“…The current metaanalysis was performed in order to examine the sequential responsiveness of animals exposed to PCOC in the Morris water-maze, a spatial navigation device [22,42,44,47,77,90,106]. Studies that have examined the effects of PCOC exposure on spatial navigation and memory performance in behavioral paradigms have yielded somewhat conflicting results and have used various non-uniform methodologies, making it difficult to discern the true effects of PCOC exposure [42,47,60,100]. Treatment differences have generally not been observed in the acquisition of water-maze performance in overall analyses across training days [6,22,42,44,63,77,90].…”