Effects of age and sex on bone density in the rhesus monkey

Pope, N.S.; Gould, Kenneth G.; Anderson, D.C.; Mann, David R.

doi:10.1016/8756-3282(89)90007-0

Cited by 69 publications

(43 citation statements)

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“…Only a few studies have shown that macaques undergo a natural pattern of change in bone mineralization that parallels the changes seen in humans. Previous studies suggest that bone mass peaks at 10-14 years of age in rhesus monkeys [3,28] and around 9 years of age in cynomolgus monkeys [18]. Precise determination of this peak will be important in the study of diseases associated with bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

et al. 2000

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Age-related changes in bone mineral content and bone biomarkers were assessed over the complete lifespan of female cynomolgus monkeys. The bone mass of the lumbar spine increased linearly from birth to about 2.5 years of age, and this increase gradually slowed thereafter until a peak bone mass was achieved at 9 years of age. The bone mass stabilized after 9 years of age, showing no sign of further reduction with age. In contrast with the significant increase in bone mass before 2.5 years of age, significant decreases occurred in the serum concentrations of the following bone formation markers: intact osteocalcin, bone-specific alkaline phosphatase and amino-terminal propeptide of type I procollagen, but the serum concentration of carboxy-terminal propeptide of type I procollagen did not change significantly throughout the entire lifespan. Concerning the bone resorption markers, the levels of tartrate-resistant acid phosphatase fluctuated throughout the entire lifespan. The skeleton of an aging female monkey undergoes changes similar to those observed in senescent humans, but did not undergo the menopausal changes seen in women. The use of female cynomolgus monkeys to model human skeletal interventions should therefore be undertaken with consideration of the similarities and differences between cynomolgus monkeys and humans. Key words: bone densitometry, bone formation marker, bone resorption marker, cynomolgus monkeys, life span include reproductive endocrinology (menarche, regular menstruation and spontaneous menopause) [15], increases in bone turnover [20] and bone loss [26] in association with estrogen depletion, and skeletal microarchitecture as revealed by histomorphometry [19,

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Section: Introductionmentioning

confidence: 99%

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

et al. 2000

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“…Age-related bone loss has also been reported in several macaque species (Bowden et al 1979;Champ et al 1996;Colman et al 1999a, b;DeRousseau 1985;Grynpas et al 1993;Kessler et al 1986;Pope et al 1989;Przybeck 1985;Smith et al 2009;Binkley et al 1998;Brommage 2001;Fox et al 2007;Miller et al 1986), although none of these model systems replicate the osteoporotic fractures found in the human disease. To date, there is little information on the effect of aging interventions on the progression of agerelated bone loss.…”

Section: Introductionmentioning

confidence: 95%

Skeletal effects of long-term caloric restriction in rhesus monkeys

Colman

Beasley

Allison

et al. 2011

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Age-related bone loss is well established in humans and is known to occur in nonhuman primates. There is little information, however, on the effect of dietary interventions, such as caloric restriction (CR), on age-related bone loss. This study examined the effects of long-term, moderate CR on skeletal parameters in rhesus monkeys. Thirty adult male rhesus monkeys were subjected to either a restricted (R, n0 15) or control (C, n015) diet for 20 years and examined throughout for body composition and biochemical markers of bone turnover. Total body, spine, and radius bone mass and density were assessed by dualenergy X-ray absorptiometry. Assessment of biochemical markers of bone turnover included circulating serum levels of osteocalcin, carboxyterminal telopeptide of type I collagen, cross-linked aminoterminal telopeptide of type I collagen, parathyroid hormone, and 25(OH)vitamin D. Overall, we found that bone mass and density declined over time with generally higher levels in C compared to R animals. Circulating serum markers of bone turnover were not different between C and R with nonsignficant diet-by-time interactions. We believe the lower bone mass in R animals reflects the smaller body size and not pathological osteopenia.

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“…Metaphyses from frozen tibiae were individually crushed into powder using a Spex freezer mill (Edison, NJ) and total cellular RNA was extracted and isolated with a modified organic solvent method as described (32). Ten ]ig of total RNA from each sample was denatured in IM glyoxal, 50% dimethylsulfoxide 0.01 M NaH 2 P0 4 at 52°C, separated by electrophoresis on a 1% agarose gel, transferred by capillary action in 20X SSC to nylon membranes (Amersham Hybond nylon membrane, Arlington Heights, IL) and crosslinked using a UV source (Stratagen, LaJolla, CA) before hybridization procedures.…”

Section: Northern Hybridizationsmentioning

confidence: 99%

“…Representative Northern blots of bone extracts from ethanol and from PTH-treated rats are published (30,32).…”

Section: Northern Hybridizationsmentioning

confidence: 99%

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Alcohol and Adaptation to Mechanical Usage

Turner¹

2000

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503 AGENCY USE ONLY (Leave blank) REPORT DATE October 2000 REPORT TYPE AND DATES COVEREDAnnual (1 Sep 99 -31 Aug 00) TITLE AND SUBTITLE Alcohol and Adaptation to Mechanical Usage AUTHOR(S)Russell T. Turner, Ph.D. FUNDING NUMBERS DAMD17-98-1-8517 PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)Mayo Foundation Rochester, Minnesota 55905 E-MAIL: rolbiecki.lori@mayo.edu These studies are designed to determine whether ethanol antagonizes the ability of the skeleton to adapt to increased mechanical usage. Ethanol reversibly alters the biophysical properties of cell membranes.The overall hypothesis to be tested in adult rats is that these membrane changes disrupt essential cell signaling pathways for one or more cytokines, growth factors and polypeptide hormones that regulate bone modeling and remodeling.This report summarizes our progress from 01 September 1999 to 31 August 2000. During Year 2 of the award we have continued analysis of experiments performed in Year 1 related to Tasks 1-4 and 8.Additional experiments were performed to accomplish Task 8. Progress was also made on Tasks 6, 7, and 8.The new studies are directed toward determination of the effects of ethanol on: the skeletal readaptation to normal weight bearing following unloading (Task 6), skeletal adaptation to treadmill running (Task 7), PTH-induced increases in mRNA levels for bone matrix proteins (Task 8), and PTH-induced increases in osteoblast number and bone formation (Task 9). SUBJECT TERMS Neurotoxin NUMBER OF PAGES INTRODUCTIONChronic alcohol abuse is an important risk factor for osteoporosis. The ultimate goal of this research is to identify the cellular and molecular mechanisms responsible for mediating ethanol's dose-and time-dependent actions on bone turnover, mass, architecture, and strength. It is well established that ethanol reversibly alters the biophysical properties of cell membranes and in doing so disturbs normal membrane function. The proposed studies in young adult rats will test our working hypothesis that these membrane changes disrupt essential cell signaling pathways for one or more bone cells "coupling" factors and/or polypeptide hormones that regulate bone modeling and remodeling. These changes are postulated to lead to the bone loss associated with chronic alcohol abuse. If our hypothesis is correct, then ethanol antagonizes the ability of t...

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Effects of age and sex on bone density in the rhesus monkey

Cited by 69 publications

References 2 publications

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

Skeletal effects of long-term caloric restriction in rhesus monkeys

Alcohol and Adaptation to Mechanical Usage

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