1987
DOI: 10.3109/00365528708991895
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Effects of Additional Dietary Gluten on the Small-Intestinal Mucosa of Volunteers and of Patients with Dermatitis Herpetiformis

Abstract: In an attempt to confirm the existence of latent coeliac disease--dose-related gluten-sensitive enteropathy--we have increased dietary gluten by 20 g daily for 2 weeks, in 6 healthy adults and 11 patients with dermatitis herpetiformis (DH). Six of the DH patients had entirely normal jejunal morphology on a normal diet. Jejunal biopsy specimens were taken before and at the end of the study. Measurements of crypts, villi, and crypt mitoses were made on microdissected specimens; disaccharidases were assayed, and … Show more

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Cited by 44 publications
(14 citation statements)
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“…Weinstein (20) first described two patients with dermatitis herpetiformis and normal jejunal biopsies in whom typical coeliac-like enteropathy developed after the addition of extra gluten to their normal diet. This observation has since been confirmed (21,22). There are also several case reports in the literature where an initial normal small bowel biopsy is followed by coeliac disease (23)(24)(25)(26).…”
Section: Latent Coeliac Diseasesupporting
confidence: 55%
“…Weinstein (20) first described two patients with dermatitis herpetiformis and normal jejunal biopsies in whom typical coeliac-like enteropathy developed after the addition of extra gluten to their normal diet. This observation has since been confirmed (21,22). There are also several case reports in the literature where an initial normal small bowel biopsy is followed by coeliac disease (23)(24)(25)(26).…”
Section: Latent Coeliac Diseasesupporting
confidence: 55%
“…One approach to the problem has been to carry out a gluten challenge and demonstrate how much gluten has to be taken before intestinal mucosal inflammation and villous shortening ensue. However, such mainly short‐term studies have yielded somewhat divergent results, 4–7 and they have not been randomized.…”
Section: Introductionmentioning
confidence: 99%
“…In the absence of evidence to the formis [78]. In these patients, inflammation or even overt villous atrophy has ensued after gluten challenge [79]. contrary, we recommend approaching active case finding by screening, and we also treat silent celiac disease cases.…”
Section: Treatment Of Silent and Latent Celiac Diseasementioning
confidence: 99%