Effects of adjunctive lacosamide on mood and quality of life in patients with epilepsy

Nakhutina, Luba; Kunnakkat, Saroj; Coleman, Madeleine; Lushbough, Catherine; Arnedo, Vanessa; Soni, Nirali; Grant, Arthur C.

doi:10.1016/j.yebeh.2017.05.001

Cited by 16 publications

(7 citation statements)

References 20 publications

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“…We also noted positive behavioural effects in 10.6% of our subjects. A positive effect of lacosamide on mood has been reported in other studies as well [24]. Somatic side effects were reported less often in PWID than in the general population, which may indicate under-reporting due to limitations in communication skills.…”

Section: Discussionsupporting

confidence: 62%

The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions

Brenner

Majoie

Beek

et al. 2017

Seizure

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Section: Discussionsupporting

confidence: 62%

The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions

Brenner

Majoie

Beek

et al. 2017

Seizure

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“…A former study concluded that LCM as an adjuvant treatment for levetiracetam can significantly increase the QOLIE-10 score of patients with refractory epilepsy and reduce the occurrence of anxiety and depression in patients (32). In addition, LCM as an adjuvant drug can improve cognitive function and the mental state of patients with epilepsy (33). The results of the present study and the aforementioned studies indicated that levetiracetam treatment supplemented by LCM can improve the mood and quality of life of patients with epilepsy.…”

Section: Discussionsupporting

confidence: 66%

Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy

Liu

Wang

2020

Exp Ther Med

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The present study aimed to investigate the effects of levetiracetam tablets and lacosamide (LCM) on therapeutic efficacy and neural function in patients with epilepsy. We assigned 252 patients with refractory partial seizures admitted to our hospital to receive either levetiracetam tablets [120 patients, the control group (CG)] or levetiracetam tablets combined with LCM [132 patients, the joint group (JG)]. The bone mineral density and neural function between the two groups at 6 months before and after treatment were compared. The total response rate was higher in the JG than in the CG (P<0.05). There was no significant difference in the comparison of the multiple indexes between the two groups before treatment (P>0.05). The frequency of seizures was reduced after treatment in the two groups, however, it was lower in the JG compared with the CG (P<0.05). The levels of neurological indicators were significantly reduced after treatment in the two groups (P<0.05), however, the reduction was more marked in the JG than in the CG. The bone mineral density (BMD) of the femoral neck decreased after treatment in the two groups (P<0.05), but there was no difference between the two groups after treatment (P>0.05). The calcium content decreased after treatment in the two groups (P<0.05), but there was no difference between the two groups after treatment (P>0.05). The comparison of other bone metabolism markers between the two groups exhibited no significant differences. The combination therapy greatly increased the quality of life score and the 1-year drug retention rate. To sum up, levetiracetam tablets combined with LCM significantly enhanced the therapeutic effect and improved the neural function in patients with refractory partial seizures, however this therapy may cause a slight adverse effect on BMD and bone metabolism in the short term.

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“…Lacosamide (LCM) is a third-generation AED approved for focal epilepsy treatment. The suppression of voltage-gated sodium channels has been proposed to be a main mechanism of the drug anticonvulsant activity [16]. Although the pharmacological activity of these drugs has been well studied, little is known about the effects of TPM and LCM on oxidative stress and neuroinflammation, outlined as major contributors in the subsequent processes of epileptogenesis.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation

Shishmanova-Doseva

Peychev

Yoanidu

et al. 2021

IJMS

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Background: Status epilepticus (SE) is a neurological disorder characterized by a prolonged epileptic activity followed by subsequent epileptogenic processes. The aim of the present study was to evaluate the early effects of topiramate (TPM) and lacosamide (LCM) treatment on oxidative stress and inflammatory damage in a model of pilocarpine-induced SE. Methods: Male Wistar rats were randomly divided into six groups and the two antiepileptic drugs (AEDs), TPM (40 and 80 mg/kg, i.p.) and LCM (10 and 30 mg/kg, i.p.), were injected three times repeatedly after pilocarpine administration. Rats were sacrificed 24 h post-SE and several parameters of oxidative stress and inflammatory response have been explored in the hippocampus. Results: The two drugs TPM and LCM, in both doses used, succeeded in attenuating the number of motor seizures compared to the SE-veh group 30 min after administration. Pilocarpine-induced SE decreased the superoxide dismutase (SOD) activity and reduced glutathione (GSH) levels while increasing the catalase (CAT) activity, malondialdehyde (MDA), and IL-1β levels compared to the control group. Groups with SE did not affect the TNF-α levels. The treatment with a higher dose of 30 mg/kg LCM restored to control level the SOD activity in the SE group. The two AEDs, in both doses applied, also normalized the CAT activity and MDA levels to control values. In conclusion, we suggest that the antioxidant effect of TPM and LCM might contribute to their anticonvulsant effect against pilocarpine-induced SE, whereas their weak anti-inflammatory effect in the hippocampus is a consequence of reduced SE severity.

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Effects of adjunctive lacosamide on mood and quality of life in patients with epilepsy

Cited by 16 publications

References 20 publications

The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions

The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions

Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy

Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation

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