Effects of age and sex on clinical high-risk for psychosis in the community

Schultze‐Lutter, Frauke; Schimmelmann, Benno G.; Flückiger, Rahel; Michel, Chantal

doi:10.5498/wjp.v10.i5.101

Cited by 18 publications

(36 citation statements)

References 79 publications

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“…The only exception was disorganized communication at APS-level for that, in interaction with age, no stable association with functional deficits was revealed. Non-psychotic mental disorders, however, were mainly predicted independently by female sex and presence of APS (29). Again, disorganized communication was an exception in that it predicted mental disorder by its interaction with age rather than its sole presence.…”

Section: Introductionmentioning

confidence: 76%

“…Again, disorganized communication was an exception in that it predicted mental disorder by its interaction with age rather than its sole presence. In doing so, participants without disorganized communication were commonly younger than those with it; this age effect being more pronounced in those with mental disorder (29).…”

Section: Introductionmentioning

confidence: 89%

“…Again, this evidence has mainly accumulated for APS and BLIPS (13,14,(21)(22)(23)(24)(25)(26)(27)(28), in doing so indicating an age threshold around the age of 16 below which these symptoms are more frequent, but less clinically relevant in terms of their association with functional deficits and/or nonpsychotic mental disorder, and less psychosis-predictive (21-23, 28, 29). In doing so, the interaction of APS with age played a particular role in predicting psychosocial functioning, with APS being increasingly associated with functional deficits with advancing age in the community (29). The only exception was disorganized communication at APS-level for that, in interaction with age, no stable association with functional deficits was revealed.…”

Section: Introductionmentioning

confidence: 95%

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Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

et al. 2020

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Section: Introductionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 95%

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Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

et al. 2020

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“…As discussed in the last paragraph, the telephone assessment may cause the missed diagnosis of CHR, which was a limitation of this study, whereas, it saved a lot of human resources in the process of CHR screening, indeed, particularly in a large general population. It is worth mentioning that the telephone assessment employed in this study was not a semi-structured or structured interview that can be seen in other studies, although we also use SIPS as the assessing instrument [31,53,54]. In the present study, it only required the researchers to ask questions following the subscale for positive symptoms, and rate the severity for each domain according to the subjective reports from the participants.…”

Section: Discussionmentioning

confidence: 99%

Screening of the College Students at Clinical High Risk for Psychosis in China: A Multicenter Epidemiological Study

Long

Liu

et al. 2020

Preprint

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Background To investigate a 3-stage screening procedure and explore the clinical features of subjects at Clinical High Risk (CHR) for psychosis in a representative sample of Chinese college students. Methods An epidemiological survey of the prevalence of CHR syndrome in Chinese college students that was selected by stratified random sampling from Shanghai, Nanjing and Nanchang cities was done followed a 3-stage procedure. Participants was initially screened with the Prodromal Questionnaire-brief version (PQ-B), and whose distress score of PQ-B exceeded 24 would be invited to a telephone assessment using the subscale for positive symptoms of the Scale of Prodromal Symptoms (SOPS)/Structured Interview for Prodromal Syndromes (SIPS). Lastly, participants who scored 3 or higher in any item of the subscale would be administered with the SIPS interview conducted by trained researchers to confirm the diagnosis of CHR syndrome. Results 23 063 college students completed the survey during September 2017 to October 2018. 72 students were diagnosed as CHR subjects, and the detection rate in the total sample was 0.3%. The peak age range for the first diagnosis of CHR was 17 to 20 years. 13 and 46 were set as the cut-off points of PQ-B total score and distress score to balance the greatest sensitivity and specificity. Binary logistic regression revealed that 5 items in PQ-B showed significant distinction for detecting CHR subjects. Conclusions The 3-stage screening method can be utilized in the detection of CHR subjects for psychosis in general population, during which delusional ideas, perceptual abnormalities and suspiciousness deserve great attention.

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“…Gender-specific symptoms (depression and anorexia/bulimia in women; attention deficits and substance abuse in men) have been reported in patients during the at-risk for psychosis stage that often precedes schizophrenia [25,26]. Comparing men and women during the early years of illness (the first five years), Comacchio et al [27] found that men show more negative symptoms and that women more frequently than men report comorbid depression.…”

Section: Gender-associated Symptoms In Schizophreniamentioning

confidence: 99%

Schizophrenia Psychosis in Women

Seeman

2020

Women

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A first step towards personalized medicine is to consider whether, for some disorders, the safest and most effective treatment of women needs to differ from standard guideline recommendations developed on the basis of clinical trials conducted, for the most part, in men. A second step is to consider how women’s reproductive stages—pre-pubertal years, menstrual phases, pregnancy trimesters, lactation and postpartum periods, menopausal and postmenopausal/aging status—affect the optimal choice of treatment. This review focuses on these two steps in the treatment of psychosis, specifically schizophrenia. It discusses genetics, precursors and symptoms of schizophrenia, reproductive and associated ethical issues, antipsychotic drug response and adverse effects, substance abuse, victimization and perpetration of violence, and issues of immigration and of co-morbidity. The conclusions, while often based on clinical experience and theoretical considerations rather than strictly on the evidence of randomized controlled trials, are that clinical recommendations need to consider clinical and role differences that exist between men and women and make appropriate correction for age and reproductive status.

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Effects of age and sex on clinical high-risk for psychosis in the community

Cited by 18 publications

References 79 publications

Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

Screening of the College Students at Clinical High Risk for Psychosis in China: A Multicenter Epidemiological Study

Schizophrenia Psychosis in Women

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