Effects of acute hormone therapy on recurrent ischemia in postmenopausal women with unstable angina

Abstract

Acute hormone therapy does not reduce ischemia in PMP women with UA when added to standard anti-ischemic therapy.

Postmenopausal hormone replacement therapy and atherosclerosis

“…After 3 years, there was no angiographic difference in disease progression despite significant improvements in lipoprotein levels among estrogen users, and all three treatment groups had similar rates of cardiovascular events and mortality [47•]. Schulman et al [48] randomized postmenopausal women with unstable angina to acute ERT/HRT (intravenous followed by oral CEE ± MPA) or placebo for 21 days and demonstrated no clinical benefit of estrogen in the acute setting.…”

Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia

“…But some studies indicated that HRT did not reduce the overall rate of coronary heart disease (CHD) events in postmenopausal women with established coronary disease. However, the effects of HRT on myocardial repolarization and autonomic tone cannot be excluded [4,5].…”

Exercise and Risk of Breast Cancer

“…The WHI finding that estrogen plus progestin does not confer benefit for preventing CHD among women with a uterus concurs with HERS findings among women with clinically apparent CHD, 10 with the Estrogen Replacement for Atherosclerosis trial, in which estrogen plus progestin did not inhibit progression, 23 and with a trial in women with unstable angina that did not observe a reduction in ischemic events. 24 The finding of an increased risk after initiation of treatment in WHI is similar to HERS. In HERS, after 4.1 and 6.8 years of follow-up, hormone therapy did not increase or decrease risk of cardiovascular events in women with CHD.…”