Effects of Acute Administration of Transdermal Estrogen on Postmenopausal Women With Systemic Hypertension

Mercuro, Giuseppe; Zoncu, Sandra; Pilia, Ilaria; Lao, Adriana; Melis, Gian Benedetto; Cherchi, A

doi:10.1016/s0002-9149(97)00444-x

Cited by 50 publications

(28 citation statements)

References 14 publications

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“…18 Other studies are in keeping with our findings, but did not correct for the level of blood pressure [19][20][21] or reported that withdrawal of hormonal replacement therapy for 4 weeks resulted in a decrease of systemic arterial compliance and an increase in pulse wave velocity in the femoralisdorsalis pedis region, but not in the aorto-femoral territory. 21 Recent studies using ambulatory monitoring [22][23][24][25][26] or automated blood pressure self-measurement 27 are…”

Section: Discussionmentioning

confidence: 99%

“…Initially, the sample had been stratified by sex and age (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59), у60 years), in an attempt to recruit the same number of subjects in each stratum. Households were identified from population registries as persons who shared the same address.…”

Section: Study Populationmentioning

confidence: 99%

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Menopause and the characteristics of the large arteries in a population study

et al. 2001

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In previous cross-sectional and longitudinal population studies, we found that the slope of systolic pressure on age was steeper in postmenopausal than in premenopausal women. We hypothesised that this observation could be due to a specific effect of menopause on the elasticity of the large arteries. We investigated 315 randomly selected women, aged 30 to 70 years. Based on 5.2 years of follow-up, 166 women were premenopausal and 149 menopausal (44 reaching menopause and 105 postmenopausal). These women were matched on age and body mass index with 315 men. We used a walltracking ultrasound system to measure the diameter, compliance and distensibility of the brachial and the common carotid and femoral arteries as well as carotidfemoral pulse wave velocity. Pulse pressure was determined from 24-h blood pressure recordings. Both in menopausal women (r = 0.37; P Ͻ 0.001) and in matching male controls (r = 0.16; P = 0.04), pulse pressure widened with increasing age. The slope of the 24-h pulse pressure on age was steeper in menopausal

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Menopause and the characteristics of the large arteries in a population study

et al. 2001

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“…5,6 In hypertensive women a number of small studies have documented an antihypertensive effect. Transdermal oestradiol can reduce daytime systolic pressure, 7 achieve an absolute reduction in overall pressures 8 and restore a normal 24-h ambulatory blood pressure profile. 9 Other studies have shown no effect of oestrogens on blood pressure in the hypertensive population but a reduction in plasma renin and aldosterone levels.…”

Section: Discussionmentioning

confidence: 99%

“…4 Little information is available regarding the long-term effects of HRT in hypertensive women, but short duration studies in hypertensive women have demonstrated either a neutral or even modest hypotensive effect. [5][6][7][8][9][10] Cyclical HRT preparations are unacceptable to most women suffering from coronary disease or hypertension. Tibolone is a novel steroid compound, which controls menopausal symptoms, 11 inhibits postmenopausal bone loss 12 and augments forearm blood flow.…”

Section: Introductionmentioning

confidence: 99%

A randomised placebo controlled trial of the effects of tibolone on blood pressure and lipids in hypertensive women

et al. 2000

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The effects of hormone replacement therapy in hypertensive women are controversial. This randomised placebo controlled trial assessed the effect of tibolone 2.5 mg on blood pressure and fasting plasma lipids in 29 hypertensive postmenopausal women over 6 months using a 2:1 randomisation to tibolone. The primary clinical end-point was mean office blood pressure. At 6 months systolic blood pressure declined by 5.30 ؎ 2.87% vs 4.94 ؎ 3.37% whilst diastolic blood pressure declined 5.38 ؎ 2.65% vs 0.85 ؎ 3.69% on tibolone and placebo respectively. These differences were not statistically significant. Triglycerides decreased by 33.3 ؎ 6.1% vs 7.6 ؎ 7.9% (P Ͻ 0.01) and

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“…Further, BP is reduced when endogenous E 2 levels are elevated during pregnancy (Siamopoulos et al, 1996). Data on the BP effects of estrogen replacement therapy (ERT) in menopausal women have been inconsistent, with reports of BP neutral (PEPI Trial Writing Group, 1995), BP lowering (Mercuro et al, 1997;Mercuro et al, 1998;Cagnacci et al, 1999;Seely et al, 1999;Butkevich et al, 2000) and BP elevating effects (Anderson et al, 2004;WassertheilSmoller et al, 2000). In the Postmenopausal Estrogen/Progestin interventions (PEPI) trial, which enrolled 875 healthy normotensive early postmenopausal women, assignment to conjugated equine estrogens (CEE), 0.625 mg/d ± a progestin did not impact systolic or diastolic BP when compared with placebo controls (PEPI Trial Writing Group, 1995).…”

Section: Estrogen Receptorsmentioning

confidence: 99%