Effects of Age on the Gastroesophageal Junction, Esophageal Motility, and Reflux Disease

Lee, Jacqueline; Anggiansah, Angela; Anggiansah, Roy; Young, A. E.; Wong, Terry; Fox, Mark

doi:10.1016/j.cgh.2007.08.011

Cited by 170 publications

(133 citation statements)

References 35 publications

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“…Increased GERD severity due to degradation of the gastroesophageal junction and impaired esophageal clearance was found in the elderly [26] . Yet, age as a factor contributing to LPR seldom has been mentioned before.…”

Section: Discussionmentioning

confidence: 99%

Laryngopharyngeal reflux in patients with reflux esophagitis

Lai

Wang²,

Lin³

2008

WJG

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Section: Discussionmentioning

confidence: 99%

Laryngopharyngeal reflux in patients with reflux esophagitis

Lai

Wang²,

Lin³

2008

WJG

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“…14 The Bravo system provides the means to obtain definitive diagnosis of GERD in this cohort. This study demonstrates that the Bravo technique is well tolerated and that pH measurement has a high diagnostic yield in these individuals.…”

Section: Discussionmentioning

confidence: 99%

Patient acceptance and clinical impact of Bravo monitoring in patients with previous failed catheter‐based studies

Sweis

Fox

Anggiansah

et al. 2009

Aliment Pharmacol Ther

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SUMMARY BackgroundStandard pH monitoring is performed over 24 h with a naso-oesophageal catheter (C-pH). Limitations include naso-pharyngeal discomfort, nausea and social embarrassment resulting in reduced reflux-provoking activities. Recently a catheter-free pH-monitoring technique has become available. The tolerability and diagnostic yield of this system in patients who failed standard monitoring remain unknown.

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“…This could be an important clinical issue because the persistence of elevated gastric acid secretion could lead to more prevalent acid-related diseases such as GERD with advancing age through agingrelated motility disorders of the esophagus (Lee et al 2007). On the other hand, changes in individual dietary patterns with aging might alleviate gastric acid secretion levels.…”

Section: Discussionmentioning

confidence: 99%

A Chronological Increase in Gastric Acid Secretion from 1995 to 2014 in Young Japanese Healthy Volunteers under the Age of 40 Years Old

Iijima

Koike

Abe

et al. 2016

Tohoku J. Exp. Med.

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Gastric acid secretion levels are an important determinant of the manifestation of acid-related upper GI diseases such as gastroesophageal reflux disease. We recently reported that gastric acid secretion levels did not change from the 1990s to 2010s in H. pylori-negative asymptomatic Japanese outpatients with a mean age of 63 years old. However, because young people have a quite different lifestyle, including dietary pattern, from elderly people in Japan, it is worth investigating any chronologic changes in gastric acid secretion in younger generations. The aim of this analysis is to investigate the potential changes in gastric acid secretion from 1995 to 2014 in young Japanese healthy volunteers. Eighty-eight young Japanese healthy volunteers under the age of 40 with a mean age of 26 were extracted from a database accumulated from 1995 to 2014 for the present analysis. Their gastrin-stimulated gastric acid level was determined with the endoscopic gastrin test. In 76 H. pylori-negative subjects, gastric acid secretion levels showed a significant positive correlation with the calendar year when the test was performed (r = 0.27, p < 0.01). A similar trend was observed in 12 H. pylori-positive subjects. A chronological 5-year time period showed a significant positive association with gastric acid secretion in univariate and multivariate analyses (p < 0.01 and p = 0.01, respectively). Gastric acid secretion levels have been increasing in young Japanese healthy volunteers during the last 20 years. We need to monitor future trends in the prevalence of acid-related diseases such as gastro-esophageal reflux disease in Japan.

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Effects of Age on the Gastroesophageal Junction, Esophageal Motility, and Reflux Disease

Cited by 170 publications

References 35 publications

Laryngopharyngeal reflux in patients with reflux esophagitis

Laryngopharyngeal reflux in patients with reflux esophagitis

Patient acceptance and clinical impact of Bravo monitoring in patients with previous failed catheter‐based studies

A Chronological Increase in Gastric Acid Secretion from 1995 to 2014 in Young Japanese Healthy Volunteers under the Age of 40 Years Old

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