Effects of Acute Repetitive Transcranial Magnetic Stimulation on Extracellular Serotonin Concentration in the Rat Prefrontal Cortex

Kanno, Manabu; Matsumoto, Machiko; Togashi, Hiroko; Yoshioka, Mitsuhiro; Mano, Yukio

doi:10.1254/jphs.93.451

Cited by 27 publications

(12 citation statements)

References 42 publications

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“…Previous studies have demonstrated an increase in the responsiveness of the serotonergic system over repeated social interactions (Beitia et al, 2005; Devoino et al, 2003; Filipenko et al, 2002). The stress of being handled and anesthetized in the first experiment could also have contributed to the effect of experience (Levine 1959; Kanno et al 2003). Although the change we observed was relatively small, it raises the possibility that the mice experienced other events prior to our study that could have contributed to inter-individual differences in the responsiveness of their serotonergic systems to social intrusion.…”

Section: Discussionmentioning

confidence: 99%

Social regulation of serotonin in the auditory midbrain.

Hall¹,

Sell²,

Hurley³

2011

Behavioral Neuroscience

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The neuromodulator serotonin regulates auditory processing and can increase within minutes in response to stimuli like broadband noise as well as non-auditory stressors. Little is known about the serotonergic response in the auditory system to more natural stimuli such as social interactions, however. Using carbon-fiber voltammetry, we measured extracellular serotonin in the auditory midbrain of resident male mice during encounters with a male intruder. Serotonin increased in the inferior colliculus (IC) over the course of a 15 minute interaction, but not when mice were separated with a perforated barrier. Several behaviors, including the amount of immobility and anogenital investigation performed by the resident, were correlated with the serotonergic response. Multiple intrinsic factors associated with individual mice also correlated with the serotonergic response. One of these was age: older mice had smaller serotonergic responses to the social interaction. In a second interaction, individual identity predicted serotonergic responses that were highly consistent with those in the first interaction, even when mice were paired with different intruders. Serotonin was also significantly elevated in the second social interaction relative to the first, suggesting a role for social experience. These findings show that during social interaction, serotonin in the IC is influenced by extrinsic factors such as the directness of social interaction and intrinsic factors including age, individual identity, and experience.

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Section: Discussionmentioning

confidence: 99%

Social regulation of serotonin in the auditory midbrain.

Hall¹,

Sell²,

Hurley³

2011

Behavioral Neuroscience

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“…These electrical and transcranial magnetic stimulations have several similar effects on neuronal processes as: modulation of nonlinear ion currents, neuronal membrane potentials, neuronal metabolic (oxidative) processes, neurotransmitters release, etc. (Caramia et al, 1991;Rosenthal and Sick, 1992;You et al, 1998;Juckel et al, 1999;Oliviero et al, 1999;Walsh and Cowey, 2000;Strafella et al, 2001;Kanno et al, 2003;Jelenković et al, 2006).…”

Section: Phosphenes As Electrically or Magnetically Induced Bioluminementioning

confidence: 99%

Phosphene phenomenon: A new concept

Bókkon

2008

Biosystems

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This paper proposes a new biopsychophysical concept of phosphene phenomenon. Namely, visual sensation of phosphenes is due to the intrinsic perception of ultraweak bioluminescent photon emission of cells in the visual system. In other words, phosphenes are bioluminescent biophotons in the visual system induced by various stimuli (mechanical, electrical, magnetic, ionizing radiation, etc.) as well as random bioluminescent biophotons firings of cells in the visual pathway. This biophoton emission can become conscious if induced or spontaneous biophoton emission of cells in the visual system exceeds a distinct threshold. Neuronal biophoton communication can occur by means of non-visual neuronal opsins and natural photosensitive biomolecules. Our interpretation is in direct connection with the functional roles of free radicals and excited biomolecules in living cells.

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“…Associated with this treatment have been reports of changes in several neurotransmitters and neuroactive agents, including dopamine,19–25 catecholamines and other biogenic amines,26–30 serotonin,31,32 gamma-aminobutyric acid (GABA),33–35 hormones,36–38 other chemical moieties,39–48 and interactions among these moieties27–29,40,46 in the brain, blood plasma, and saliva.…”

mentioning

confidence: 99%

Carbonic Anhydrase I, II, and VI, Blood Plasma, Erythrocyte and Saliva Zinc and Copper Increase After Repetitive Transcranial Magnetic Stimulation

Henkin

Potolicchio

Levy

et al. 2010

The American Journal of the Medical Sciences

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Introduction-Repetitive transcranial magnetic stimulation (rTMS) has been used to treat symptoms from many disorders; biochemical changes occurred with this treatment. Preliminary studies with rTMS in patients with taste and smell dysfunction improved sensory function and increased salivary carbonic anhydrase (CA) VI and erythrocyte CA I, II. To obtain more information about these changes after rTMS, we measured changes in several CA enzymes, proteins, and trace metals in their blood plasma, erythrocytes, and saliva.

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Effects of Acute Repetitive Transcranial Magnetic Stimulation on Extracellular Serotonin Concentration in the Rat Prefrontal Cortex

Cited by 27 publications

References 42 publications

Social regulation of serotonin in the auditory midbrain.

Social regulation of serotonin in the auditory midbrain.

Phosphene phenomenon: A new concept

Carbonic Anhydrase I, II, and VI, Blood Plasma, Erythrocyte and Saliva Zinc and Copper Increase After Repetitive Transcranial Magnetic Stimulation

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