Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders

Kao, Yu Hsun; Liu, Yia-Ping

doi:10.1186/1471-244x-10-63

Cited by 76 publications

(53 citation statements)

References 52 publications

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“…By comparison, Oie et al [74] found a mean GAS score of 47.7 in their EOS group containing 15 patients assessed when they were clinically stable on antipsychotic medication and followed up for 13 years. Moreover, Kao et al [75] found a mean GAF score of 47 in 19 EOS patients after 1 year follow-up, and Gochman et al [76] found a mean CGAS score of 43.6 after at least 8 years of follow-up. In the single intervention study included in the current review, the mean GAF score was 35 in the intervention group and 24 in the control group [55].…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the long-term outcome of early onset schizophrenia

2012

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BackgroundThe current review analyzes the long-term outcome and prognosis of early onset schizophrenia based on previously published studies in 1980.MethodsA systematic search of articles published in the English-language literature after 1980 identified a total of 21 studies, which included 716 patients who were either suffering from early onset schizophrenia (EOS) or both EOS and other psychotic disorders (MIX). The authors of the current review scored the outcome as either “good,” “moderate,” or “poor.” The mean age of onset in these studies was <18 years.ResultsIn general, the outcome in studies with EOS is worse than the outcome in MIX studies. Only 15.4% of the patients in EOS studies versus 19.6% of the patients in MIX studies experienced a “good” outcome. In contrast, 24.5% of the patients in EOS studies versus 33.6% in MIX studies experienced a “moderate” outcome, and 60.1% in EOS studies versus 46.8% in MIX studies experienced a “poor” outcome. The authors identified various significant effects on outcome. In EOS, the findings were significantly affected by sample attrition, indicating that in studies with a high dropout rate, fewer patients experienced a “moderate” outcome, and more patients experienced a “poor” outcome; however, the effect sizes were small. Furthermore, the effects were also small and more favourable for specific functioning measures, as opposed to more global measures, small to moderate in terms of worse outcomes for follow-up periods >10 years, small to moderate for more unfavourable outcomes in males, and small to large for worse outcomes in studies including patients diagnosed before 1970.ConclusionsIn contrast to the adult manifestation, the early manifestation of schizophrenia in childhood and adolescence still carries a particularly poor prognosis. According to these aggregated data analyses, longer follow-up periods, male sex, and patients having been diagnosed before 1970 contribute predominantly to the rather poor course of EOS.

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Section: Discussionmentioning

confidence: 99%

A systematic review of the long-term outcome of early onset schizophrenia

2012

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“…Earlier onset age was associated with a higher severity of idiosyncratic disturbances, which is consistent with a large body of evidence linking early onset to an overall more severe form of psychosis, including higher levels of TD (Kao et al, 2010). Interestingly, earlier onset has been found to characterize familial psychosis, a finding that was replicated in the current data (Husted, Greenwood, & Bassett, 2006;Kendler & MacLean, 1990).…”

Section: Summary Of Resultssupporting

confidence: 89%

Exploring a multifactorial, clinical model of thought disorder : application of a dimensional, transdiagnostic approach.

Hart¹

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“…En varios estudios se ha reportado que las mujeres presentan inicio más tardío y menor gravedad de la enfermedad (6)(7)(8)(9). Además, en hombres se ha encontrado un peor funcionamiento premórbido, más síntomas negativos y cognoscitivos, así como una mayor frecuencia de anormalidades cerebrales estructurales o trastornos neuropsicológicos (10).…”

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Edad de inicio de los síntomas y sexo en pacientes con trastorno del espectro esquizofrénico

Sánchez¹,

Téllez²,

Jaramillo³

2012

biomedica

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Edad de inicio de los síntomas y sexo en pacientes con trastorno del espectro esquizofrénicoIntroducción. Existe controversia sobre la posibilidad de que la edad de inicio de la esquizofrenia y de algunas características clínicas del trastorno, sean diferentes entre hombres y mujeres. Objetivo. Evaluar la relación entre sexo, edad de inicio y síntomas negativos en pacientes con trastornos del espectro esquizofrénico. Materiales y métodos. Se evaluaron 225 pacientes para medir la edad de inicio de los síntomas y el puntaje en la escala SANS (Scale for the Assessment of Negative Symptoms). Se usaron estimadores de densidad kernel para evaluar las características de la edad de inicio. Se estimaron los parámetros de distribuciones mezcladas usando algoritmos de máxima verosimilitud. La relación síntomas negativosedad de inicio se evaluó usando regresión múltiple.Resultados. Hubo diferencia significativa en la edad de inicio según el sexo (24,5 años en hombres Vs. 27,5 años en mujeres). Se encontró asociación entre sexo y comienzo temprano de síntomas, siendo este último más frecuente en hombres. Los estimadores de densidad para la edad de inicio sugieren un modelo mezclado con tres componentes, con los siguientes parámetros: m1=21,55, sd1=5,25; m2=29,54, sd2=7,22; y m3=40,01, sd3=3,98. Al tener en cuenta el sexo, se aíslan dos estructuras bimodales: la de hombres tiene la menor media de edad de inicio (18,02 años) mientras que la de media más alta corresponde a las mujeres (41,03 años). Los coeficientes de regresión sugieren incremento en los síntomas negativos a medida que aumenta el tiempo con enfermedad. Conclusión. Nuestros resultados apoyan la hipótesis de que existe relación entre la edad de inicio de los síntomas, el sexo y las características clínicas, en pacientes con trastornos del espectro esquizofrénico, lo que demuestra que los hombres tienen un inicio más temprano y un curso de la enfermedad con mayor deterioro.Palabras clave: esquizofrenia y trastornos con características psicóticas/epidemiología, edad de inicio, distribución por edad y sexo, incidencia, prevalencia, resultado del tratamiento, modelos estadísticos. Age of onset symptoms and gender in schizophrenic spectrum disordersIntroduction. Some controversy exists concerning whether the onset of schizophrenia and some clinical characteristics of the disorder are different between males and females. Objective. The relationship between sex, age at onset and negative symptoms was evaluated in patients with schizophrenic spectrum disorders. Materials and methods. A sample of 225 patients (89 women and 136 men) were diagnosed for schizophrenia between 2008 and 2009. Each was compared for age at onset of symptoms and SANS score (Scale for the Assessment of Negative Symptoms). Kernel density estimators were used to evaluate characteristics of age of onset with respect to gender. Parameters of the mixed distributions were estimated via maximum-likelihood algorithms. Relationships between negative symptoms score and age of onset were evaluated using multi...

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Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders

Cited by 76 publications

References 52 publications

A systematic review of the long-term outcome of early onset schizophrenia

A systematic review of the long-term outcome of early onset schizophrenia

Exploring a multifactorial, clinical model of thought disorder : application of a dimensional, transdiagnostic approach.

Edad de inicio de los síntomas y sexo en pacientes con trastorno del espectro esquizofrénico

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