Effects of acute and subchronic Delta 9-tetrahydrocannabinol administration on the plasma catecholamine, beta-endorphin, and corticosterone levels and splenic natural killer cell activity in rats

Patel, Vandana; Borysenko, Myrin; Kumar, M; Wj, Millard

doi:10.1016/0378-8741(86)90126-1

Cited by 5 publications

(4 citation statements)

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“…Systemic injections of delta(9)-tetrahydrocannabinol (THC, the main psychoactive component of marijuana) do not alter HPA activity on its own and subchronic THC seems to decrease HPA activity [192]. This may be due, in part, to peripheral effects, as centrally administered THC (intracerebroventricular injections) leads to a marked increase in plasma ACTH and CORT at multiple doses [193].…”

Section: Preclinical Studies Of Drug Administration and Stress Responmentioning

confidence: 99%

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Fosnocht

Briand

2016

Physiology & Behavior

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Drug addiction is a major public health concern in the United States costing taxpayers billions in health care costs, lost productivity and law enforcement. However, the availability of effective treatment options remains limited. The development of novel therapeutics will not be possible without a better understanding of the addicted brain. Studies in both clinical and preclinical models indicate that chronic drug use leads to alterations in the body and brain’s response to stress. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis may shed light on the ability of stress to increase vulnerability to relapse. Further, within both the HPA axis and limbic brain regions, corticotropin-releasing factor (CRF) is critically involved in the brain’s response to stress. Alterations in both central and peripheral CRF activity seen following chronic drug use provide a mechanism by which substance use can alter stress reactivity, thus mediating addictive phenotypes. While many reviews have focused on how stress alters drug-mediated changes in physiology and behavior, the goal of this review is to focus on how substance use alters responses to stress.

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Section: Preclinical Studies Of Drug Administration and Stress Responmentioning

confidence: 99%

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Fosnocht

Briand

2016

Physiology & Behavior

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“…In vitro studies on human NK cells demonstrated that cannabinoids can inhibit the constitutive expression of chemokines, IL-8, MIP1-α, MIP-1β, RANTES, phorbol ester stimulated TNF-α, GM-CSF and IFN-gamma. Studies have demonstrated that cannabinoids can suppress NK cell function such as cytolytic activity in rats, mice and humans, which is a cannabinoid receptor-dependent process [75–77]. …”

Section: Natural Killer Cells and Neutrophilsmentioning

confidence: 99%

Endocannabinoids and immune regulation☆

Pandey

Mousawy

Nagarkatti

2009

Pharmacological Research

176

122

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Cannabinoid pharmacology has made important advances in recent years after the discovery of the cannabinoid receptors. These discoveries have added to our understanding of exogenous and endogenous cannabinoid signaling along with exploring the various pathways of their biosynthesis, molecular structure, inactivation, and anatomical distribution of their receptors throughout the body. The endocannabinoid system is involved in immunoregulation and neuroprotection. In this article, we have reviewed the possible mechanisms of the regulation of the immune response by endocannabinoids which include modulation of immune response in different cell types, effect on cytokine network, induction of apoptosis in immune cells and downregulation of innate and adaptive immune response. Studies from our laboratory have suggested that administration of endocannabinoids or use of inhibitors of enzymes that breakdown the endocannabinoids, leads to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Thus, manipulation of endocannabinoids in vivo may constitute a novel treatment modality against inflammatory disorders.

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“…Another plausible modality for removing NK inhibitory signals in vivo may be via the modulation of endocannabinoid signaling. Clues for the involvement of endocannabinoids in cancer propagation are evident: the selective inhibition of NK cells by delta-9-tetrahydrocannabinol and marijuana was documented already in the 1980 s [Patel et al, 1985;Specter et al, 1986Specter et al, , 1989Kawakami et al, 1988]. A more recent clue for the anti-cancer potential of augmenting endocannabinoid signaling comes from a demonstration that NK migration is stimulated by the endocannabinoids 2-arachidonoylglycerol, an effect that was blocked by delta-9-tetrahydrocannabinol [Kishimoto et al, 2005].…”

Section: An Endocannabinoid Connection?mentioning

confidence: 95%

Cancer therapeutics: reflections on natural killer cells

Genevieve

2008

Drug Development Research

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Cancer remains a leading cause of death globally, including in developing countries. In spite of the introduction of several new drugs to the anti-cancer arsenal in recent years, including monoclonal antibodies and selective tyrosine kinase inhibitors blocking the action of cancer-promoting hormones, full remission remains exceptional in many common cancers including lung, pancreas, and stomach cancers. One aspect of cancer therapeutics that remains mostly neglected is developing drugs for promoting the capacity of the innate immune system, most notably the natural killer cells, to recognize and destroy cancer cells. Minimizing the inhibition of natural killer cells' cytotoxic activity by current cancer therapeutics also deserves further consideration in cancer research. Better understanding of the physiology of the immune cells, in particular of factors regulating the action and differentiation of natural killer cells and their migration into tumor tissues, seems worthy of more in-depth research toward developing new cancer drugs. In this context, the potential of selective cannabinoid receptor agonists and fatty acid amid hydrolase inhibitors as immune-enhancing drugs deserves extra attention. Drug Dev Res 69 : 285-288, 2008.

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Effects of acute and subchronic Delta 9-tetrahydrocannabinol administration on the plasma catecholamine, beta-endorphin, and corticosterone levels and splenic natural killer cell activity in rats

Cited by 5 publications

References 0 publications

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Endocannabinoids and immune regulation☆

Cancer therapeutics: reflections on natural killer cells

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