Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients

Systematic Review and Meta-Analysis of Circulating Irisin Levels Following Endurance Training: Results of Continuous and Interval Training

“…The literature search and selection of studies are presented in Figure 1. Inclusion criteria for continuous endurance training were fulfilled by 12 articles (Daskalopoulou et al, 2014; Dror et al, 2022; Ercan et al, 2022; He et al, 2019; Norheim et al, 2014; Ozbay et al, 2020; Qiu et al, 2018; Tsai et al, 2021; Tsuchiya et al, 2014; 2015; Ugras et al, 2022; Ulupinar et al, 2021), resulting in 15 individual treatment effects because of many group comparisons. Ozbay et al, 2020; Qiu et al, 2018; and Ugras et al, 2022 each resulted in 2 estimated effects corresponding to 2 experimental groups that received the same intervention (Table 1).…”

“…All sessions durations ranged between 30 minutes and 50 minutes, with the exceptions which lasted 60 minutes (Tsuchiya et al, 2015), 24 minutes (Tsai et al, 2021), 20 minutes (Tsuchiya et al, 2014) and 10 minutes (Daskalopoulou et al, 2014). Regarding training intensity, articles used mainly 2 intensity scales: percentage of maximal oxygen consumption (VO 2 max) (Daskalopoulou et al, 2014; He et al, 2019; Norheim et al, 2014; Qiu et al, 2018; Tsuchiya et al, 2014; 2015) and percentage of maximum heart rate (HR max ) (Ercan et al, 2022; Ozbay et al, 2020; Ugras et al, 2022; Ulupinar et al, 2021). Intensities ranged between 52%-85% VO 2 max and 64–76% HR max , which in general terms, indicates moderate intensity training.…”

“…All included articles measured circulating irisin, either in plasma or serum, using commercially available ELISA kits. Phoenix Pharmaceuticals Inc was the most used manufacturer in the included studies, using their first (Daskalopoulou et al, 2014; Norheim et al, 2014; Qiu et al, 2018; Tsuchiya et al, 2014; 2015), second (Dror et al, 2022; He et al, 2018; 2019; Lagzdina et al, 2020; Nygaard et al, 2015) or third (Tsai et al, 2021) generation kits, although Shanghai Sunred Biological Technology Co. Ltd #201–12-5328 kit (Ozbay et al, 2020; Ulupinar et al, 2021) or Elabscience Biotechnology Co. Ltd #E-EL-H6120 were also used (Eken & Kafkas, 2022; Ercan et al, 2022). Regarding measurements, all articles measured circulating irisin at baseline and after the end of training, in a range from immediately after (Dror et al, 2022; Eken & Kafkas, 2022; Ercan et al, 2022; He et al, 2018; 2019; Norheim et al, 2014; Nygaard et al, 2015; Ozbay et al, 2020; Tsuchiya et al, 2014; 2015; Ugras et al, 2022; Ulupinar et al, 2021), post-3 minutes (Daskalopoulou et al, 2014), post-5 minutes (Lagzdina et al, 2020; Tsai et al, 2021) to post-10 minutes (Qiu et al, 2018).…”

The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis

“…Irisin improved OA by preventing the activation of the PI3K/Akt/NF-κB cascade response and decreasing the inflammation-induced scorching of chondrocytes, according to the results of biochemical analysis and biochemical indices [ 46 ]. Irisin had a protective effect on cartilage by preventing the Wnt/β-catenin and NF-κB signaling pathways, decreasing the expression of matrix metalloproteinases, improving the stability of the extracellular matrix, reducing inflammatory factors in chondrocytes, inhibiting apoptosis, and encouraging chondrocyte proliferation [ 47 ].…”

“…The preventive mechanism of exercise in cartilage tissues to prevent and manage OA was better elucidated when irisin was discovered, and it was described as a myokine released by skeletal muscle in response to exercise stimulation, implicated in resistance to aging [ 47 , 56 , 57 ]. Therefore, some research investigated the possibility of modulating irisin through physical activity.…”