Effects of Aerobic Training on Cognition and Brain Glucose Metabolism in Subjects with Mild Cognitive Impairment

Porto, Fábio Henrique de Gobbi; Coutinho, Artur Martins; Pinto, Ana Lúcia de Sá; Gualano, Bruno; Duran, Fábio Luís de Souza; Prando, Silvana; Ono, Carla Rachel; Spíndola, Lívia; Oliveira, Maira Okada de; Vale, Patrícia Helena Figuerêdo do; Nitrini, Ricardo; Buchpiguel, Carlos Alberto

doi:10.3233/jad-150033

Cited by 25 publications

(20 citation statements)

References 64 publications

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“…Results from this pilot study support growing evidence that shows physical activity or exercise benefits cognitive function in older adults with MCI. 13 – 17 , 37 The finding on the improved ADAS-Cog scores is consistent with previous exercise-based interventions involving home-based aerobic 13 and multimodal exercises. 14 To the best of our knowledge, this is the first time that a momentum-based dumbbell-training approach has been used to target change in cognition function.…”

Section: Discussionsupporting

confidence: 88%

Effects of momentum-based dumbbell training on cognitive function in older adults with mild cognitive impairment: a pilot randomized controlled trial

Lü¹,

Sun²,

Liang³

et al. 2015

CIA

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PurposeThe purpose of this study was to explore the effects of an innovative momentum-based dumbbell-training intervention on cognitive function in older adults with mild cognitive impairment (MCI).Subjects and methodsA total of 45 community-dwelling older adults with MCI were randomly assigned to either a dumbbell-training group (DTG; n=22) or a control group (CG; n=23). Participants in the DTG participated in exercise sessions three times weekly for 12 weeks. The primary outcome measures were cognitive function, including the Alzheimer’s Disease Assessment Scale (ADAS) – Cognitive subscale, Trail Making Test part B, Digit Span Test (DST) – forward, and DST – backward, with secondary outcome measures being Timed Up and Go, functional reach, and the Activities-Specific Balance Confidence Scale.ResultsIn an intent-to-treat analysis, participants in the DTG had significantly improved ADAS – Cognitive subscale scores compared to those in the CG (5.02 points, P=0.012). There was a significant within-group change (improvement) in Trail Making Test part B (33.32 seconds, P<0.001) and DST – backward (0.41 points, P=0.025) scores. No change was observed for the DST – forward measure. Participants in the DTG also improved their functional mobility compared to those in the CG (Timed Up and Go, 0.81 seconds; P=0.043).ConclusionThere is preliminary evidence showing the potential benefit of momentum-based dumbbell training for improving cognitive function in older adults with MCI.

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Section: Discussionsupporting

confidence: 88%

Effects of momentum-based dumbbell training on cognitive function in older adults with mild cognitive impairment: a pilot randomized controlled trial

Lü¹,

Sun²,

Liang³

et al. 2015

CIA

View full text Add to dashboard Cite

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“…While others have reported that acute aerobic exercise [46] and aerobic training interventions [47] can alter cerebral glucose metabolism, our findings suggest that engagement in MPA, specifically, may promote cerebral glucose metabolism among cognitively normal late-middle-aged adults at risk for AD. While we cannot draw definitive conclusions regarding causation in this study, our findings, in the context of the literature suggest PA tracks closely with cerebral glucose metabolism.…”

Section: Discussioncontrasting

confidence: 63%

Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer’s Disease

Dougherty

Schultz

Kirby

et al. 2017

JAD

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The objective of this study was to investigate the relationship between accelerometer-measured physical activity (PA) and glucose metabolism in asymptomatic late-middle-aged adults. Ninety-three cognitively healthy late-middle-aged adults from the Wisconsin Registry for Alzheimer’s Prevention participated in this cross-sectional study. They underwent 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and wore an accelerometer (ActiGraph GT3X+) to measure free-living PA. Accelerometer data yielded measures of light (LPA), moderate (MPA), and vigorous (VPA) intensity PA. FDG-PET images were scaled to the cerebellum and pons, and cerebral glucose metabolic rate was extracted from specific regions of interest (ROIs) known to be hypometabolic in AD, i.e., hippocampus, posterior cingulate, inferior temporal cortex, and angular gyrus. Regression analyses were utilized to examine the association between PA and glucose metabolism, while adjusting for potential confounds. There were associations between MPA and glucose metabolism in all ROIs examined. In contrast, LPA was not associated with glucose uptake in any ROI and VPA was only associated with hippocampal FDG uptake. Secondary analyses did not reveal associations between sedentary time and glucose metabolism in any of the ROIs. Exploratory voxel-wise analysis identified additional regions where MPA was significantly associated with glucose metabolism including the precuneus, supramarginal gyrus, amygdala, and middle frontal gyrus. These findings suggest that the intensity of PA is an important contributor to neuronal function in a late-middle-aged cohort, with MPA being the most salient. Prospective studies are necessary for fully elucidating the link between midlife engagement in PA and later life development of AD.

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“…Our findings are in accordance with a previous study demonstrating that aerobic exercise training may benefit brain glucose metabolism. Porto and colleagues reported that 24 weeks of aerobic exercise training increased PCC glucose metabolism among individuals with MCI [47]. Their exercise training was similar in session duration, intensity, and intervention duration, but was lower in total training volume (i.e., two sessions/week) and the improvement in CRF was approximately half of that observed in our Enhanced PA group.…”

Section: Discussionmentioning

confidence: 59%

Brain Glucose Metabolism, Cognition, and Cardiorespiratory Fitness Following Exercise Training in Adults at Risk for Alzheimer’s Disease

Gaitán

Boots

Dougherty

et al. 2019

BPL

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Aerobic exercise has been associated with reduced burden of brain and cognitive changes related to Alzheimer's disease (AD). However, it is unknown whether exercise training in asymptomatic individuals harboring risk for AD improves outcomes associated with AD. We investigated the effect of 26 weeks of supervised aerobic treadmill exercise training on brain glucose metabolism and cognition among 23 late-middle-aged adults from a cohort enriched with familial and genetic risk of AD. They were randomized to Usual Physical Activity (PA) or Enhanced PA conditions. Usual PA received instruction about maintaining an active lifestyle. Enhanced PA completed a progressive exercise training program consisting of 3 sessions of treadmill walking per week for 26 weeks. By week seven, participants exercised at 70-80% heart rate reserve for 50 minutes per session to achieve 150 minutes of moderate intensity activity per week in accordance with public health guidelines. Before and after the intervention, participants completed a graded treadmill test to assess VO 2 peak as a measure of cardiorespiratory fitness (CRF), wore an accelerometer to measure free-living PA, underwent 18 F-fluorodeoxyglucose positron emission tomography imaging to assess brain glucose metabolism, and a neuropsychological battery to assess episodic memory and executive function. VO 2 peak increased, sedentary behavior decreased, and moderate-to-vigorous PA increased significantly in the Enhanced PA group as compared to Usual PA. Glucose metabolism in the posterior cingulate cortex (PCC) did not change significantly in Enhanced PA relative to Usual PA. However, change in PCC glucose metabolism correlated positively with change in VO 2 peak. Executive function, but not episodic memory, was significantly improved after

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Effects of Aerobic Training on Cognition and Brain Glucose Metabolism in Subjects with Mild Cognitive Impairment

Abstract: AT improved cognition and changed rBGM in areas related to cognition in subjects with MCI.

Cited by 25 publications

References 64 publications

Effects of momentum-based dumbbell training on cognitive function in older adults with mild cognitive impairment: a pilot randomized controlled trial

Effects of momentum-based dumbbell training on cognitive function in older adults with mild cognitive impairment: a pilot randomized controlled trial

Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer’s Disease

Brain Glucose Metabolism, Cognition, and Cardiorespiratory Fitness Following Exercise Training in Adults at Risk for Alzheimer’s Disease

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