Effects of adult-onset calorie restriction on anxiety-like behavior in rats

Levay, Elizabeth A.; Govic, Antonina; Penman, Jim; Paolini, Antonio G.; Kent, Stephen

doi:10.1016/j.physbeh.2007.06.018

Cited by 68 publications

(54 citation statements)

References 28 publications

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“…In contrast, another report with male and female mice did not observe such decrease in anxiety-like behavior [40]. Alternatively, because behavioral changes in our study were observed in very similar ways in both experimental groups, it should be considered that the food restriction itself might have had the anxiolytic effect on juvenile mice, consistent with previous dietary restriction studies [41], [42], [43]. In the present study, locomotor activities among groups did not affect behavioral results because the total distance during the EPM and %freezing during acclimation period were not significantly different among groups.…”

Section: Discussionsupporting

confidence: 85%

Methyl Donor-Deficient Diet during Development Can Affect Fear and Anxiety in Adulthood in C57BL/6J Mice

et al. 2014

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DNA methylation is one of the essential factors in the control of gene expression. Folic acid, methionine and choline (methyl donors)–all nutrients related to one-carbon metabolism–are known as important mediators of DNA methylation. A previous study has shown that long-term administration of a diet lacking in methyl donors caused global DNA hypermethylation in the brain (Pogribny et al., 2008). However, no study has investigated the effects of a diet lacking in methyl donors during the developmental period on emotional behaviors such as fear and anxiety-like behavior in association with gene expressions in the brain. In addition, it has not been elucidated whether a diet supplemented with methyl donors later in life can reverse these changes. Therefore, we examined the effects of methyl donor deficiency during the developmental period on fear memory acquisition/extinction and anxiety-like behavior, and the relevant gene expressions in the hippocampus in juvenile (6-wk) and adult (12-wk) mice. We found that juvenile mice fed a methyl-donor-deficient diet had impaired fear memory acquisition along with decreases in the gene expressions of Dnmt3a and Dnmt3b. In addition, reduced anxiety-like behavior with decreased gene expressions of Grin2b and Gabar2 was observed in both the methyl-donor-deficient group and the body-weight-matched food-restriction group. After being fed a diet supplemented with methyl donors ad libitum, adult mice reversed the alteration of gene expression of Dnmt3a, Dnmt3b, Grin2b and Gabar2, but anxiety-like behavior became elevated. In addition, impaired fear-memory formation was observed in the adult mice fed the methyl-donor-deficient diet during the developmental period. Our study suggested that developmental alterations in the one-carbon metabolic pathway in the brain could have effects on emotional behavior and memory formation that last into adulthood.

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Section: Discussionsupporting

confidence: 85%

Methyl Donor-Deficient Diet during Development Can Affect Fear and Anxiety in Adulthood in C57BL/6J Mice

et al. 2014

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“…These results indicate that stereotypical behaviors shown in the 60% food-restricted group have no relation with motor function. It has been reported that dietary restriction may induce anxiety-like behavior by down-regulation of corticotrophin-releasing factor (64). Diet-restricted rats showed stereotypy by an increase of dopamine receptor signaling (65).…”

Section: Oligomeric Proanthocyanidins Extend Life Span Of Samp8mentioning

confidence: 98%

Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits

Yokozawa

Lee

Cho

et al. 2011

DD&T

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Senescence-accelerated mouse prone/8 (SAMP8), a murine model of accelerated senescence, shows age-related deficits in learning and memory. The oral administration of oligomers improved spatial and object recognition impairment in SAMP8. The expression of phosphorylated neurofilament-H was significantly elevated in the hippocampal CA1. This indicates that oligomers induce an increase in the density of axons. To investigate the protective mechanisms of oligomers against brain dysfunction with aging, we carried out a receptor tyrosine kinase phosphorylation antibody array, and clarified that the administration of oligomers led to an increase in the phosphorylation of vascular endothelial growth factor receptor (VEGFR)-2, suggesting the neuroprotective role of oligomers. The phosphorylation of VEGFR-2 was more markedly increased in the hypothalamus and choroid plexus than in other brain regions of SAMP8. Memory in oligomer-treated mice was impaired by SU1498, a VEGFR-2-specific antagonist. Elucidating the relationship between memory impairment with aging and VEGFR-2 signaling may provide new suggestions for protection against memory deficit in the aging brain. In addition, we revealed that the administration of oligomers extended the life span of SAMP8. Oligomers elevated SIRT1 expression, which is recognized as an essential factor for life span extension in the brain. However, the administration of oligomers did not induce stereotypical behaviors such as rearing, jumping, or hanging from the lid of a cage, while food restriction increased these frequencies without a significant change in motor function. The present study suggests the promising role of oligomers as an anti-aging agent to extend life span.

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“…These parameters are expressed as percentage of total ambulatory, rearing and stereotype counts, respectively. Low percentage of activities in the central area could represent behaviour correlated with anxiety (19). Between each test session, the apparatus was cleaned with alcohol (10%) and dried with a cloth.…”

Section: Measurement Oflocomotor Activitymentioning

confidence: 99%

Effects and Trimethyltin on Hippocampal Dopaminergic Markers and Cognitive Behaviour

Mignini

Nasuti

Artico

et al. 2012

Int J Immunopathol Pharmacol

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The triorganotin compound trimethyltin (TMT) is a highly toxic molecule which has a great impact on human health. The aim of this study was to investigate the specific alteration of dopamine receptors and transporters in the hippocampus of TMT-treated rats. The TMT-treated group showed impaired spatial reference memory in a Morris water maze task compared to the control group, whereas memory consolidation tested 24 hours after the last training session was preserved. In the open field, TMT-treated rats showed a decrease in time spent in rearing episodes reflecting a lower interest to explore a novel environment. In the hippocampal area of the TMT-treated group, we observed a reduction in neuronal viability accompanied by a significant decrease in the expression of the dopamine receptors (D1 and D2), and dopamine transporters (DAT, VMAT1 and VMAT2). A less pronounced reduction was observed for D3 and D5 while D4 did not change. These data were confirmed by RT-PCR analysis. The present study on TMT-induced neurodegeneration highlights the link between hippocampal asset of dopamine receptors and transporters and the impaired performance of rats in a spatial reference memory task.

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Effects of adult-onset calorie restriction on anxiety-like behavior in rats

Cited by 68 publications

References 28 publications

Methyl Donor-Deficient Diet during Development Can Affect Fear and Anxiety in Adulthood in C57BL/6J Mice

Methyl Donor-Deficient Diet during Development Can Affect Fear and Anxiety in Adulthood in C57BL/6J Mice

Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits

Effects and Trimethyltin on Hippocampal Dopaminergic Markers and Cognitive Behaviour

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