Effects of age and sex on osteocalcin and bone-specific alkaline phosphatase—reference intervals and confounders for two bone formation markers

Diemar, Sarah Seberg; Møllehave, Line Tang; Quardon, N.; Lylloff, Louise; Thuesen, Betina Heinsbæk; Linneberg, Allan; Jørgensen, Niklas Rye

doi:10.1007/s11657-020-00715-6

Cited by 28 publications

(24 citation statements)

References 44 publications

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“…Decrease with age (Mera et al, 2016a;Diemar et al, 2020). Negative association with BMD (Kim et al, 2010;Ling et al, 2016).…”

Section: Age-related Bone-muscle Crosstalkmentioning

confidence: 99%

“…Studies reported positive association between serum OCN and testosterone, meanwhile low OCN is related to impaired brain cognition and microstructure (Puig et al, 2016;Zhong et al, 2016). Therefore, although the results regarding OCN and age are controversial, we prefer the theory suggesting plasma OCN levels decrease with age (Mera et al, 2016a;Diemar et al, 2020). Nevertheless, many cross-sectional investigations revealed that OCN is negatively associated with BMD (Kim et al, 2010;Ling et al, 2016).…”

Section: Osteocalcin In Bone-muscle Crosstalk During Agingmentioning

confidence: 99%

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Bone and Muscle Crosstalk in Aging

Hou

et al. 2020

Front. Cell Dev. Biol.

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Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.

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“…Decrease with age (Mera et al, 2016a;Diemar et al, 2020). Negative association with BMD (Kim et al, 2010;Ling et al, 2016).…”

Section: Age-related Bone-muscle Crosstalkmentioning

confidence: 99%

Section: Osteocalcin In Bone-muscle Crosstalk During Agingmentioning

confidence: 99%

Bone and Muscle Crosstalk in Aging

Hou

et al. 2020

Front. Cell Dev. Biol.

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“…As in T2DM bone turnover marker levels are decreased compared to nondiabetic subjects, it cannot be excluded that associations between osteocalcin and glycemic markers could be driven by the presence of diabetes or not in such studies. Low osteocalcin levels are linked with impaired glucose metabolism in men and premenopausal women [ 10 ]. In particular, serum osteocalcin concentrations seem to have a negative and independent relation with HbA1c levels in men and women aged < 50 years, but not in postmenopausal women [ 11 , 12 , 13 ].…”

Section: How Bone Active Therapies Affect Glucose Metabolismmentioning

confidence: 99%

The Impact of Antiosteoporotic Drugs on Glucose Metabolism and Fracture Risk in Diabetes: Good or Bad News?

Anastasilakis

Tsourdi

Tabacco

et al. 2021

JCM

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Osteoporosis and diabetes mellitus represent global health problems due to their high, and increasing with aging, prevalence in the general population. Osteoporosis can be successfully treated with both antiresorptive and anabolic drugs. While these drugs are clearly effective in reducing the risk of fracture in patients with postmenopausal and male osteoporosis, it is still unclear whether they may have the same efficacy in patients with diabetic osteopathy. Furthermore, as bone-derived cytokines (osteokines) are able to influence glucose metabolism, it is conceivable that antiosteoporotic drugs may have an effect on glycemic control through their modulation of bone turnover that affects the osteokines’ release. These aspects are addressed in this narrative review by means of an unrestricted computerized literature search in the PubMed database. Our findings indicate a balance between good and bad news. Active bone therapies and their modulation of bone turnover do not appear to play a clinically significant role in glucose metabolism in humans. Moreover, there are insufficient data to clarify whether there are any differences in the efficacy of antiosteoporotic drugs on fracture incidence between diabetic and nondiabetic patients with osteoporosis. Although more studies are required for stronger recommendations to be issued, bisphosphonates appear to be the first-line drug for treatment of osteoporosis in diabetic patients, while denosumab seems preferable for older patients, particularly for those with impaired renal function, and osteoanabolic agents should be reserved for patients with more severe forms of osteoporosis.

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“…Accurately, the level of OC in serum is influenced by many factors. Serum OC levels decreased with increasing age and increased with female sex in a general adult Danish population (31). PTH can promote osteoblasts to synthesize and secrete OC.…”

Section: Discussionmentioning

confidence: 86%

Osteocalcin and Abdominal Aortic Calcification in Hemodialysis Patients: An Observational Cross-Sectional Study

et al. 2021

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ObjectivesTo investigate the serum level of osteocalcin (OC), also known as bone Gla protein, in maintenance hemodialysis (MHD) patients and its correlation with abdominal aortic calcification (AAC).MethodsFrom July 2017 to February 2020, we enrolled 108 adult MHD patients. Routine fasting blood laboratory tests were performed before the start of the second hemodialysis in a week. Abdominal aortic calcification score (AACs) was assessed within 1 month. Pearson correlation and Logistic regression were used to analyze the data.ResultsThe OC level was 231.56 (25.92,361.33) ng/ml, elevating significantly in this group of MHD patients. It had a positive correlation with serum phosphorus (r = 0.511, P = 0.001), intact parathyroid hormone(iPTH) (r = 0.594, P = 0.0001), fibroblast growth factor 23(FGF23) (r = 0.485, P = 0.003) and a negative correlation with age(r = -0.356, P = 0.039). Based on the AACs, patients were divided into two groups. Serum OC level were higher in patients with AACs≥5 (p=0.032). A multiple logistics regression analysis revealed that age (odds ratio [OR]1.14, P=0.005) and OC(OR=1.10, P=0.008)were risk factors for high AACs(≥5).ConclusionThe study implicated that OC elevated significantly in this group of MHD patients.OC is positively correlated with phosphorus, iPTH, FGF23, and a negative correlation with age. OC was a risk factor for vascular calcification in this study, but this study did not classify osteocalcin as c-OC and unOC. Whether unOC is associated more directly with vascular calcification requires further study.

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Effects of age and sex on osteocalcin and bone-specific alkaline phosphatase—reference intervals and confounders for two bone formation markers

Cited by 28 publications

References 44 publications

Bone and Muscle Crosstalk in Aging

Bone and Muscle Crosstalk in Aging

The Impact of Antiosteoporotic Drugs on Glucose Metabolism and Fracture Risk in Diabetes: Good or Bad News?

Osteocalcin and Abdominal Aortic Calcification in Hemodialysis Patients: An Observational Cross-Sectional Study

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