Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial

Huangfu, Yaru; Peng, Wei; Guo, Baojun; Shen, Zhifu; Li, Li; Liu, Shi-wei; Zheng, Hui; Hu, Youping

doi:10.1016/j.joim.2019.01.007

Cited by 11 publications

(12 citation statements)

References 31 publications

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“…55,56 Furthermore, although the underlying pathophysiological mechanisms are poorly understood, genome-wide association analyses have identified 57 loci associated with insomnia. 57 Several animal experiments have reported that acupuncture treatment for insomnia may be associated with mRNA expression or gene transcription, and clinical studies targeting changes in intestinal microbiome after acupuncture for insomnia have been conducted. 58,59 Therefore, the delayed response of acupuncture treatment observed in our study may have resulted from genetic variations occurring as a cumulative effect of acupuncture treatment.…”

mentioning

confidence: 99%

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

Lee¹,

Kim²,

Jung³

et al. 2020

NSS

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confidence: 99%

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

Lee¹,

Kim²,

Jung³

et al. 2020

NSS

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“…Evidence from clinical trials using the “harmonizing the stomach and mind” principle has confirmed the effectiveness and safety of acupuncture for CID with GI disorder [ 19 , 64 , 65 ]. These acupoints were also presented in a study protocol on the intestinal flora of acupuncture for insomnia and gastrointestinal diseases published by our team [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

The cerebral mechanism of acupuncture for chronic insomnia with gastrointestinal disorder: protocol for a randomized controlled trial

Peng

Xia

Huangfu

et al. 2021

Trials

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Background Many patients with chronic insomnia disorder (CID) have gastrointestinal (GI) symptoms. First-line insomnia medications do not treat GI problems. Acupuncture has a comprehensive regulative action on both CID and GI disorder and is receiving increasing attention. Recent studies indicate that both CID and GI diseases may cause abnormal brain activity. However, the neurological mechanism underlying the effect of acupuncture on such diseases is still unclear. The aim of this study is to explore the pathological mechanisms of CID with GI discomfort, as well as the main response characteristics of acupuncture treatment from multiple perspectives using multimodal magnetic resonance imaging (MRI). Methods A total of 60 participants with CID and GI disorders will be randomly divided into two groups (real acupuncture group and sham acupuncture group; ratio of 1:1). Patients will receive 20 sessions (five sessions per week) of real acupuncture treatment or sham acupuncture treatment. The primary outcome is the aggregate score on the Pittsburgh Sleep Quality Index. Secondary outcomes are scores on the Gastrointestinal Symptom Rating Scale, Self-Rating Anxiety Scale, and Self-Rating Depression Scale. Multimodal MRI scans and clinical assessments will be performed both at baseline and post-treatment. Another 30 age-, sex-, and education-matched healthy subjects will be recruited as controls and will receive MRI scans and clinical evaluations. Discussion This study aims to provide scientific evidence for the mechanism of acupuncture in treating CID with GI disorder using multimodal MRI imaging data on brain structure, function, and metabolism. Trial registration Chinese Clinical Trial Registry, ChiCTR1800017092 (URL: http://www.chictr.org.cn/showproj.aspx?proj=27173). Registered on July 11, 2018.

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“…Insomnia is a common complaint that can be closely bidirectionally related to gastrointestinal symptoms [36]. us, it is ideal to simultaneously improve gastrointestinal Figure 6: Effects of MSZRD on histological evaluation of brain tissue with H&E staining and Nissl staining.…”

Section: Discussionmentioning

confidence: 99%

Soporific Effect of Modified Suanzaoren Decoction and Its Effects on the Expression of CCK‐8 and Orexin‐A

Zhan

Dong

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as a treatment for insomnia for more than a thousand years. However, recent studies have found no significant effects of SZRT as a treatment for insomnia caused by gastric discomfort. Herein, we studied the effects of modified Suanzaoren decoction (MSZRD) on gastrointestinal disorder-related insomnia. The main constituents of MSZRD were spinosin (2.21 mg/g) and 6-feruloylspinosin (0.78 mg/g). A pentobarbital-induced animal model of insomnia showed that MSZRD shortened sleep latency and prolonged sleep time of the male Institute of Cancer Research (ICR) mice treated for 7 days with oral MSZRD. Sprague-Dawley male rats were treated daily with oral MSZRD or placebo for 11 days and then deprived of sleep for the last 4 days to establish a model of insomnia. Of note, MSZRD-treated animals had significantly improved body weight, organ index scores, and fecal moisture relative to placebo-treated animals, as well as reduced temperature. Sleep-deprived rats exhibited more exploratory behaviors in an open-field anxiety test; however, this effect was significantly reduced in MSZRD-treated animals. We found that MSZRD treatment decreased gastric acid pH, decreased the production of gastrin, pepsin, and Orexin-A, and increased the expression of MTL and CCK-8. Importantly, serum GABA concentration was increased by treatment with MSZRD, as reflected by a decreased Glu/GABA ratio. Treated animals had increased the expression of GAD1, GABARA1, and CCKBR but decreased the expression of Orexin R1. In summary, these results suggest that MSZRD has soporific and gastroprotective effects that may be mediated by differential expression of CCK-8 and Orexin-A.

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Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial

Cited by 11 publications

References 31 publications

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

The cerebral mechanism of acupuncture for chronic insomnia with gastrointestinal disorder: protocol for a randomized controlled trial

Soporific Effect of Modified Suanzaoren Decoction and Its Effects on the Expression of CCK‐8 and Orexin‐A

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