogenous FSH administration were assessed in aged and adult ewes. No differences were recorded in ovarian response to FSH treatment between young adult and aged ewes, as evaluated by ultrasonographic data and circulating concentrations of LH, E 2 and inhibin-A. Although the total number of recovered oocytes was similar in the two age groups, the number of good quality oocytes selected for IVM was significantly lower in aged ewes compared with adult ones. Thereafter, no differences were recorded in cleavage rates, total blastocyst output, embryo developmental kinetic and quality between aged and adult groups. In conclusion, this study demonstrated that reproductive aging in sheep is associated with impaired follicle functionality and an increase in the proportion of oocytes showing morphological abnormalities. However interestingly, oocyte developmental competence in vitro and embryo cryotolerance were not affected by the aging process, when only good quality oocytes were chosen.

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Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in ewes during anestrus and the reproductive season

Cited by 22 publications

References 40 publications

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Sonographic monitoring of early follicle growth induced by melatonin implants in camels and the subsequent fertility

Effect of aging on follicular function may be relieved by exogenous gonadotropin treatment in a sheep model

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