Effects of age, smoking, drinking, exercise and estrogen use on indices of copper status in healthy adults1

Fischer, P.; L’Abbé, Mary R.; Giroux, Alexandre

doi:10.1016/s0271-5317(05)80330-6

Cited by 38 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the present study demonstrate that this is a much slower and longer process in the VLBW infant: plasma Cu levels continue to increase for the 1st year of postnatal life and beyond 3 mo, similar to term infants levels, they are higher than the normal adult values of 15.7 Jlmol/L (l00 Jlg/dL) that we see in our laboratory (33). Erythrocyte CuZnSOD is a good indicator of Cu status in adults and, in contrast with serum Cu, it is not affected by such physiologicfactors as estrogen levels (33) and responds to changes in Cu status before any differences in serum Cu or ceruloplasmin occur (8,34,35). There is little information on the use of erythrocyte CuZnSOD activity to assess Cu status in VLBW infants, and it is not known whether it rapidly increases along with plasma Cu levels.…”

Section: Discussionsupporting

confidence: 62%

Copper Status of Very Low Birth Weight Infants during the First 12 Months of Infancy

L’Abbé

Friel

1992

Pediatr Res

View full text Add to dashboard Cite

ABSTRACT. The Cu intake and status of 106 very low birth weight (VLBW) infants (birth weight 1152 ± 251 g, gestational age 29 ± 3 wk, mean ± SD) were determined approximately 1 mo before hospital discharge, at discharge (time 0), and at 3, 6, 9, and 12 mo ± 3 wk corrected for gestational age. Infants were fed either formula plus supplemental Zn/Cu (SUPPL, n = 29); formula plus placebo (PLAC, n = 26); or a low birth weight formula (LBWF, n = 26) or were breast-fed (BRMLK, n = 25).Plasma Cu levels in the formula-fed infants increased significantly at each time period with no significant differences between feeding groups. Hair Cu was significantly higher in the SUPPL group compared to the PLAC, LBWF, and BRMLK groups at 3 and 6 mo. Erythrocyte Cu,Zn-superoxide dismutase (CuZnSOD) activity was lowest in the PLAC group. Cu intake was positively correlated with both hair Cu (r = 0.291, p < 0.0001) and erythrocyte CuZnSOD activity (r = 0.281, p < 0.001) but not with plasma Cu. An increasing number of formula-fed infants had very low CuZnSOD activity (less than 2 SD below mean) with increasing age (n = 1,2,8, 11, and 13 infants at times 0, 3, 6, 9, and 12 mo, respectively). At 12 mo, approximately one third of the formula-fed VLBW infants in this study had low Cu status as assessed by CuZnSOD activity. Infants with the lowest CuZnSOD activity were those with the largest weight gains from 0 to 6 mo and were observed in all formula-fed groups. Thus, these data suggest that in formula-fed infants erythrocyte CuZnSOD activity is a more appropriate indicator of Cu status in the VLBW infant than plasma Cu levels and that the fastest growing VLBW infants may be at risk for Cu deficiency.

show abstract

Section: Discussionsupporting

confidence: 62%

Copper Status of Very Low Birth Weight Infants during the First 12 Months of Infancy

L’Abbé

Friel

1992

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…This result is in accordance with what has been reported in literatures. Serum copper is normally higher in women than in men [15,16]. The amount of orally ingested Cu absorbed from the intestine is variable.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Antioxidants (Zn, Cu, Se) in Healthy Volunteers Living in Tehran

Farzin

Moassesi

Sajadi

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

Zinc (Zn), copper (Cu), and selenium (Se) are well-known as essential trace elements. These elements attract a great interest, not only in the scientific world, but also in the public option. The aim of this study was to evaluate the serum Zn, Cu, and Se levels in healthy volunteers (60 females and 55 males) living in Tehran. The age (6-62 years) and sex of the subjects, as well as drug and tobacco consumption, were registered. The concentrations of these elements were determined by atomic absorption spectrometry. The serum levels of Zn, Cu, and Se in the normal population of Tehran was 0.89 +/- 0.16 mg/L, 0.95 +/- 0.20 mg/L, and 99.10 +/- 21.78 microg/L, respectively. There was no significant gender-related difference in serum Zn concentration (p < 0.15). However, a significant difference (p < 0.05) in both Cu and Se levels was observed between males and females.

show abstract

“…Coupled with the information from diet records, there is reason to suspect that some athletes could be deficient in zinc. Fischer et al (1990) examined copper status of 384 healthy adults, the subjects were separated into four activity levels ranging from sedentary to vigorous. There was no significant difference between groups for serum copper, ceruloplasmin activity, or Cu,Znsuperoxide dismutase activity .…”

Section: Zinc Statusmentioning

confidence: 99%

Minerals: Exercise performance and supplementation in athletes*

Clarkson

1991

Journal of Sports Sciences

View full text Add to dashboard Cite

This paper examines whether mineral supplements are necessary for athletes, and whether these supplements will enhance performance. Macrominerals (calcium, magnesium, and phosphorus) and trace minerals (zinc, copper, selenium, chromium, and iron) are described. Calcium supplements are important for the health of bones. Athletes tend to have enhanced calcium status as assessed by bone mineral density, with the notable exception of female amenorrhoeic athletes. Magnesium status is adequate for most athletes, and there is no evidence that magnesium supplements can enhance performance. Phosphorus status is adequate for athletes. Phosphorus supplementation over an extended period of time can result in lowered blood calcium, however, some studies have shown that acute 'phosphate loading' will enhance performance. Athletes may have a zinc deficiency induced by poor diet and loss of zinc in sweat and urine. Limited data exist on the relationship of performance and zinc status. Widespread deficiencies in copper have not been documented, and there are no data to suggest that copper supplementation will enhance performance. There is no reason to suspect a selenium deficiency in athletes. The relationship between selenium status and performance has not been established, but selenium may play a role as an antioxidant. Because of the low intakes of chromium for the general population, there is a possibility that athletes may be deficient. Exercise may create a loss in chromium because of increased excretion into the urine. Many athletes, particularly female, are iron depleted, but true iron deficiencies are rare. Iron depletion does not affect exercise performance but iron deficiency anaemia does. Iron supplements have not been shown to enhance performance except where iron deficiency anaemia exists. In conclusion, poor diets are perhaps the main reason for any mineral deficiencies found in athletes, although in certain cases exercise could contribute to the deficiency. Mineral supplementation may be important to ensure good health, but few studies have definitively documented any beneficial effect of mineral supplementation on performance.

show abstract

Effects of age, smoking, drinking, exercise and estrogen use on indices of copper status in healthy adults1

Cited by 38 publications

References 16 publications

Copper Status of Very Low Birth Weight Infants during the First 12 Months of Infancy

Copper Status of Very Low Birth Weight Infants during the First 12 Months of Infancy

Serum Levels of Antioxidants (Zn, Cu, Se) in Healthy Volunteers Living in Tehran

Minerals: Exercise performance and supplementation in athletes*

Contact Info

Product

Resources

About