Effects of Acute Hypernatremia on the Electrophysiology of Single Human Ventricular Cardiomyocytes: An In Silico Study
Arie O. Verkerk,
Ronald Wilders
Abstract:Background:
Clinical and experimental data on the cardiac effects of
acute hypernatremia are scarce and inconsistent. We aimed to determine and
understand the effects of different levels of acute hypernatremia on the human
ventricular action potential.
Methods:
We performed computer simulations
using two different, very comprehensive models of the electrical activity of a
single human ventricular cardiomyocyte,
i.e.
, the Tomek–Rodriguez … Show more
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