Effects of acute methamphetamine administration on spacing in paired rats: Investigation with an automated video-analysis method

Shinba, Toshikazu; Yamamoto, Keiji; Cao, Gong-Min; Mugishima, Go; Andow, Yoshinori; Hoshino, Takao

doi:10.1016/0278-5846(96)00082-6

Cited by 15 publications

(7 citation statements)

References 18 publications

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“…Interestingly, in the present study the same phenomenon was also seen in rats given either METH or a MDMA/METH combination. While decreased social interaction during acute METH administration has been reported in rodents (Shinba et al 1996), to our knowledge this is the first report of long term decreases in social interaction following METH administration. Paranoia, anxiety and social withdrawal are well documented phenomena in human METH users (Davidson et al 2001;Rawson et al 2002) and the effects seen here in rats may reflect this phenomenon.…”

Section: Discussionmentioning

confidence: 87%

MDMA (“ecstasy”), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat

Clemens

Nieuwenhuyzen

et al. 2004

Psychopharmacology

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Section: Discussionmentioning

confidence: 87%

MDMA (“ecstasy”), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat

Clemens

Nieuwenhuyzen

et al. 2004

Psychopharmacology

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“…Previous research has shown that acute METH treatment can alter social interaction. For example, Shinba et al 1996 found that rats treated with either 0.1 or 1 mg/kg METH on average spent their time further away from the conspecific in the environment than saline controls [see also (Arakawa 1994)]. Perhaps of more interest from a modeling or simulation perspective is the more recent work by Clemens and colleagues showing ‘social withdrawal’ in rats following an abstinence period from METH (Clemens et al 2007a, b).…”

Section: Animal Modelsmentioning

confidence: 99%

Methamphetamine-Associated Psychosis

Grant

LeVan

Wells

et al. 2011

J Neuroimmune Pharmacol

208

137

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Methamphetamine (METH) is a frequent drug of abuse in U.S. populations and commonly associated with psychosis. This may be a factor in frequent criminal justice referrals and lengthy treatment required by METH users. Persecutory delusions and auditory hallucinations are the most consistent symptoms of METH-associated psychosis (MAP). MAP has largely been studied in Asian populations and risk factors have varied across studies. Duration, frequency and amount of use as well as sexual abuse, family history, other substance use, and co-occurring personality and mood disorders are risk factors for MAP. MAP may be unique with its long duration of psychosis and recurrence without relapse to METH. Seven candidate genes have been identified that may be associated with MAP. Six of these genes are also associated with susceptibility, symptoms, or treatment of schizophrenia and most are linked to glutamatergic neurotransmission. Animal studies of pre-pulse inhibition, attenuation of social interaction, and stereotypy and alterations in locomotion are used to study MAP in rodents. Employing various models, rodent studies have identified neuroanatomical and neurochemical changes associated with METH use. Throughout this review, we identify key gaps in our understanding of MAP and suggest potential directions for future research.

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“…Several substances known to be addictive in humans, such as nicotine, ethanol (EtOH), cocaine, amphetamine, and morphine, also produce drug-seeking behavior in animals as evidenced by the fact that they are self-administered and induce conditioned place preference (CPP) (Reid et al, 1984;McFarland and Ettanberg, 1995;Shaham and Stewart, 1994;Shiba et al, 1996;Masukawa et al, 1993). These drugs preferentially increase extracellular dopamine concentrations and energy metabolism in the shell of the NAc, as estimated by brain microdialysis, in vivo electrochemis-try, and 2-deoxyglucose autoradiography (Pontieri et al, 1996;Di Chiara and Imperato, 1988;Abekawa et al, 1994;Nishijima et al, 1996;Kuczenski et al, 1991;Dewey et al, 1998;Morgan et al, 1997;Yoshimoto et al, 1991;Weiss et al, 1993;Cass, 1996;Sharp, 1987).…”

Section: Introductionmentioning

confidence: 97%

Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine

Gerasimov

Ashby

Gardner

et al. 1999

Synapse

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We examined the acute effect of the irreversible GABA-transaminase inhibitor, gamma-vinyl GABA (GVG, Sabril((R)), Vigabatrin((R))) on increases in nucleus accumbens (NAc) dopamine (DA) following acute administration of methamphetamine, heroin, or ethanol. Methamphetamine (2.5 mg/kg) produced a dose-dependent increase (2, 700%) in NAc DA. GVG preadministration (300 or 600 mg/kg), however, inhibited this response by approximately 39 and 61%, respectively. The lower dose of methamphetamine (1.25 mg/kg), increased DA by 1, 700%. This response was inhibited to a similar extent (44%) regardless of the GVG dose preadministered (300 or 600 mg/kg). In addition, heroin-induced increases in NAc DA (0.5 mg/kg, 170%) were inhibited or completely abolished by GVG (150 or 300 mg/kg, 65 and 100%, respectively). Finally, at half the dose necessary for heroin, GVG (150 mg/kg) also completely abolished ethanol-induced increases in NAc DA following a 0.25 g/kg challenge dose (140%). Taken with our previous findings using nicotine or cocaine as the challenge drug, these results indicate that GVG attenuates increases in NAc DA by a mechanism common to many drugs of abuse. However, it appears unlikely that an acute dose of GVG can completely inhibit increases in NAc DA following challenges with a drug whose mechanism of action is mediated primarily through the DA reuptake site.

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Effects of acute methamphetamine administration on spacing in paired rats: Investigation with an automated video-analysis method

Cited by 15 publications

References 18 publications

MDMA (“ecstasy”), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat

MDMA (“ecstasy”), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat

Methamphetamine-Associated Psychosis

Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine

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