Effects of acute-phase response on nutritional status and clinical outcome of hospitalized patients

Gariballa, Salah; Förster, Siegfried

doi:10.1016/j.nut.2006.04.011

Cited by 66 publications

(47 citation statements)

References 18 publications

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“…The serum lysoPLD activity was found to decrease after operation and seemed to re£ect the severity of postoperative damage or the nutritional status; a good correlation was observed between the serum lysoPLD activity and the conventional nutritional status markers (i.e. serum albumin and transthyretin and haemoglobin) 44 after surgery, in both prostate and renal cancer patients. The nutritional markers such as albumin and transthyretin are negative acute phase proteins.We hence checked the correlation between C-reactive protein and lysoPLD activity; the correlation was not statistically signi¢cant, with the r and P values being --0.126 and 0.308, respectively.…”

Section: Discussionmentioning

confidence: 88%

Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Nakamura

Takeuchi²,

Ohkawa

et al. 2007

Ann Clin Biochem

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Section: Discussionmentioning

confidence: 88%

Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Nakamura

Takeuchi²,

Ohkawa

et al. 2007

Ann Clin Biochem

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“…29 It is shown that some anemic celiac patients have high levels of ferritin (an acute phase reactant) and erythrocyte sedimentation rate (ESR), suggestive of systemic inflammation and anemia of chronic disease in these patients. 29,33 …”

Section: Clinical Presentationsmentioning

confidence: 99%

Celiac Disease in the Elderly

Rashtak

Murray

2009

Gastroenterology Clinics of North America

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It has become recently apparent that celiac disease, though once thought to be a primarily childhood disease, can affect people of any age. Epidemiologic studies have suggested that a substantial portion of patients are diagnosed after the age of 50. Indeed, in one study, the median age at the diagnosis was just under the age of 50 with one-third of new patients diagnosed over the age of 65. The purpose of this review is to address the prevalence, clinical features, diagnosis and consequences of celiac disease in the elderly. We will also review management strategies for celiac disease and adjust these with emphasis on the particular nutritional and non-nutritional consequences or associations of celiac disease as they pertain to the elderly.

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“…When utilizing plasma protein for the assessment of protein status, the non-nutritional factors that are known to affect plasma proteins concentration need to be considered. Such factors include biological variation, physiological function, hydration status, patient posture at phlebotomy, hepatic and renal function and the acute phase response [13,14,15,16].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Nutritional Status and Prognosis in Surgical Intensive Care Unit: The Prognostic and Inflammatory Nutritional Index (PINI)

Gharsallah¹

2014

IJNFS

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Background Malnutrition is an independent factor of morbidity and mortality in patients at intensive care unit.The prognostic inflammatory and nutritional index (PINI) is frequently used as a marker of malnutrition but this scoring system was not studied in surgical intensive care units. The purposes of this study were to assist nutritional status with biomarkers and to search for a correlation between biological markers and prognosis, using the PINI. Methods A prospective, observational study was performed in the intensive care unit, started in July 2013. Twenty surgical patients, spent at least seven days at the intensive care unit were enrolled. An early nutritional care was given (first 24 hours). The patients were evaluated each week clinically and biologically (Albumin, Prealbumin, Orosomucoid, C-reactive protein) in order to establish the prognostic inflammatory and nutritional index (PINI = C-reactive protein x Orosomucoid / Albumin x Prealbumin). The correlation between variables was calculated, the Spearman rank-order correlation was used. Results The average age was 56+/-11 years, IGS II score was 48+/-17, APACHE II score was 25+/-12 and MODS ratio was 6+/-4. The mean duration of stay was 40+/-25 days, the mortality rate was 35%. The average calorie intake was 2300+/-600 kcal. There was a weight gain and an increase of the Body Mass Index either in surviving and dead patients. There was an initial increase of the C-reactive protein and the orosomucoid rate during the acute phase of aggression followed by a progressive decrease. The nutritional proteins (albumin, prealbumin, retinol binding protein) were always low, despite a progressive increase. The PINI was initially high and decreased progressively but remained high (> 20).The Albumin and Prealbumin rate were correlated with the MODS ratio. There was a correlation between the orosomucoid rate and the organ failure. The PINI was correlated to the MODS ratio and to the IGS II but not with mortality. Conclusions The malnutrition in surgical patients at intensive care unit has an early onset and is always severe. Biological markers and PINI are correlated with organ failure but not with mortality.

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Effects of acute-phase response on nutritional status and clinical outcome of hospitalized patients

Cited by 66 publications

References 18 publications

Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Celiac Disease in the Elderly

Assessment of Nutritional Status and Prognosis in Surgical Intensive Care Unit: The Prognostic and Inflammatory Nutritional Index (PINI)

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