Effects of age and anxiety on learning and memory

Küçük, Ayşegül; Gölgeli, Asuman; Saraymen, Recep; Koç, Nedret

doi:10.1016/j.bbr.2008.05.023

Cited by 58 publications

(26 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Physiologically, the impairments are associated with deficits in glutamatergic, GABAergic, dopaminergic, cholinergic and serotonergic neurotransmitter systems. Serotonergic neurotransmitter system contribute to the deficit through its influence on dopaminergic, cholinergic, glutamatergic, GABAergic and growth factors and receptor functions all important in schizophrenia and cognitive status (Gray and Roth 2007;Millan 2000;Küçük et al 2008;Mora et al 1997;Zhou et al 2008;Bantick et al 2001). Additional studies are required to determine the specific neural mechanisms responsible for the observed patterns on learning and memory.…”

Section: Discussionmentioning

confidence: 95%

Memory deficits associated with khat (Catha edulis) use in rodents

2015

View full text Add to dashboard Cite

Khat products and chewing practices are common in East Africa, Middle East for centuries with concomitant socio-economic and public health repercussions. We assessed memory deficits associated with khat use in rodents. Young male CBA mice, 5-7 weeks old (n = 20), weighing 25-35 g were used. Mice were treated with either 40, 120 or 360 mg/kg body weight (bw) methanolic khat extract, or 0.5 ml saline for 10 days. Spatial acquisition, reversal and reference memory were assessed using modified Morris Water maze (MMWM). Mice treated with 40 mg/kg khat extract had longer (t4 = 4.12 p = 0.015) and t4 = 2.28 p = 0.065) escape latency on first and second day during reversal relative to the baseline. Under 120 mg/kg khat dose, the escape latency was shorter (t4 = -2.49 p = 0.05) vs (t3 = -2.5 p = 0.05) on third and fourth day. Further, treatment with 360 mg/kg khat extract resulted in significantly longer time (49.13, 33.5, 40.2 and 35.75) vs. (23.5 s), compared to baseline. Mice treated with khat or control preferred the target quadrant post acquisition while differential pattern was seen during reversal phase. Mice treated with 40 or 120 mg/kg khat showed significant preference for target quadrant. Substantial time (19.9) was spent in the old target compared to the new (16.9 s) by animals treated with highest dose however, the difference was not significant. There is a biological plausibility that chronic khat use may induce memory deficits and impair cognitive flexibility. The differential patterns of memory deficits may reflect the differences in dose effect as well as time dependent impairment.

show abstract

Section: Discussionmentioning

confidence: 95%

Memory deficits associated with khat (Catha edulis) use in rodents

2015

View full text Add to dashboard Cite

show abstract

“…Cognitive functions were assayed in the MWM test. This test allows to evaluate learning ability and memory of rodents in spatial memory disorders (Brandeis et al, 1989;Moghaddam and Bures, 1997) and in aging (Joseph et al, 1999;Kiray et al, 2006;Küç ük et al, 2008). Several studies have suggested that old-aged rats exhibit reduced spatial memory in the MWM as compared to young rats, whereas young and middle-aged animals do not differ from each other (Blalock et al, 2003).…”

Section: Discussionmentioning

confidence: 97%

Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats

Stefanova¹,

Фурсова²,

Sarsenbaev³

et al. 2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…The MWM has been used extensively to measure cognitive deficits in spatial memory in lesion studies [40,41] and in aging [1,3,42,43]. It is known that old rats show reduced spatial memory on this test compared to young rats, while young and middle-aged animals do not differ from each other [44].…”

Section: Discussionmentioning

confidence: 99%

Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats

Stefanova

Фурсова

Kolosova

2010

JAD

View full text Add to dashboard Cite

Abstract. Mitochondrial dysfunction is involved in aging and in neurodegenerative diseases and, therefore, pharmacological agents that alleviate mitochondrial dysfunction are expected to have neuroprotective effects. Promising in this respect is mitochondrial-targeted antioxidant plastoquinonyl-decyl-triphenylphosphonium (SkQ1). We investigated the effects of SkQ1 (250 nmol SkQ1/kg × day with food) on behavior in the elevated plus-maze (EPM) and open field (OF) and on spatial memory in a Morris water maze (MWM) in middle-aged (12 mo) Wistar and senescence-accelerated OXYS rats. Given that changes in the behavior of OXYS rats may be associated with visual impairment, the condition of the retina and the lens was evaluated by ophthalmoscopy. 14-month-old as well as 3-month-old OXYS rats had considerably reduced activities in OF, increased anxiety in EPM, and manifested impaired learning abilities in the MWM in comparison with Wistar rats. SkQ1-treated rats of both strains displayed significantly higher locomotor and exploratory activity in the OF and less anxiety in the EPM compared to age-matched controls. SkQ1 significantly improved visual ability of the rats reducing the severity of the developed signs of retinopathy and cataract but had no impact on OXYS rat's spatial memory in the MWM. SkQ1-treated Wistar rats exhibited slower learning in the MWM task comparison to the control group. Thus, SkQ1 had beneficial effects on locomotor and exploratory functions of the rat brain. Nevertheless, SkQ1 did not alter learning performance in the MWM in OXYS rats and slightly reduced it in the Wistar strain, which may be associated with differences in redox homeostasis.

show abstract

Effects of age and anxiety on learning and memory

Cited by 58 publications

References 47 publications

Memory deficits associated with khat (Catha edulis) use in rodents

Memory deficits associated with khat (Catha edulis) use in rodents

Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats

Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats

Contact Info

Product

Resources

About