Effects of age and caloric restriction on the cardiac and coronary response to endothelin-1 in rats

Granado, Miriam; Rubio, Carmen; Amor, Sara; Monge, Luis; Fernández, Núria; Carreño‐Tarragona, Gonzalo; Carrascosa, Jóse M.; Garcı́a-Villalón, Ángel Luis

doi:10.1016/j.exger.2014.10.018

Cited by 5 publications

(2 citation statements)

References 35 publications

(31 reference statements)

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“…Previous studies have shown that iNOS levels are increased in diabetes (Demir et al ., ). In conditions where ET‐1 levels are increased, NO excretion decreases, and in response to this decrease iNOS expression is increased (Granado et al ., ). In the present study, parallel to increased ET‐1 levels, the iNOS mRNA level increased in the DM group.…”

Section: Discussionmentioning

confidence: 97%

Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats

et al. 2016

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To evaluate the protective role of bosentan (BOS), an endothelin-1 (ET-1) receptor antagonist, and to show the changes in rats with experimentally induced diabetic erectile dysfunction (ED), a total of 24 albino Wistar rats were allocated into four groups. Group 1 was the healthy group and Group 2 had diabetes mellitus (DM) induced by intraperitoneal injection of 60 mg kg streptozotocin (STZ). Following the establishment of DM, Group 3 and Group 4 were treated with oral BOS doses of 50 mg kg and 100 mg kg , respectively, for 60 days. At the end of the treatment, we evaluated yawning and erection response to apomorphine treatment and then the animals were sacrificed. ET-1, eNOS, iNOS, tumour necrosis factor (TNF)-α, ET-RA and ET-RB mRNA expressions were analysed in cavernosal tissue. It was observed that yawning and erection response decreased in the diabetic group; however, both of these improved with BOS treatment. While ET-1, TNF-α and iNOS gene expressions increased, eNOS, ET-RA and ET-RB gene expressions decreased in the DM group compared to the healthy group. DM has a negative impact on cavernosal tissue blood flow through activating vasoconstrictor mediators in cavernosal tissue. BOS regulates significantly eNOS, iNOS and TNF-α expressions in a dose-dependent manner.

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Section: Discussionmentioning

confidence: 97%

Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats

et al. 2016

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“…Despite the benefits of measuring plasma ET-1, plasma concentrations of ET-1 may not always be reflective of tissue or cellular ET-1; local concentrations of ET-1 are tissue dependent and can be 100-fold higher than plasma concentrations ( Battistini et al, 1993 ; Davenport et al, 2016 ). In animal models, aging is associated with increased expression of prepro-ET-1 mRNA, increased expression of ECE-1, greater stimulated release of ET-1, ( Goel et al, 2010 ) and greater ET-1 expression in the coronary artery ( Granado et al, 2014 ). Aging increases the number of secretagogues that can stimulate the ET system leading to increased activity.…”

Section: Et-1 Aging and Sexmentioning

confidence: 99%

ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function

et al. 2021

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Aging is a primary risk factor for cardiovascular disease (CVD), which is the leading cause of death in developed countries. Globally, the population of adults over the age of 60 is expected to double by the year 2050. CVD prevalence and mortality rates differ between men and women as they age in part due to sex-specific mechanisms impacting the biological processes of aging. Measures of vascular function offer key insights into cardiovascular health. Changes in vascular function precede changes in CVD prevalence rates in men and women and with aging. A key mechanism underlying these changes in vascular function is the endothelin (ET) system. Studies have demonstrated sex and sex hormone effects on endothelin-1 (ET-1), and its receptors ETA and ETB. However, with aging there is a dysregulation of this system resulting in an imbalance between vasodilation and vasoconstriction. Thus, ET-1 may play a role in the sex differences observed with vascular aging. While most research has been conducted in pre-clinical animal models, we describe more recent translational data in humans showing that the ET system is an important regulator of vascular dysfunction with aging and acts through sex-specific ET receptor mechanisms. In this review, we present translational evidence (cell, tissue, animal, and human) that the ET system is a key mechanism regulating sex-specific changes in vascular function with aging, along with therapeutic interventions to reduce ET-mediated vascular dysfunction associated with aging. More knowledge on the factors responsible for the sex differences with vascular aging allow for optimized therapeutic strategies to attenuate CVD risk in the expanding aging population.

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Effects of age and caloric restriction in the vascular response of renal arteries to endothelin-1 in rats

Amor

Garcı́a-Villalón

Rubio

et al. 2017

Experimental Gerontology

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Effects of age and caloric restriction on the cardiac and coronary response to endothelin-1 in rats

Cited by 5 publications

References 35 publications

Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats

Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats

ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function

Effects of age and caloric restriction in the vascular response of renal arteries to endothelin-1 in rats

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