Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males

Dillon, Katherine N.; Shariffi, Brian; Thompson, Brittany; Steele, Richard; Kim, Jong-Kyung

doi:10.3177/jnsv.66.427

Cited by 4 publications

(5 citation statements)

References 36 publications

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“…One potential explanation contributing to the depressed pressor response to SHE may be due to an improvement in endothelial function via increased production of NO (Kim et al, 2018). This phenomenon has been observed in in human normotensive and prehypertensives during dynamic exercise (Dillon et al, 2020;Shari et al, 2022). Collectively, ndings indicate that GSE supplementation can attenuate BP response to exercise via an increase in vascular conductance.…”

Section: Gse Supplementation During Static Exercisementioning

confidence: 68%

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Apilado,

Boyer,

Gillum

et al. 2024

Preprint

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Studies demonstrated that grape seed extract (GSE) increases the production of nitric oxide (NO) and reduces central sympathetic output. However, limited data have reported regarding the potential beneficial effects of this extract on blood pressure (BP) to increased sympathetic activity induced by the muscle metaboreflex (MMR) activation. Accordingly, the aim of this study was to determine whether GSE supplementation could reduce the BP in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6 ± 3.4 year), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI. MAP was significantly increased during SE and MMR in both conditions, but the rise was significantly attenuated following GSE supplementation compared to PL supplementation (20 ± 2 mmHg vs. 25 ± 2 mmHg). CO was significantly increased during SE and MMR in both conditions, but the rise was significantly higher in GSE treatment than PL treatment. TPR was significantly increased in both conditions, but the rise was significantly higher following PL treatment compared to GSE treatment (SE: 3.1 ± 0.5 mmHg/L/min vs. 0.9 ± 0.6 mmHg/L/min; MMR: 2.7 ± 0.4 mmHg/L/min vs. 1.4 ± 0.4 mmHg/L/min). Our findings suggest that GSE is effective in reducing BP response mediated by the MMR activation. The current study may have potential clinical significance that this extract at least partially buffers an exaggerated BP response evoked during exercise in hypertensive individuals.

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Section: Gse Supplementation During Static Exercisementioning

confidence: 68%

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Apilado,

Boyer,

Gillum

et al. 2024

Preprint

Self Cite

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“…In contrast, an improvement of the vascular health index of heavy smokers after long-term GSE application was described by Weseler et al and suggested to be associated with the induced increase in endogenous antioxidative potential [194]. Furthermore, the overall cardiac output, assessed by impedance cardiography, was improved after the application of a single GSE dose in obese, but not in healthy, participants [202]. ↓ 24 h energy intake (only in subjects with ≥7.5 MJ/day) [197] RCTs are listed according to publication date, whereby 6 RCTs for each group, sorted for highest cohort size (n) of available studies, are provided.…”

Section: Vitis Viniferamentioning

confidence: 90%

“…Regarding the cardiac parameters, the available data obtained from respective RCTs reveal that the long-term GSE treatment of prehypertensive, mild hypertensive, and postmenopausal participants results in decreased systolic and, in some studies, diastolic blood pressure levels [191,[199][200][201]. In two further RCTs, improvements in blood pressure were even measured after a single GSE application in overweight and prehypertensive participants [202,203]. However, no influence of GSE treatment on blood pressure in hypercholesteremia and pre/stage-I hypertensive participants was reported by Ras et al or Preuss et al [196,204].…”

Section: Vitis Viniferamentioning

confidence: 99%

Targeting Metabolic Syndrome in Hidradenitis Suppurativa by Phytochemicals as a Potential Complementary Therapeutic Strategy

Witte,

Wolk,

Witte-Händel

et al. 2023

Nutrients

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by the appearance of painful inflamed nodules, abscesses, and pus-draining sinus tracts in the intertriginous skin of the groins, buttocks, and perianal and axillary regions. Despite its high prevalence of ~0.4–1%, therapeutic options for HS are still limited. Over the past 10 years, it has become clear that HS is a systemic disease, associated with various comorbidities, including metabolic syndrome (MetS) and its sequelae. Accordingly, the life expectancy of HS patients is significantly reduced. MetS, in particular, obesity, can support sustained inflammation and thereby exacerbate skin manifestations and the chronification of HS. However, MetS actually lacks necessary attention in HS therapy, underlining the high medical need for novel therapeutic options. This review directs attention towards the relevance of MetS in HS and evaluates the potential of phytomedical drug candidates to alleviate its components. It starts by describing key facts about HS, the specifics of metabolic alterations in HS patients, and mechanisms by which obesity may exacerbate HS skin alterations. Then, the results from the preclinical studies with phytochemicals on MetS parameters are evaluated and the outcomes of respective randomized controlled clinical trials in healthy people and patients without HS are presented.

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“…Many clinical studies have evaluated the cardioprotective activity of grape. A randomized, double-blind, crossover test revealed that acute grape seed extract supplementation significantly reduced SBP and mean arterial pressure (MAP) in both normal-body-weight males (SBP: 103 ± 4 vs. 99 ± 3 mmHg; MAP: 75 ± 2 vs. 72 ± 2 mmHg) and obese males (SBP: 118 ± 3 vs. 112 ± 5 mmHg; MAP: 86 ± 3 vs. 84 ± 3 mmHg), and the effect in obese males might be associated with a reduction in cardiac output [ 64 ]. However, a systematic review and meta-analysis involving 19 trials based on healthy or unhealthy adults revealed that although grape seed extract supplementation significantly reduced DBP (−2.20 mmHg, 95% confidence interval (CI): −3.79 to −0.60) and heart rate (−1.25 bpm, 95% CI: −2.32 to −0.19), it had no significant effects on flow-mediated dilation (1.02%, 95% CI: −0.62 to 2.66) and SBP (−3.55 mmHg, 95% CI: −7.59 to 0.49) [ 65 ].…”

Section: Health Benefits Of Grapementioning

confidence: 99%

Bioactive Compounds, Health Benefits and Food Applications of Grape

Zhou

Xiong

et al. 2022

Foods

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Grape (Vitis vinifera L.) is one of the most popular fruits worldwide. It contains various bioactive compounds, such as proanthocyanidins, anthocyanins, flavonols, phenolic acids and stilbenes, the contents of which could vary considerably in grape skin, pulp and seed. Many studies have revealed that grape possesses a variety of health benefits, such as antioxidant, anti-inflammatory, gut-microbiota-modulating, anticancer and cardioprotective effects. Grape is eaten as fresh fruit and is also used as raw material to produce various products, such as wine, grape juice and raisins. Moreover, the byproducts of grape, such as grape pomace and grape seed, have many applications in the food industry. In this paper, the bioactive compounds in grape are briefly summarized based on literature published in recent years. In addition, the health benefits of grape and its bioactive components are discussed, with special attention paid to the underlying mechanisms. Furthermore, the applications of grape in the food industry are elucidated, especially the applications of grape pomace and grape seed. This paper can contribute to understanding the health benefits and mechanisms of grape and its bioactive compounds, as well as the promotion of the use of grape in the food industry.

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Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males

Cited by 4 publications

References 36 publications

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Targeting Metabolic Syndrome in Hidradenitis Suppurativa by Phytochemicals as a Potential Complementary Therapeutic Strategy

Bioactive Compounds, Health Benefits and Food Applications of Grape

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