Effects of age, gender and metabolic factors on endothelium‐dependent vasodilation: a population‐based study

Sarabi, Mahziar; Millgård, Jonas; Lind, Lars

doi:10.1046/j.1365-2796.1999.00542.x

Cited by 45 publications

(33 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A liberation of certain polyunsaturated fatty acids might also generate prostanoid-derived endothelium-generated constricting factors, such as thromboxane A2. Furthermore, also a modest rise in circulating glucose levels during MAT might attenuate EDV, as been shown in laboratory studies ) and in a population study (Sarabi et al 1999).…”

Section: Discussionmentioning

confidence: 57%

Mental Stress Impairs Endothelial Vasodilatory Function by a Beta-Adrenergic Mechanism

et al. 2007

Self Cite

View full text Add to dashboard Cite

Mental stress has been shown to impair endothelium-dependent vasodilation (EDV) in the human forearm. The aim of this study was to investigate if this response could be blunted by local infusions of beta-blockade (propranolol), alpha-blockade (phentolamine), or neurogenic blockade. Thirty-one young healthy volunteers underwent forearm blood flow (FBF) measurements, using venous occlusion plethysmography, during local intra-arterial infusions of metacholine (MCh; inducing EDV) and sodium nitroprussid (SNP; inducing endothelial-independent vasodilation [EIDV]), respectively. These measurements were repeated during a 5-min mental arithmetic stress test without (n = 8) or with concomitant local infusion of propranolol (n = 7) or phentolamine (n = 8) in the forearm or during axillary plexus blockade (n = 8). An index of endothelial vasodilatory function (EFI) was calculated as the EDV to EIDV ratio. Mental stress impaired EDV significantly (p < .05), and as a result, EFI was significantly reduced (p = .02). This effect on EFI could be blocked by propranolol and neurogenic blockade but not by phentolamine (p < .05). Thus, impairment of endothelial vasodilatory function induced by mental stress could be blocked by beta-adrenergic, but not alpha-adrenergic, receptor blockade.

show abstract

Section: Discussionmentioning

confidence: 57%

Mental Stress Impairs Endothelial Vasodilatory Function by a Beta-Adrenergic Mechanism

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been suggested that the increase in wall thickness with ageing is related to elevation in sympathetic outflow in the older individuals . Peak reactive hyperemic blood flow, an index of remodelling in resistance vessels in humans, is typically smaller in older individuals and independent of gender (Takeshita and Mark 1980;Sinoway et al 1986;Silber and Sinoway 1990;Silber et al 1991;Sarabi et al 1999). This suggests an age-dependent decrease in collective crosssectional area of peripheral resistance artery vascular bed and may infer the existence of some concentric arterial remodelling at this level of the vasculature.…”

Section: Impact Of Ageing On Vascular Structurementioning

confidence: 99%

Cardiovascular function and the veteran athlete

et al. 2010

View full text Add to dashboard Cite

The cardiovascular benefits of exercise are well known. In contrast, the impact of lifelong endurance exercise is less well understood. Long-term high-intensity endurance exercise is associated with changes in cardiac morphology together with electrocardiographic alterations that are believed to be physiologic in nature. Recent data however has suggested a number of deleterious adaptive changes in cardiac structure, function and electrical activity, together with peripheral and cerebral vascular structure and function. This review serves to detail knowledge in relation to; (1) Cardiac structure and function in veteran endurance athletes focusing on the differentiation of physiological and pathological changes in cardiac remodelling; (2) Cardiac electrical activity and the veteran endurance athlete with attention to arrhythmias, the substrate for arrhythmia generation and the clinical significance of such arrhythmias; (3) Peripheral and cerebral vascular structure and function in ageing and endurance-trained individuals; and (4) directions for future research.

show abstract

“…Sex differences in FMD have been reported concomitantly with a greater postcuff hyperemia in premenopausal women compared with age-matched men (27,51). This effect has been explained by the positive influence of endogenous estrogens on the availability of NO (16), the principal vasodilator in shearmediated vasodilation (31).…”

Section: A Hormonal Milieu Effect On Flow-mediated Dilation?mentioning

confidence: 99%

Sex and limb-specific ischemic reperfusion and vascular reactivity

Nishiyama

Wray

Richardson

2008

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Nishiyama SK, Wray DW, Richardson RS. Sex and limbspecific ischemic reperfusion and vascular reactivity. Am J Physiol Heart Circ Physiol 295: H1100 -H1108, 2008. First published July 11, 2008 doi:10.1152/ajpheart.00318.2008.-With little known regarding sex and limb heterogeneity, we investigated vascular reactivity and ischemic reperfusion (IR) in the upper and lower extremities of 15 healthy men (26 Ϯ 2 yr) and women (23 Ϯ 1 yr). Doppler ultrasound was used to evaluate IR and flow-mediated dilation (FMD) after suprasystolic cuff occlusion in both the arm [brachial artery (BA)] and the leg [popliteal artery (PA)]. Cumulative IR [area under the curve (AUC)], normalized for muscle mass, revealed no sexrelated differences in either limb (forearm: men 38 Ϯ 3 and women 44 Ϯ 4 ml/100 g; lower leg: men 12 Ϯ 2 and women 14 Ϯ 2 ml/100 g), while both groups revealed a greater IR per unit of arm muscle mass (AUC) compared with the lower leg (P Ͻ 0. vasodilation; vascular function; hyperemia; females THE INCIDENCE OF CARDIOVASCULAR disease differs significantly between men and women. This is thought to be predominantly due to sex-specific differences in risk factors and the hormonal milieu. Indeed, epidemiologic studies have revealed that atherosclerosis, hypertension, and peripheral vascular and coronary artery diseases occur with greater prevalence in men and in postmenopausal women compared with premenopausal women (4, 23, 26), while clinical assessments of endotheliumdependent peripheral artery vasomotion, flow-mediated vasodilation (FMD), in healthy populations suggest that vascular function is superior in premenopausal women compared with their postmenopausal counterparts and with men (27, 40, 52). En masse, these studies have implicated estrogen as both a prostaglandin promoter and an antioxidant, protecting nitric oxide (NO) from degradation and facilitating increased vasomotion (29, 39). Thus current knowledge suggests that female sex hormones, such as estrogen, have positive vascular effects, whereas their absence could be related to vascular dysfunction and subsequent atherogenic disease states. However, in studies assessing FMD, when the initial value of arterial diameter is taken into consideration, vasodilation appears similar between males and females (18). This suggests that some of the documented sex differences in vascular reactivity could be the consequence of a mathematical bias rather than the beneficial effects of the female hormonal milieu.There is an emerging belief that vascular function in the arms and legs of humans is not uniform, but to our knowledge there is a relative paucity of studies that examine limb-specific sex differences in vascular reactivity. Most studies of arterial FMD have been conducted in the brachial artery (BA), but the extent to which this can index systemic vascular function has recently been questioned (35,54). Humans, as upright bipeds, are regularly subjected to large hydrostatic and transmural forces in the legs that appear to contribute to differential vasoreactivity (...

show abstract

Effects of age, gender and metabolic factors on endothelium‐dependent vasodilation: a population‐based study

Cited by 45 publications

References 47 publications

Mental Stress Impairs Endothelial Vasodilatory Function by a Beta-Adrenergic Mechanism

Mental Stress Impairs Endothelial Vasodilatory Function by a Beta-Adrenergic Mechanism

Cardiovascular function and the veteran athlete

Sex and limb-specific ischemic reperfusion and vascular reactivity

Contact Info

Product

Resources

About