Effects of Acute and Long-Term Domperidone Treatment on Prolactin and Gonadal Hormone Levels and Sexual Behavior of Male and Female Rats

Nasello, Antonia G.; Vanzeler, Maria Luzinete Alves; Madureira, Ed Hoffmann; Felício, Luciano Freitas

doi:10.1016/s0091-3057(97)00322-5

Cited by 30 publications

(22 citation statements)

References 39 publications

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“…Furthermore, the increase in testosterone causes a reduction in serum ACTH levels (16), while testosterone injections in intact male rats inhibit ACTH secretion (28). Long-term A B hyperprolactinemia (i.e., 30 days) results in a decrease in serum testosterone levels in adult male rats (29,30). PRL stimulates the activity of 5 α-reductase leading to a decrease in testosterone production.…”

Section: Discussionmentioning

confidence: 99%

Prolactin induces adrenal hypertrophy

Silva

Felício

Nasello

et al. 2004

Braz J Med Biol Res

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Although adrenocorticotropic hormone is generally considered to play a major role in the regulation of adrenal glucocorticoid secretion, several reports have suggested that other pituitary hormones (e.g., prolactin) also play a significant role in the regulation of adrenal function. The aim of the present study was to measure the adrenocortical cell area and to determine the effects of the transition from the prepubertal to the postpubertal period on the hyperprolactinemic state induced by domperidone (4.0 mg kg -1 day -1 , sc). In hyperprolactinemic adult and young rats, the adrenals were heavier, as determined at necropsy, than in the respective controls: adults (30 days: 0.16 ± 0.008 and 0.11 ± 0.007; 46 days: 0.17 ± 0.006 and 0.12 ± 0.008, and 61 days: 0.17 ± 0.008 and 0.10 ± 0.004 mg for treated and control animals, respectively; P < 0.05), and young rats (30 days: 0.19 ± 0.003 and 0.16 ± 0.007, and 60 days: 0.16 ± 0.006 and 0.13 ± 0.009 mg; P < 0.05). We selected randomly a circular area in which we counted the nuclei of adrenocortical cells. The area of zona fasciculata cells was increased in hyperprolactinemic adult and young rats compared to controls: adults: (61 days: 524.90 ± 47.85 and 244.84 ± 9.03 µm 2 for treated and control animals, respectively; P < 0.05), and young rats: (15 days: 462.30 ± 16.24 and 414.28 ± 18.19; 60 days: 640.51 ± 12.91 and 480.24 ± 22.79 µm 2 ; P < 0.05). Based on these data we conclude that the increase in adrenal weight observed in the hyperprolactinemic animals may be due to prolactin-induced adrenocortical cell hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Prolactin induces adrenal hypertrophy

Silva

Felício

Nasello

et al. 2004

Braz J Med Biol Res

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“…Previous works have demonstrated that treatment with domperidone (DOMP, 4.0 mg.kg ) was able to increase PRL secretion and this effect lasted for about 72 hours BRIDGES, 1992;NASELLO et al, 1995;NASELLO et al, 1997;SILVA et al, 2004). A total of 139 male Wistar rats from the colony of the FMVZ/USP were used: 68 young (45 ± 5 days old) and 71 adult rats (75 ± 5 days old) in order to evaluate the effects of DOMP-induced hyperprolactinemia on the induction of prostatic inflammation.…”

Section: Methodsmentioning

confidence: 99%

“…It has been established that PRL stimulates prostate growth and functioning in both young and adult rats (KEENAN; KLASE; THOMAS, 1981; NEGRO-VILAR; KRULICH; McCANN, 1973;LEE, 1983). Moreover, inflammation in lateral prostate seems to be related to high serum PRL levels (STOKER;COOPER, 1999).…”

Section: Introductionmentioning

confidence: 99%

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O papel da prolactina na inflamação prostática

Silva

Zaidan-Dagli

Nasello

et al. 2013

Braz. J. Vet. Res. Anim. Sci.

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Coppenolle et al. (2001) reported hyperprolactinemia induced hyperplasia associated with inflammation in the rat lateral prostate lobe after treatments for 30 and 60 days with sulpiride.The period prior to rat puberty, from the 15 th to the 25 th postnatal day, has been acknowledged as being critical to prostatic development. In this period, plasma PRL levels begin to rise, reaching the highest point on the 25 th day of postnatal development (NEGRO-

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“…Foi proposto que a presença de altos níveis de prolactina nas ratas lactantes estaria associada a esta atenuação uma vez que a prolactina tem efeitos supressivos na inflamação (SUGIURA et al, 2012;NASCIMENTO et al, 2013;OCHOA-AMAYA et al, 2015). Para investigar essa hipótese, neste trabalho, ratas virgens foram tratadas com domperidona por 5 dias, um esquema de tratamento que promove hiperprolactinemia (NASELLO et al, 1997;OCHOA-AMAYA et al, 2010 LENCZOWSKI et al, 1999).…”

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<b>Influência do LPS e do zinco na interação mãe e filhote</b>

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Effects of Acute and Long-Term Domperidone Treatment on Prolactin and Gonadal Hormone Levels and Sexual Behavior of Male and Female Rats

Cited by 30 publications

References 39 publications

Prolactin induces adrenal hypertrophy

Prolactin induces adrenal hypertrophy

O papel da prolactina na inflamação prostática

<b>Influência do LPS e do zinco na interação mãe e filhote</b>

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