Effects of acute and chronic exposure to natural sunlight and UVB on CD4/CD8 ratio and circulating pro-inflammatory and anti-inflammatory cytokine levels in mice

Omer, Saida Abd Elkreem; Badi, Rehab M.; Garelnabi, Mohamed Elfadil Mohamed; Altayeb, Osama Ahmed; Hussein, Mohammed Osman; Fadul, Eman Abbass; Saeed, Amal M.

doi:10.1016/j.sciaf.2019.e00102

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…It is known, that photons of UV radiation (especially UVA) penetrate deep into the dermis and have the ability to directly affect blood and lymph vessels [ 55 ]. UVB radiation, on the other hand, is responsible for many direct photochemical changes and is known to stimulate skin cells to release cytokines (and other signaling molecules) directly into the blood [ 56 ]. Moreover, both UVA radiation and UVB radiation cause overproduction of ROS in skin cells, which leads to oxidative stress resulting in oxidative modifications of DNA, proteins and lipids [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol

et al. 2021

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UVA/UVB radiation disturbs the redox balance of skin cells, and metabolic consequences can be transferred into the blood and internal tissues, especially after chronic skin exposure to UV radiation. Therefore, the aim of this study was to evaluate the effect of cannabidiol (CBD), an antioxidant and anti-inflammatory phytocannabinoid, on oxidative stress and its consequences in the blood of nude rats whose skin was exposed to UVA/UVB radiation for 4 weeks. It was shown that CBD penetrated the blood and in UVB-irradiated rats was preferentially located in the membranes of polymorphonuclear leukocytes, which promoted reduction of ROS generation and up-regulation of antioxidant ability by increasing the activity of glutathione reductase and thioredoxin reductase, while the level of reduced glutathione decreased by UV radiation. Consequently, reduction in UV-induced lipid peroxidation, assessed as 4-hydroxynonenal (4-HNE) and 8-isoprostane (8-isoPGF2α) as well as protein modifications, estimated as 4-HNE-protein adducts and protein carbonyl groups, was observed. CBD, by countering the UV-induced down-regulation of 2-arachidonylglycerol, promoted its antioxidant/anti-inflammatory effects by reducing CB1 and increasing PPARγ receptor activation and consequently ROS and TNF-α down-regulation. The results suggest that CBD applied topically to the skin minimizes redox changes not only at the skin level, but also at the systemic level.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol

et al. 2021

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“…Based on the results of statistical tests, the p value of 0.550 (> 0.05) means that there is no difference in each treatment group. A similar study was also conducted by Omer et al, 2019 which stated that there was no difference in IL-10 levels in exposure to ultraviolet sunlight from 11 to 12 noon with a duration of 30 minutes for 14 days in experimental animals. A similar study was also conducted by Narbutt et al, 2005 no significant changes in IL-10 were found and its cytokine level was detected before irradiation in single subjects only.…”

Section: Discussionmentioning

confidence: 62%

The Effect Of Various Sun Time Under Exposure To Ultraviolet Light Of The Sun On Interleukin 10 Cytokine

Kuncara

2022

JBP

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Sunbathing activities are often found to occur during the severe acute respiratory syndrome coronavirus 2 (SARS CoV2) pandemic that causes Corona Virus Disease 2019 (COVID 19). IL-10 is an inhibitory cytokine for macrophages and dendritic cells that play a role in controlling non-specific and cellular immune reactions. The purpose of this study was to explain the immunosuppression by the cytokine interleukin 10 which is often found to occur due to sun exposure. This research method is an experimental study with a completely randomized design (CRD). The research design used was a randomized post test only control group design. Data were analyzed using the Kruskal Wallis test with statistical test results obtained p value 0.550 (> 0.05) meaning there was no difference in the levels of cytokine interleukin 10 in each treatment group.

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“…Even though the exposure dose is low, emerging skin diseases caused by chronic UVB exposure have some similarities to acute exposure. Omer et al [ 30 ] demonstrated that the chronic low-dose UVB exposure is related to acute and chronic inflammation mediated through cytokine and immune pathways. However, Grivennikov et al [ 31 ] described the effects of inflammation and immune response on cancer.…”

Section: Adverse Pathogenic Effects Of Uvb Exposurementioning

confidence: 99%

A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer

et al. 2022

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As a principal component of solar radiation, ultraviolet B (UVB) exposure can be harmful depending on the duration and intensity because the human body can easily be exposed to it. Many studies have demonstrated that UVB causes a series of inflammatory and other skin disorders. UVB has been classified as the Group 1 carcinogen by the International Agency for Research on Cancer. Diverse studies have focused on UVB exposure but the complex perspective of acute and chronic UVB exposure is still lacking. This review presents the differences between acute and chronic exposure to UVB and summarizes public information in terms of toxicogenomic characteristics. We also demonstrated the differences between adverse effects of acute and chronic UVB exposure on the skin system. From the published literatures, we compared the biological pathways predict of the adverse effects caused by each UVB exposure type. Furthermore, our review not only clarifies the differences in each UVB exposure network but also suggests major hub genes related to cellular mechanisms and diseases that are thought to be affected by acute and chronic UVB exposure.

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Effects of acute and chronic exposure to natural sunlight and UVB on CD4/CD8 ratio and circulating pro-inflammatory and anti-inflammatory cytokine levels in mice

Cited by 5 publications

References 30 publications

Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol

Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol

The Effect Of Various Sun Time Under Exposure To Ultraviolet Light Of The Sun On Interleukin 10 Cytokine

A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer

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