Effects of acupuncture on patients with fibromyalgia: study protocol of a multicentre randomized controlled trial

Vas, Jorge; Modesto, Manuela; Aguilar, Inmaculada; Santos-Rey, Koldo; Benítez-Parejo, Nicolás; Rivas-Ruiz, Francisco

doi:10.1186/1745-6215-12-59

Cited by 7 publications

(5 citation statements)

References 39 publications

(41 reference statements)

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“…32 In order to evaluate the influence of family structure, a semi-structured interview, incorporating the genogram technique, was performed. 27 …”

Section: Discussionmentioning

confidence: 99%

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Acupuncture for Fibromyalgia in Primary Care: A Randomised Controlled Trial

Vas¹,

Santos-Rey²,

Navarro-Pablo

et al. 2016

Acupunct Med

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Objectives To evaluate the efficacy of an individualised acupuncture protocol for patients with fibromyalgia. Methods Randomised controlled multicentre trial, blinded to participants and to data analysts. Conducted in three primary care centres in southern Spain. A total of 164 participants aged over 17 years and diagnosed with fibromyalgia were enrolled in this trial; 153 participants completed the study. Participants were randomly assigned to either the real intervention (individualised acupuncture, IA) or the sham intervention (sham acupuncture, SA). In both the IA and SA groups, one session per week (lasting 20 min) was provided, in addition to usual pharmacological treatment. The primary outcome was change in pain intensity at 10 weeks. Results Intention-to-treat analysis revealed that the decrease in pain intensity at 10 weeks was greater (p=0.001) in the IA group (−41.0%, 95% CI −47.2% to −34.8%) than in the SA group (−27.1%, 95% CI −33.2% to −20.9%). During the follow-up period, significant differences (p<0.01) in favour of the IA group persisted at 12 months (IA: −19.9%, 95% CI −24.6% to −15.1%; vs SA: −6.2%, 95% CI −11.2% to −1.2%). Conclusions Individualised acupuncture treatment in primary care in patients with fibromyalgia proved efficacious in terms of pain relief, compared with placebo treatment. The effect persisted at 1 year, and its side effects were mild and infrequent. Therefore, the use of individualised acupuncture in patients with fibromyalgia is recommended. Trial Registration Number ISRCTN60217348.

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“…32 In order to evaluate the influence of family structure, a semi-structured interview, incorporating the genogram technique, was performed. 27 …”

Section: Discussionmentioning

confidence: 99%

“…27 The SA group received an acupuncture simulation on the dorsal and lumbar regions, in which guide tubes for the same type of needle as used in the real acupuncture group were applied to the body surface, but after removal of the needles. 27 The time devoted to the treatment and evaluation of participants was identical in both groups.…”

Section: Interventionsmentioning

confidence: 99%

Acupuncture for Fibromyalgia in Primary Care: A Randomised Controlled Trial

Vas¹,

Santos-Rey²,

Navarro-Pablo

et al. 2016

Acupunct Med

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“…We speculate that while inflammation was reduced, it was not eliminated, and thus, inflammatory mediators could continue to activate nociceptors to produce nociceptive behaviors. Clinically, MA is effective in a variety of pain conditions, including neuropathic pain [47], knee osteoarthritis [45,48,49], acute and chronic back pain [49], and fibromyalgia [50]; however, there is a large variability in the acupoints used. Thus, it is possible that a different protocol of MA would be more effective in each of these different models.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models

et al. 2020

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Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory pain models. Methods: TENS 60 Hz, 200 µs, 90% motor threshold (MT), SCS was applied at 60 Hz, an intensity of 90% MT, and a 0.25 ms pulse width. MA was performed by inserting a stainless-steel needle to a depth of about 4-5 mm at the Sanyinjiao (SP6) and Zusanli (ST36) acupoints on a spared nerve injury (SNI), knee joint inflammation (3% carrageenan), and non-inflammatory muscle pain (intramuscular pH 4.0 injections) in rats. Mechanical withdrawal thresholds of the paw, muscle, and/or joint were assessed before and after induction of the pain model, and daily before and after treatment. Results: The reduced withdrawal thresholds were significantly reversed by application of either TENS or SCS (P < 0.05). MA, on the other hand, increased the withdrawal threshold in animals with SNI and joint inflammation, but not chronic muscle pain. Conclusions: TENS and SCS produce similar effects in neuropathic, inflammatory and non-inflammatory muscle pain models while MA is only effective in inflammatory and neuropathic pain models.

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“…Despite wide acceptance among patients and health professionals, evidences on the efficacy of acupuncture in the treatment of FMS are yet lacking. Vas et al [ 30 ] randomized 156 FMS patients to either real or sham acupuncture groups and concluded that it might provide evidence on the efficacy of acupuncture as a therapeutic option for FMS in patients with and without severe depression. Similar to our study design, in another study, Martin et al [ 31 ] randomized 50 fibromyalgia patients to either real or sham acupuncture groups and found that acupuncture significantly resolved fibromyalgia symptoms, compared to placebo, and that the most notable resolution was observed in fatigue and anxiety during follow-up.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Data for Transcutaneous Electrical Nerve Stimulation and Acupuncture Effectiveness in Treatment of Fibromyalgia Syndrome

Yüksel

Ayaş

Cabıoğlu

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Aim. To evaluate the effects of acupuncture and transcutaneous electric nerve stimulation (TENS) applications on the quantitative electroencephalography (qEEG) changes and to evaluate their therapeutic effects in patients with fibromyalgia syndrome (FMS). The study included 42 patients with FMS and 21 healthy volunteers. The patients were randomly assigned to two groups (n=21 in each) to undergo either TENS or acupuncture application. In both acupuncture and TENS groups, baseline electroencephalography (EEG) recording was performed for 10 min and, then, TENS or acupuncture was performed for 20 min, followed by another 10 min EEG recording. Baseline qEEG findings of FMS patients in the TENS and acupuncture groups were similar. Delta and theta powers over the frontal region of FMS patients were lower than controls. Theta powers of right posterior region were also lower than controls. In the TENS group, after the treatment, an increase was observed in the alpha power of the left anterior region as well as a decrease in pain scores. In the acupuncture group, an increase was determined in the alpha power of the right and left posterior regions as well as a decrease in pain score after the treatment. The power of low- and moderate-frequency waves on resting EEG was decreased in the patients with FMS. Decreased pain and increased inhibitor activity were found on qEEG after TENS and acupuncture applications. In conclusion, both TENS and acupuncture applications seem to be beneficial in FMS patients.

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Effects of acupuncture on patients with fibromyalgia: study protocol of a multicentre randomized controlled trial

Cited by 7 publications

References 39 publications

Acupuncture for Fibromyalgia in Primary Care: A Randomised Controlled Trial

Acupuncture for Fibromyalgia in Primary Care: A Randomised Controlled Trial

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models

Quantitative Data for Transcutaneous Electrical Nerve Stimulation and Acupuncture Effectiveness in Treatment of Fibromyalgia Syndrome

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