Effects of Acute and Sub-acute Oral Toxicity Studies of Ethanol Extract of Tanacetum parthenium (L) Sch. Bip. Aerial Parts in Mice and Rats

Enciso-Roca, Edwin; Aguilar-Felices, Enrique Javier; Tinco-Jayo, J.A.; Arroyo-Acevedo, Jorge Luis; Herrera-Calderon, Oscar; Aguilar-Carranza, Cristian; Justil-Guerrero, Hugo

doi:10.9734/arrb/2017/37326

Cited by 3 publications

(4 citation statements)

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“…In the phytochemical study, the ethanolic extract of flowers and leaves presented similar secondary metabolites. The secondary metabolites determined in the present study are related to the results reported by Enciso et al 8 In the in vitro antioxidant capacity assay against the DPPH radical, the ethanolic of flower extract had a high antioxidant capacity than the leaf extract, which shows that the in vitro antioxidant activity, however the extracts did not exceed the standard antioxidant Trolox. Since the most representative metabolite are triterpenes and steroids, according to Jain et al, 10 polyphenols are also recognized for their property as free radical scavengers due to their property of donating electrons, their antioxidant activity depends on the stability of different systems as well as on the number and the location of hydroxyl groups.…”

Section: Discussionsupporting

confidence: 88%

“…Traditionally is used for digestive problems such as diarrhea, abdominal pain, and other like migraine and mountain disease. 8 The extract of this plant has revealed the presence of sesquiterpene lactone like parthenolides and various phenolic compounds. The main metabolite isolated in T. parthenium named parthenolide presented analgesic effect after sciatic nerve injury.…”

Section: Introductionmentioning

confidence: 99%

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Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model

Herrera-Calderon,

Bulege-Gutiérrez,

Javier-Silva

et al. 2023

Pharmacogn J.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model

Herrera-Calderon,

Bulege-Gutiérrez,

Javier-Silva

et al. 2023

Pharmacogn J.

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“…Although some authors have reported [ 51 , 52 , 53 ] that large doses of essential oil induce convulsions, there has been no systematic evaluation of the toxic effects of T. parthenium . Our investigation showed that the essential oil of the Bulgarian population of Tanacetum parthenium is nontoxic when administered to rats as a single oral dose and moderately toxic when administered as a single dose via the intraperitoneal route.…”

Section: Resultsmentioning

confidence: 99%

A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil

Lechkova,

Karcheva-Bahchevanska,

Ivanov

et al. 2023

Molecules

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Background: Tanacetum parthenium (L.) Sch.Bip. (T. parthenium) is an aromatic perennial plant belonging to the Asteraceae family, also known as feverfew. It is widely distributed in various regions of Europe and other parts of the world. The plant has a rich background in the traditional medicine of many nations and has been used as a remedy for fever, pain, inflammation, asthma, rheumatism, menstrual disorders, etc. Methods: GC–MS analysis was conducted to determine the chemical composition of the isolated essential oil (EO). Using the method proposed by Litchfield and Wilcoxon, the average lethal dose (LD50) of the EO on Wistar rats was determined for two routes of administration: oral (p.o.) and intraperitoneal (i.p.). The subacute toxicity of the EO was also tested by oral administration of a daily dose of 1.0 g/kg body weight (BW) for 28 days. The toxicity of the EO was evaluated by observing and evaluating changes in behavior, body weight, basic hematological and serum biochemical parameters, and histopathological changes of the internal organs. Results: Thirty-seven volatile organic compounds representing 94.58% of the total oil composition were tentatively detected in the obtained T. parthenium EO. The dominant compounds were camphor (45.47%), trans-chrisantenyl acetate (21.65%), camphene (9.48%), and cis-isogeraniol (5.42%). The results showed that the EO was not toxic when administered in acute oral doses. The acute mean lethal dose for intraperitoneal administration was LD50 i.p. = 2.13 g/kg BW. In the subacute study involving administration of an oral dose of EO for 28 days, there were a number of changes in the hematological and serum biochemical parameters of the blood compared with the control group of animals. However, no symptoms of toxicity, changes in the body weight of the rats, death, or pathological changes in the histological indicators of the examined organs—brain, heart, stomach, liver, spleen and kidney—were found. Extrapolating the results obtained from the rat experiments, we can state that the EO is safe for use in doses below 1 g/kgBW for a period not exceeding one month.

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“…The sheets were assembled with coverslips and Entellan ® (Sigma Chemical Co, St. Louis, MO, USA), which is a rapid non-aqueous mounting medium. Finally, the organ slides were examined microscopically and photographed with an optical microscope Nikon Eclipse E200 (Shinagawa Intercity Tower C, 2-15-3, Konan, Minato-ku, Tokyo 108-6290, Japan) at 40× and 200× magnification [14].…”

Section: Histopathological Analysismentioning

confidence: 99%

TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes

Velasco-Chong

Herrera-Calderón

Rojas-Armas

et al. 2020

Foods

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Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.

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Effects of Acute and Sub-acute Oral Toxicity Studies of Ethanol Extract of Tanacetum parthenium (L) Sch. Bip. Aerial Parts in Mice and Rats

Cited by 3 publications

References 0 publications

Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model

Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model

A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil

TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes

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