Effects of adenosine analogues on apomorphine-induced penile erection in rats

Sharifzadeh, Mohammad; Zarrindast, M.R.; Samini, Morteza

doi:10.1016/0306-3623(95)00114-x

Cited by 15 publications

(20 citation statements)

References 44 publications

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“…However, studies of the role of adenosine signaling in penile vascular function are very limited. Earlier studies in several animal species, including humans (20), showed that intracavernous injection of adenosine resulted in tumescence and penile erection (14)(15)(16)(17)(18)(19). These findings suggest that adenosine may contribute to penile erection.…”

Section: Discussionmentioning

confidence: 91%

“…Second, both have a very short half life (<10 s) (13). Third, both induce cyclic nucleotide second messengers and penile erection (14)(15)(16)(17)(18)(19). Specifically, adenosine functions through G protein-coupled receptors to modulate adenylyl cyclase and the synthesis of cAMP.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, adenosine-mediated cAMP induction and NO-mediated cGMP induction are capable of inducing protein kinase A and protein kinase G, respectively, resulting in decreased calcium/calmodulin-dependent myosin light chain phosphorylation and enhanced smooth muscle relaxation (14). Earlier studies in multiple animal species, including humans (20), showed that intracavernous injection of adenosine resulted in tumescence and penile erection (14)(15)(16)(17)(18)(19). Theophylline, an adenosine receptor antagonist, inhibited adenosine-induced penile tumescence (21).…”

Section: Introductionmentioning

confidence: 99%

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Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Mi¹,

Abbasi²,

Zhang³

et al. 2008

J. Clin. Invest.

131

221

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Priapism, abnormally prolonged penile erection in the absence of sexual excitation, is associated with ischemia-mediated erectile tissue damage and subsequent erectile dysfunction. It is common among males with sickle cell disease (SCD), and SCD transgenic mice are an accepted model of the disorder. Current strategies to manage priapism suffer from a poor fundamental understanding of the molecular mechanisms underlying the disorder. Here we report that mice lacking adenosine deaminase (ADA), an enzyme necessary for the breakdown of adenosine, displayed unexpected priapic activity. ADA enzyme therapy successfully corrected the priapic activity both in vivo and in vitro, suggesting that it was dependent on elevated adenosine levels. Further genetic and pharmacologic evidence demonstrated that A 2B adenosine receptor-mediated (A 2B R-mediated) cAMP and cGMP induction was required for elevated adenosine-induced prolonged penile erection. Finally, priapic activity in SCD transgenic mice was also caused by elevated adenosine levels and A 2B R activation. Thus, we have shown that excessive adenosine accumulation in the penis contributes to priapism through increased A 2B R signaling in both Ada -/-and SCD transgenic mice. These findings provide insight regarding the molecular basis of priapism and suggest that strategies to either reduce adenosine or block A 2B R activation may prove beneficial in the treatment of this disorder.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Mi¹,

Abbasi²,

Zhang³

et al. 2008

J. Clin. Invest.

131

221

View full text Add to dashboard Cite

show abstract

“…Adenosine is a signaling nucleoside that shares multiple features with NO; both are potent vasodilators, induce cyclic nucleotide second messengers and both affect penile erection. [74][75][76][77][78] Recent studies in both animals and humans have shown that intracavernous injection of adenosine results in tumescence and penile erection, providing evidence that excess adenosine may contribute to priapism. [74][75][76] Theophylline, an adenosine receptor antagonist, has consequently been shown to inhibit these adenosine-induced erections.…”

Section: Intracavernosal Injectionsmentioning

confidence: 99%

“…[74][75][76][77][78] Recent studies in both animals and humans have shown that intracavernous injection of adenosine results in tumescence and penile erection, providing evidence that excess adenosine may contribute to priapism. [74][75][76] Theophylline, an adenosine receptor antagonist, has consequently been shown to inhibit these adenosine-induced erections. 74,79 These results suggest the possibility that another signaling pathway may represent a potential target for the future prevention and treatment of priapism.…”

Section: Intracavernosal Injectionsmentioning

confidence: 99%

Medical management of ischemic stuttering priapism: a contemporary review of the literature

Levey¹,

Kutlu²,

Bivalacqua³

2011

Asian J Androl

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Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction (ED). Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease (SCD) and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.

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Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives

Sakhteman

Foroumadi

Sharifzadeh

et al. 2009

Bioorganic & Medicinal Chemistry

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Effects of adenosine analogues on apomorphine-induced penile erection in rats

Cited by 15 publications

References 44 publications

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Medical management of ischemic stuttering priapism: a contemporary review of the literature

Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives

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