Effects of Adrenal Medullary Hormones on Renal Excretion of Water and Electrolytes

Eversole, W. J.; Giere, Frederic A.; Rock, Martha

doi:10.1152/ajplegacy.1952.170.1.24

Cited by 15 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their administration caused diuresis in rabbits (32,33) and rats (34)(35)(36), and either diuresis or antidiuresis in dogs (37)(38)(39). Epinephrine and norepinephrine also can produce either effect (32,(40)(41)(42)(43)(44)(45). In all these, as well as in our own experiments, the circumstances that dictate one effect rather than the other remain unclear.…”

Section: Discussionmentioning

confidence: 64%

Angiotensin Ii, Norepinephrine, and Renal Transport of Electrolytes and Water in Normal Man and in Cirrhosis With Ascites*

Laragh

Cannon²,

Bentzel³

et al. 1963

J. Clin. Invest.

199

View full text Add to dashboard Cite

In normal subjects, the rate of aldosterone secretion fluctuates widely according to the state of salt and water balance, but the pathways mediating this relationship are still to be identified. Hypersecretion of aldosterone occurs in malignant nephrosclerosis (2). Angiotensin, the pressor peptide released from plasma by renin, increases both the adrenal secretion (3) and the urinary excretion (4) of aldosterone in man. These observations support the suggestion (5) that a renaladrenal interaction might be involved in the normal regulation of sodium and potassium balance. By this mechanism, the kidney, perhaps sensitive to diminished arterial filling or ischemia, secretes renin, generating angiotensin, which then stimulates aldosterone secretion. Aldosterone, in turn, restores renal perfusion by promoting sodium and water retention.In malignant hypertension this mechanism may become deranged, leading to the coexistence of increased amounts of both angiotensin and aldosterone in the blood, a possibility that derives additional support from the earlier report (6) of increased blood angiotensin in these patients. On the other hand, since neither renin nor angiotensin has been conclusively demonstrated in normal human plasma, elaboration of these substances in malignant hypertension might be simply a consequence of severe renal damage.Our more recent work has investigated the possibility that this renal-adrenal interaction participates in normal homeostasis, as well as in the *This report was presented in part at the 54th an-

show abstract

Section: Discussionmentioning

confidence: 64%

Angiotensin Ii, Norepinephrine, and Renal Transport of Electrolytes and Water in Normal Man and in Cirrhosis With Ascites*

Laragh

Cannon²,

Bentzel³

et al. 1963

J. Clin. Invest.

199

View full text Add to dashboard Cite

show abstract

“…Gross & Schneider (95) reported that epinephrine and norepinephrinf. In saline-loaded rats norepinephrine increased the urine flow while epinephrine reduced it (69) . It is suggested that epinephrine releases a sub stance in the spleen with norepinephrine-like actions.…”

Section: Peripheral Visceral Efferent System Thoracolumbar Outflowmentioning

confidence: 87%

Visceral Functions of the Nervous System

Euler¹

1954

Annu. Rev. Physiol.

View full text Add to dashboard Cite

Of the numerous important contributions to the subject special mention might be made of the new information gathered on the central representation of a number of visceral functions and the new approaches to the understand ing of the interrelations between psychic activity on a wider basis and the visceral functions. Also the mechanisms by which mental disorders and vari ous kinds of stress situations influence the automically regulated processes constitute an important lead in a comparatively new line of research. CEREBRAL CORTEXIn a thought-provoking article Hess (106) discusses the relations between experimental physiology and psychology and points at the fact that certain affective responses produce effects comparable with specific emotional pat terns. He concludes that such phenomena can only be explained by assum ing a cortical action in conjunction with lower levels of the central nervous system since such reactions can be elicited from circumscribed areas in the thalamus and hypothalamus. Thus subcortical processes must be linked up with consciousness. From the standpoint of psychiatry these concepts are obviously of high significance and should form a profitable basis for further psychiatric research, the urgent need of which has been stressed (129).The interrelation between the cortex and the brain stem in behaviour has also been the subject of an interesting article by Ingram (116). He re ported that relatively small lesions in the ventromedial hypothalamic nuclei caused an extreme, chronic, and incurable savageness in cats, suggesting that these areas serve as an inhibitory center for the rage impulses originating in other areas. Since the activity is well directed and discriminating the malevolent attitude of savage cats apparently involves some cortical mecha nisms which probably are operating also after destruction of the ventromedial hypothalamic area.

show abstract

“…Eversole, Giere & Rock (1952) found that noradrenaline caused an increase of glomerular filtration rate and also an apparent decrease in tubular reabsorption of water. Glomerular filtration rate is also likely to increase with diuretic amounts of adrenaline and bretylium.…”

Section: Discussionmentioning

confidence: 99%

Diuresis in Rats: Effects of Sympathomimetic and Sympathetic Blocking Agents

Green

Sim

1961

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

Dopamine and tyramine possess diuretic properties resembling but weaker than those of noradrenaline in the rat. These three amines produce a relatively smaller loss of sodium than does adrenaline. Bretylium shows a diuretic action which is apparently associated with its sympathomimetic properties and which is antagonized by phenoxybenzamine. However, bretylium causes a relatively greater loss of potassium and chloride than do the sympathomimetic amines. A slight antidiuretic action is shown by bretylium after its diuretic effect has subsided and a similar effect is produced by BW 172C58, which has relatively weak sympathomimetic properties. In contrast to these adrenergic neurone blocking agents, phenoxybenzamine and a ganglion blocking agent (pentacynium) show powerful antidiuretic effects. These observations are consistent with the view that the adrenal medulla has an important role in facilitating water diuresis in rats.

show abstract

Effects of Adrenal Medullary Hormones on Renal Excretion of Water and Electrolytes

Cited by 15 publications

References 0 publications

Angiotensin Ii, Norepinephrine, and Renal Transport of Electrolytes and Water in Normal Man and in Cirrhosis With Ascites*

Angiotensin Ii, Norepinephrine, and Renal Transport of Electrolytes and Water in Normal Man and in Cirrhosis With Ascites*

Visceral Functions of the Nervous System

Diuresis in Rats: Effects of Sympathomimetic and Sympathetic Blocking Agents

Contact Info

Product

Resources

About