Effects of age, sex and pathological type on the risk of multiple polyps: A Chinese teaching hospital study

Abstract

Objectives The lack of risk profile data on changes in multiple polyps identified by a colonoscopy constrains the creation of evidence‐based guidelines. Our study aimed to investigate the relationship between size, location and histology of multiple polyps and patients’ characteristics in a large teaching hospital‐based Chinese population. Methods We conducted a large, case‐control, retrospective analysis on polyps obtained from 8308 patients who presented at the Digestive Endoscopy Center, Changhai Hospital (Shanghai, China) from January 2013 to August 2015. In total 10572 polyps were analyzed, with risk factors extrapolated through chart reviews of patients’ electronic medical records. Results Single polyps were identified in 6843 (82.4%) patients while multiple polyps were found in 1465 (17.6%). A multivariate analysis indicated that men were more likely than women to have multiple polyps (P < 0.001). Compared with the single polyps group, the numbers of patients with multiple polyps increased significantly with age (P < 0.001). Multiple small (6‐9 mm) non‐advanced adenomas were more likely to be found than were diminutive (<5 mm) non‐advanced adenomas (P < 0.001). While most advanced and non‐advanced adenomas were diagnosed in patients with single adenomas (55.9% and 65.6%, respectively), advanced adenomas were more likely than non‐advanced adenomas to be in multiples (P < 0.001). Conclusions Our data indicate that particular features of colorectal polyps, such as their large size, advanced histology, together with patients’ characteristics, including their sex and age, are risk factors associated with multiple polyps during diagnosis, screening and surveillance.

Risk factors and correlation of colorectal polyps with type 2 diabetes mellitus

“…Numerous studies have confirmed that the incidence of colorectal polyps increases with age (5). The risk of colorectal polyps increases by 1.03 times with a 1-year increase in age (28). Lieberman et al reported that the colonoscopy results of 327,785 patients in the United States showed that the incidence rate of colorectal polyps increased with age, and the incidence rate in males was higher than that in females (29).…”

Establishment and evaluation of a nomogram predicting risks of missed diagnoses of colorectal polyps

“…Interestingly, our study showed that patients with ≥ 2 polyps larger than 6 mm in diameter were 2.96 times more likely to miss polyps than those with less than two polyps larger than 6 mm in diameter. A study found that patients with small adenomas (6–9 mm) are more likely to develop multiple adenomas than those with small adenomas (< 5 mm) [ 11 ]. Kim et al [ 7 ] also found that patients with multiple adenomas had a higher risk of missed diagnoses of adenomas.…”

“…Polyp size was measured using the opening diameter of the biopsy forceps (6 mm). The cut-off value for the number of polyps was set as two since ≥ 2 polyps are commonly referred to as multiple polyps [ 11 ].…”

Establishment and Evaluation of a Nomogram Predicting Risks of Missed Diagnoses of Colorectal Polyps

“…A higher number of polyps sized ≥ 6 mm is associated with a higher risk of a missed diagnosis of polyps. It has been reported [11] that patients with small adenomas (6−9 mm) are more likely to develop multiple adenomas than those with small adenomas (< 5 mm). Kim et al[8] reported that patients with multiple adenomas had a higher risk of missed diagnoses of adenomas.…”

“…Polyp size was measured using the opening diameter of the biopsy forceps (6 mm). The cut-off value for the number of polyps was set as 2 since ≥ 2 polyps are commonly referred to as multiple polyps [11].…”