Effects of acute changes in oestrogen on muscle function of the first dorsal interosseus muscle in humans.

Greeves, Julie P.; Cable, N. Timothy; Luckas, Murray; Reilly, Thomas; Biljan, Marinko M

doi:10.1113/jphysiol.1997.sp022016

Cited by 52 publications

(44 citation statements)

References 11 publications

(14 reference statements)

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“…Sarwar et al (1996) reported an increase in fatiguability and a slowing of the half-time of relaxation at mid-cycle (day 12-18), but did not measure hormone concentrations. Greeves et al (1997), however, showed no changes with extreme oestrogen fluctuations, which supports the present findings and confirms the suggestion that oestrogen concentration does not affect skeletal muscle fatiguability and contractile properties.…”

Section: A K Janse De Jonge and Others 164supporting

confidence: 82%

“…There were no significant differences between menstrual cycle phases for any of the variables. Contrary to the work by Phillips et al (1996) and Sarwar et al (1996), Greeves et al (1997) showed in patients undergoing in vitro fertilization that supra-physiological levels of oestrogen did not cause any changes in strength of the first dorsal interosseus muscle. The present study found no changes in strength over the menstrual cycle and did not show a correlation between oestrogen concentration and strength.…”

Section: A K Janse De Jonge and Others 164contrasting

confidence: 52%

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The influence of menstrual cycle phase on skeletal muscle contractile characteristics in humans

Jonge

Boot

Thom

et al. 2001

The Journal of Physiology

180

153

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During their reproductive years the hormone levels in women fluctuate due to the menstrual cycle. The four hormonal markers of the menstrual cycle (oestrogen, progesterone, follicle stimulating hormone (FSH) and luteinising hormone (LH)) change continuously throughout the cycle. These fluctuations in female steroid hormones affect the autonomic nervous system and metabolic functions (Florini, 1987). Therefore certain physiological parameters and athletic performance could change along with the menstrual cycle phases (Becker et al. 1982). However, the influence of the menstrual cycle phase on exercise performance, particularly muscle strength, is unclear. Sarwar et al. (1996) tested skeletal muscle strength, relaxation rate and fatiguability of the quadriceps during the menstrual cycle. They found no changes in these parameters for women taking oral contraceptives. For women not taking oral contraceptives, however, the quadriceps were stronger, more fatiguable and had a longer relaxation time at mid-cycle (day 12-18). Phillips et al. (1996) reported a higher adductor pollicis strength during the follicular phase than during the luteal phase, with a rapid decrease in strength around ovulation. They suggested that oestrogen has a strengthening action on skeletal muscle, although the underlying mechanism is not clear. Greeves et al. (1999), however, reported the highest quadriceps strength during the mid-luteal phase and found a positive relationship between strength and progesterone concentration. Several other studies have found no changes in skeletal muscle strength over the menstrual cycle (DiBrezzo et al. 1991;Quadango et al. 1991;Lebrun et al. 1995;Gür, 1997).The main problem in the measurement of maximum voluntary strength is ensuring that the contraction truly reflects the maximum force-generating capacity of the muscle. Even well-motivated subjects may not always reach full neural activation of their muscles (Rutherford et al. 1986). The extent of neural activation can be evaluated by applying a superimposed electrical stimulus to the muscle during the performance of a maximal voluntary contraction (MVC). When comparing strength over a period of time, such as in menstrual cycle research, it is especially important to ensure maximal neural activation during each test.A further problem encountered in research on the influence of the menstrual cycle on physical performance is the timing of the testing. It is difficult to predict the exact phases of the menstrual cycle and the concurrent reproductive hormone concentrations. Counting days 1. The influence of the different phases of the menstrual cycle on skeletal muscle contractile characteristics was studied in 19 regularly menstruating women. Muscle function was measured when (i) oestrogen and progesterone concentrations were low (menstruation), (ii) oestrogen was elevated and progesterone was low (late follicular phase), and (iii) oestrogen and progesterone were both elevated (luteal phase).2. Maximal isometric quadriceps strength, fatiguability and electrica...

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Section: A K Janse De Jonge and Others 164supporting

confidence: 82%

Section: A K Janse De Jonge and Others 164contrasting

confidence: 52%

The influence of menstrual cycle phase on skeletal muscle contractile characteristics in humans

Jonge

Boot

Thom

et al. 2001

The Journal of Physiology

180

153

View full text Add to dashboard Cite

show abstract

“…A long-term treatment of the developing rat with estrogen reduced the tetanus tension of skeletal muscle [7]. In women, the supplement with a supraphysiological level of estrogen did not affect the contractile force and fatigue process of the first dorsal interosseus muscle [8]. Neither did the administration of estrogen significantly affect the fatigue of the estradiol-injected extensor digitorum longus muscle in rat [9].…”

mentioning

confidence: 93%

Effects of 17.BETA.-Estradiol on Tension Responses and Fatigue in the Skeletal Twitch Muscle Fibers of Frog.

Hatae

2001

JJP

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Estrogens, like other steroid hormones, initiate their action via specific intracellular receptors [1]. The presence of estrogen receptors in the skeletal muscle cell was demonstrated in bovine [2], rabbit [3,4], and rat [5]. Skeletal myoblasts also expressed functional estrogen receptors [6]. The effects of estrogen on skeletal muscle contractility have been diversely reported. A long-term treatment of the developing rat with estrogen reduced the tetanus tension of skeletal muscle [7]. In women, the supplement with a supraphysiological level of estrogen did not affect the contractile force and fatigue process of the first dorsal interosseus muscle [8]. Neither did the administration of estrogen significantly affect the fatigue of the estradiol-injected extensor digitorum longus muscle in rat [9]. In frog skeletal muscle, however, Rana temporaria, the presence of diethyl-stilboesterol, a nonsteroidal estrogen, markedly potentiated the twitch tension, but apparently not the tetanus tension [10], and it also potentiated the tension response of the fatigued Key words: skeletal muscle, contraction, fatigue, 17␤-estradiol. Abstract:The effects of 17␤-estradiol (10an active estrogen, on the tension and fatigue responses of single fiber or fiber bundle prepared from frog skeletal muscle were investigated. The administration of 17␤-estradiol caused a transient potentiation of tetanus tension by field stimulation at every minute. This potentiation was not affected by the presence of nicardipine, suggesting that the action of 17␤-estradiol would place the excitation-contraction (E-C) coupling beyond T-tubule depolarization. Fatigue was produced by repeated tetanic stimulation every second until tension declined to approximately 40% of the initial level. Fibers were then allowed to recover by having tetani given to them every minute. In the normal Ringer solution, the time to 50% of the initial tetanus tension was 41.7 s.With the presence of 17␤-estradiol, the time to 50% tension was faster than that of control. The presence of 17␣-estradiol, a stereoisomer, caused no potentiation of tetanic tension to be stimulated every minute, and the rate of decline of fatigued response was almost the same as that of control, suggesting the existence of specific estrogen receptors in the frog muscle. In fatigued muscle with or without estrogen, the tension to field stimulation was transient and not sustained. When the fatigued muscle was again treated with field stimulation at every minute after the more-frequent stimulation, the recovery rate was increased in 17␤-estradiol. A prompt reduction in temperature to 5°C, from 20°C, in the presence of caffeine elicited the tension response, a rapid cooling contracture (RCC). The presence of 17␤-estradiol inhibited peak tension and maximum rate of rise of the RCC only after the repetitive electrical stimuli. These results suggest that the potentiation of contraction upon the electrical stimulation by 17␤-estradiol was induced by the increase of myoplasmic-free Ca 2ϩ concentration via an activ...

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“…Researchers used various models of reproductive functioning to investigate this relationship including; the menstrual cycle 6 , the menopause 7 , in vitro fertilisation (IVF) treatment 8 , pregnancy 9 , oral contraceptives 10 (OC's) and hormone replacement therapies 11 (HRT's). Since then, numerous review papers [12][13][14] have been published, yet the number of original research outputs has declined.…”

Section: Introductionmentioning

confidence: 99%

The relationship between oestrogen and muscle strength: a current perspective

Elliott‐Sale

2014

Rev. bras. educ. fís. esporte

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The relationship between muscle strength and oestrogen is ambiguous and is still largely unresolved. The evidence for and against an effect of oestradiol on determinants of muscle function is equivocal and often contradictory. The bulk of the research in this area was performed during the eighties and nineties, using models of reproductive functioning such as; the menstrual cycle, the menopause and hormone replacement therapy, oral contraceptives and in vitro fertilisation treatment, to alter the female hormonal milieu. In the last decade, approximately 15 papers have demonstrated a relationship, both positive and negative, between the concentration of oestrogen and skeletal muscle strength. Conversely, around 20 articles have not shown any infl uence of oestrogen on a number of strength measures. The majority of these studies were performed using post-menopausal and eumenorrheic females. Most current studies use hormonal assays to confi rm oestrogen status, however no recent studies have reported the bioavailable concentration of oestradiol. Similarly, no research in the last 10 years has used in vitro fertilisation treatment or pregnancy as acute and chronic models of supra-physiological changes in sex hormone concentration. Future work should focus on performing meta-analyses on each of the key components of muscle strength in an attempt to elucidate a causal relationship. In addition, models of reproductive functioning that cause the greatest magnitude of change to oestrogen concentration should be used, while controlling as many confounding factors as possible.

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Effects of acute changes in oestrogen on muscle function of the first dorsal interosseus muscle in humans.

Cited by 52 publications

References 11 publications

The influence of menstrual cycle phase on skeletal muscle contractile characteristics in humans

The influence of menstrual cycle phase on skeletal muscle contractile characteristics in humans

Effects of 17.BETA.-Estradiol on Tension Responses and Fatigue in the Skeletal Twitch Muscle Fibers of Frog.

The relationship between oestrogen and muscle strength: a current perspective

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