Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test

Kelliher, Padraig; Kelly, John; Leonard, Brian E.; Sanchéz, Connie

doi:10.1016/s0306-4530(02)00026-4

Cited by 30 publications

(13 citation statements)

References 53 publications

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“…Temporal specificity of antidepressant behavioral effects in the FST have also been reported in C57Bl/6 mice treated with chronic amitriptyline (21 days, via drinking water) (Caldarone et al, 2003), and in rats treated with fluoxetine via osmotic minipumps (Cryan et al, 2005). However, repeated treatment by daily injection (Reneric et al, 2002) or gavage (Kelliher et al, 2003) in rats showed no difference in the behavioral effects with chronic treatment, although this may be a consequence of the doses studied (Detke et al, 1997).…”

Section: Introductionmentioning

confidence: 75%

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick

Lee

Hen

et al. 2007

Neuropsychopharmacol

277

206

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We previously reported that chronic, but not subchronic, treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine altered behavior in the forced swimming test (FST) in BALB/cJ mice. We now use this model to investigate mechanisms underlying the delayed onset of the behavioral response to antidepressants, specifically (1) adult hippocampal neurogenesis and (2) expression of the 5-HT1A receptor. Here, we show data validating this model of chronic antidepressant action. We found the FST to be selectively responsive to chronic administration of the SSRI fluoxetine (18 mg/kg/day) and the tricyclic antidepressant desipramine (20 mg/kg/day), but not to the antipsychotic haloperidol (1 mg/kg/day) in BALB/cJ mice. The behavioral effects of fluoxetine emerged by 12 days of treatment, and were affected neither by ablation of progenitor cells of the hippocampus nor by genetic deletion of the 5-HT1A receptor. The effect of fluoxetine in the BALB/cJ mice was also neurogenesis-independent in the novelty-induced hypophagia test. We also found that chronic fluoxetine does not induce an increase in cell proliferation or the number of young neurons as measured by BrdU and doublecortin immunolabeling, respectively, in BALB/cJ mice. These data are in contrast to our previous report using a different strain of mice (129SvEvTac). In conclusion, we find that BALB/cJ mice show a robust response to chronic SSRI treatment in the FST, which is not mediated by an increase in new neurons in the hippocampus, and does not require the 5-HT1A receptor. These findings suggest that SSRIs can produce antidepressant-like effects via distinct mechanisms in different mouse strains.

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Section: Introductionmentioning

confidence: 75%

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick

Lee

Hen

et al. 2007

Neuropsychopharmacol

277

206

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“…However, acute antidepressant-like effects in the forced swim test are likely to reflect the initial events elicited by antidepressants rather than the progressive changes that are likely to accompany chronic antidepressant treatment. Studies comparing the acute and chronic effects of SSRIs in the forced swim test have reported comparable behavioral effects at the two timepoints both in rats (Reneric et al, 2002;Kelliher et al, 2003) and in mice (Conti et al, 2002). In addition, C57BL/6 mice have been shown to be sensitive to chronic treatment with tricyclic antidepressants in the forced swim test, although acute or subchronic timepoints were not evaluated (Alcaro et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression

Dulawa

Holick

Gundersen

et al. 2004

Neuropsychopharmacol

607

485

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The onset of the therapeutic response to antidepressant treatment exhibits a characteristic delay. Animal models sensitive to chronic, but not acute, antidepressant treatment are greatly needed for studying antidepressant mechanisms. We initially assessed four inbred mouse strains for their behavioral response to chronic treatment with the selective-serotonin reuptake inhibitor fluoxetine (0, 5, 10 mg/kg/day in drinking water), which is used for the treatment of mood and anxiety disorders. Only the highly anxious BALB/c strain exhibited sensitivity to fluoxetine in the forced swim test. Additionally, fluoxetine reduced locomotion in C57BL/6 and 129SvEv, but not BALB/c and DBA/2, strains. We then evaluated the effects of subchronic (B4 days) and chronic (B24 days) fluoxetine treatment (0, 10, 18, 25 mg/kg/day) on measures of anxiety and depression in BALB/c mice. Anxiety measures were obtained using the open field and noveltyinduced hypophagia tests. Antidepressant effects were evaluated using the forced swim test. We found 18 mg/kg/day of chronic fluoxetine to be active in all three paradigms; subchronic treatment had no effect. Anxiety-related measures were reduced by 18 mg/kg/ day. In the forced swim test, 10 and 18 mg/kg/day increased swimming and reduced immobility. Here we present several novel effects of chronic, but not subchronic, antidepressant treatment.

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“…Although antidepressants produce effects in the rat FST following either short-term or chronic treatment, it is uncertain whether antidepressants might produce different behavioral changes following chronic treatments compared to short-term effects (Caldarone et al 2003;Dulawa et al 2004;Kelliher et al 2003;Reneric et al 2002). Chronic treatment is known to increase sensitivity to the behavioral effects of antidepressants in the FST, so that doses that were without effect following acute treatment produced antidepressant-like effects upon sustained treatment for 14 days (Detke et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment

2005

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Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test

Cited by 30 publications

References 53 publications

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression

Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment

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