Effects of Aerobic, Resistance and Combined Training on Endothelial Function and Arterial Stiffness in Older Adults: Study Protocol for a Systematic Review and Meta-Analysis

Abstract

Introduction: Aging is an independent risk factor for cardiovascular events. It promotes vascular dysfunction which is associated with risk factors for cardiovascular diseases (CVDs). Exercise can modulate vascular function parameters, but little is known about the effects of different modalities of training (aerobic, resistance and combined) on endothelial function and arterial stiffness in older adults. Methods: This systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE and Web of Science. We will follow the PRISMA guidelines and PICOS framework. Studies involving both male and female older adults (≥60 years old) with or without comorbidities undergoing aerobic, resistance and/or combined training compared to a control group (no exercise) will be eligible. We will use Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of individual studies and GRADE to assess the strength of evidence. Statistical analyses will be conducted with RStudio for Windows (v1.3.959) using R package meta. Discussion: A systematic review and meta-analysis involving data from studies of older adults would deepen our understanding of vascular adaptations to exercise training in this population. It could provide new insights into how health providers can improve patient management and prevention of cardiovascular events in older adults. Systematic Review Registry: The study protocol for this review is awaiting approval for registration in the International Prospective Register of Systematic Reviews (PROSPERO) (ID 42021275451).